Joseph W. Shelton

18 F-Fluciclovine or 68 Ga-PSMA-11 PET/CT–guided Salvage Radiotherapy Changes in Postprostatectomy Biochemical Recurrence: Secondary Analysis of the EMPIRE-2 Trial

Olayinka A. Abiodun-Ojo, Ashesh B. Jani, Subir Goyal, Ismaheel Lawal et autres

Molecular imaging with 18 F-fluciclovine or 68 Ga–prostate-specific membrane antigen–11 had a substantial effect on PET/CT-guided salvage radiotherapy planning in participants with prostate cancer recurrence after prostatectomy.

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Genomic risk classifier performance in PET-guided post-prostatectomy patients: Secondary analysis of a randomized trial.

Vishal Ramesh Dhere, David M. Schuster, Subir Goyal, Eduard Schreibmann et autres

386 Background: Genomic risk assessment with genomic classifiers (GC) have enhanced risk stratification in post-prostatectomy patients, however, validation studies have relied on conventional imaging workup to guide secondary radiation treatment (SRT). Our hypothesis is that GC will remain prognostic in a population …

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Treatment and outcomes of primary urethral cancer treated with radiation therapy

Benjamin D. Hopkins, David C. Qian, Tony Y. Eng, Rebecca C. Marchant et autres

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Patient and fraction specific model adaptation for cone beam computed tomography (CBCT) multi‐organ segmentation

Xiaoqian Chen, Richard L. J. Qiu, Vanessa Lynne Wildman, Ryan James Sanford et autres

Abstract Background Cone‐beam computed tomography (CBCT) has gained considerable traction in medical imaging due to its ability to provide on‐board three‐dimensional (3D) volumetric imaging with relatively low radiation dose, aiding in tracking anatomical changes. However, artifacts such as scatter, noise, and respiratory …

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[18F]-Fluciclovine or [68Ga]-PSMA-11 Molecular Imaging To Guide Dose Escalation of Salvage Radiotherapy After Radical Prostatectomy for Prostate Cancer: The EMPIRE-2 Trial

Ashesh B. Jani, Vishal Ramesh Dhere, Subir Goyal, Eduard Schreibmann et autres

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Risk factors and clinical outcomes of radiation-induced fistula after chemoradiation and image-guided brachytherapy for locally advanced cervical cancer

Naba Ali, Katherine L. Martin, Rachel Tobillo, Karthik Meiyappan et autres

Purpose/Objectives: The standard treatment for locally advanced cervical cancer (LACC) is concurrent chemoradiation and brachytherapy (CRT-B). Fistula formation is a serious complication of pelvic radiation; however, risk factors and outcomes are not well described. We sought to identify the incidence, risk factors …

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Associations among HPV persistence, the vaginal microbiome, and cervical cancer recurrence

Despina Tsementzi, Rebecca Meador, Tony Y. Eng, Joseph W. Shelton et autres

BACKGROUND: In the US, up to 60% of cervical cancer (CxCa) survivors will have persistent HPV infection, the causative agent of CxCa, and up to 35% will develop recurrent local CxCa within 4 years after chemo-radiation therapy. Preliminary studies suggest healthy vaginal …

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Volumetric Changes and Acute Toxicity With 68Ga Prostate-Specific Membrane Antigen Versus 18F-Fluciclovine Positron Emission Tomography/Computer Tomography Guided Postprostatectomy Radiation: Final Analysis of a Randomized Trial

Vishal Ramesh Dhere, David M. Schuster, Subir Goyal, Eduard Schreibmann et autres

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CT-guided CBCT multi-organ segmentation using a multi-channel conditional consistency diffusion model for lung cancer radiotherapy

Xiaoqian Chen, Richard L. J. Qiu, Shaoyan Pan, Joseph W. Shelton et autres

In cone beam computed tomography (CBCT)-guided adaptive radiotherapy, rapid and precise segmentation of organs-at-risk (OARs) is essential for accurate dose verification and online replanning. The quality of CBCT images obtained with current onboard CBCT imagers and clinical imaging protocols, however, is often …

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Advancing the evaluation of radiation‐induced vaginal toxicity using ultrasound radiomics: Phantom validation and pilot clinical study

Jing Wang, Joseph W. Shelton, Boran Zhou, Deborah Catherine Marshall et autres

BACKGROUND: Radiation-induced long-term toxicities, such as vaginal stenosis, severely impact the quality of life for patients undergoing pelvic radiotherapy (RT) for gynecologic (GYN) malignancies. However, current methods for assessing these toxicities rely on subjective physical examinations and patient-reported symptoms, leading to inconsistencies …

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Synthetic CT image generation for CBCT-guided lung radiotherapy using a diffusion model

Xiaoqian Chen, Richard L. J. Qiu, Junbo Peng, Joseph W. Shelton et autres

Despite having lower image quality than planning CTs (pCT), cone beam computed tomography (CBCT) is widely used in the clinic to guide the radiation delivery due to its efficient scanning time. The so-called, image-guided radiation therapy (IGRT) leverages CBCT to minimize patient …

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Automatic multiorgan segmentation in lung CBCT images using a multichannel conditional consistency diffusion model

Xiaoqian Chen, Richard L. J. Qiu, Shaoyan Pan, Joseph W. Shelton et autres

Accurate and timely segmentation of organs-at-risk (OARs) is crucial for efficient and high-quality radiation therapy planning. Fast and precise segmentation of targets and OARs in cone beam computed tomography (CBCT) images can benefit accurate tumor and organ localization during a course of …

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