Stefan Hörer

Disrupting the CTGF–MMP7 Axis in Pulmonary Fibrosis: A Novel High-Affinity Antibody Outperforms Pamrevlumab in Patient-Derived Models

Maria Myzithras, Fidel Ramírez, Ryan Sheehan, Priyanka Gupta et autres

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by aberrant epithelial remodeling and extracellular matrix deposition. Connective tissue growth factor (CTGF), is upregulated in IPF and linked to disease onset and progression. However, the recent failure of pamrevlumab, an …

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Structure of a Therapeutic Full-Length Anti-NPRA IgG4 Antibody: Dissecting Conformational Diversity

Michaela Blech, Stefan Hörer, Alexander B. Kuhn, Sebastian Kube et autres

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Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell–Derived Neurons

Stefanie Traub, Heiko F. Stahl, Holger Rosenbrock, Eric J. Simon et autres

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High-Throughput Crystallography and Its Applications in Drug Discovery

Herbert Nar, Dennis Fiegen, Stefan Hörer, Alexander Pautsch et autres

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Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments

Stefan Hörer, D.J. Reinert, K. Ostmann, Yvette Hoevels et autres

Keap1 is a substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex and plays an important role in the cellular response to oxidative stress. It binds Nrf2 with its Kelch domain and thus triggers the ubiquitinylation and degradation of Nrf2. Oxidative stress …

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Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications

Michaela Blech, Daniel Seeliger, Barbara Kistler, Margit Bauer et autres

Polyclonal autoantibodies against human GM-CSF (granulocyte/macrophage colony-stimulating factor) are a hallmark of PAP (pulmonary alveolar proteinosis) and several other reported autoimmune diseases. MB007 is a high-affinity anti-(human GM-CSF) autoantibody isolated from a patient suffering from PAP which shows only modest neutralization of …

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The Mannitol Operon Repressor MtlR Belongs to a New Class of Transcription Regulators in Bacteria

Kemin Tan, S. Clancy, Maria Borovilos, Min Zhou et autres

Many bacteria express phosphoenolpyruvate-dependent phosphotransferase systems (PTS). The mannitol-specific PTS catalyze the uptake and phosphorylation of d-mannitol. The uptake system comprises several genes encoded in the single operon. The expression of the mannitol operon is regulated by a proposed transcriptional factor, mannitol …

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Structure of a CBS-domain pair from the regulatory γ1 subunit of human AMPK in complex with AMP and ZMP

Philip M. Day, Andrew Sharff, Lina Parra, Anne Cleasby et autres

AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK gamma1 in complex with the …

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Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP

Philip M. Day, Andrew Sharff, Leidy Yurany Cárdenas Parra, Anne Cleasby et autres

CCDC 286584: Experimental Crystal Structure Determination

C. Bruntner, Tobias Binder, Wasu Pathom-Aree ., Michael Goodfellow et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 257637: Experimental Crystal Structure Determination

D. Weber, Eberhard Heller, Christoph Hoenke, Stefan Hörer et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Frigocyclinone, a Novel Angucyclinone Antibiotic Produced by a Streptomyces griseus Strain from Antarctica

Christina Bruntner, Tatiana Binder, Wasu Pathom-Aree ., Michael Goodfellow et autres

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