Accès ouvert
2026
article
OpenAlex
Robin Schürfeld, F Baalmann, Ekaterine Baratashvili, Benjamin Sandner et autres
Introduction Kallikrein-related peptidase 7 (KLK7) is a protease implicated in metabolic disease and obesity. Patients with chronic kidney disease (CKD) exhibit several cardio-metabolic comorbidities and increased mortality. The goal of this study was to investigate the associations of KLK7 levels with renal …
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Accès ouvert
2026
article
OpenAlex
Petra Baum, Joanna Kosacka, Thomas Ebert
BACKGROUND: Polyneuropathy (PN) is a common neurological disorder characterized by sensory, motor, and autonomic dysfunction of peripheral nerves. Its incidence is increasing, especially among the elderly population, making PN a significant and growing public health concern worldwide. MAIN BODY: This review highlights …
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Accès ouvert
2025
article
OpenAlex
Petra Baum, Thomas Ebert, Nora Klöting, Sontje Krupka et autres
Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of …
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2024
article
OpenAlex
Daria Meyer, Joanna Kosacka, Martin von Bergen�, Bruno Christ et autres
Due to the increasing life expectancy and life style, the incidence of primary liver cancer is steadily rising. Worldwide, it is the fourth leading reason of cancer-associated death [29,33]. The etiology of liver cancer is highly diverse including besides others viral, toxic, …
de
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Accès ouvert
2023
article
OpenAlex
Robin Schürfeld, Benjamin Sandner, Annett Hoffmann, Nora Klöting et autres
Objective Acyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has lately been described as an endocrine factor affecting food intake and lipid metabolism. ACBP is dysregulated in catabolic/malnutrition states like sepsis or systemic inflammation. However, regulation of ACBP has not been investigated in conditions with impaired …
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2023
article
OpenAlex
Robin Schürfeld, Benjamin Sandner, Annett Hoffmann, Nora Klöting et autres
Objective Acyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has recently been introduced as an endocrine factor affecting food intake and lipid metabolism. ACBP is dysregulated in catabolic/malnutrition states like sepsis or systemic inflammation. However, regulation of ACBP has not been investigated in human and murine …
de, us
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Accès ouvert
2022
article
OpenAlex
Sandra Nickel, Madlen Christ, Sandra Schmidt, Joanna Kosacka et autres
Mesenchymal stromal cells (MSC) increasingly emerge as an option to ameliorate non-alcoholic steatohepatitis (NASH), a serious disease, which untreated may progress to liver cirrhosis and cancer. Before clinical translation, the mode of action of MSC needs to be established. Here, we established …
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Accès ouvert
2022
article
OpenAlex
Michał Bulc, Katarzyna Palus, Jarosław Całka, Joanna Kosacka et autres
Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter of the central and peripheral nervous systems, predominantly secreted in the gastrointestinal tract, especially in the gut. 5-HT is a crucial enteric signaling molecule and is well known for playing a key role in …
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Accès ouvert
2022
article
OpenAlex
Joanna Kosacka, C Berger, Uta Ceglarek, Anne Hoffmann et autres
The angiotensin-converting enzyme 2 (ACE2) receptor has been identified as the entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is abundantly expressed in many organs. With respect to the role of circulating ACE2 and its receptor expression in …
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Accès ouvert
2021
article
OpenAlex
Petra Baum, Klaus V. Toyka, Matthias Blüher, Joanna Kosacka et autres
The pathogenesis of diabetic neuropathy is complex, and various pathogenic pathways have been proposed. A better understanding of the pathophysiology is warranted for developing novel therapeutic strategies. Here, we summarize recent evidence from experiments using animal models of type 1 and type …
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Accès ouvert
2021
article
OpenAlex
Sabine Paeschke, Karsten Winter, Ingo Bechmann, Nora Klöting et autres
Recent studies have shown an association between iron homeostasis, obesity and diabetes. In this work, we investigated the differences in the metabolic status and inflammation in liver, pancreas and visceral adipose tissue of leptin receptor-deficient db/db mice dependent on high iron concentration …
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Accès ouvert
2021
article
OpenAlex
Petra Baum, Severin Koj, Nora Klöting, Matthias Blüher et autres
Treatment-induced neuropathy in diabetes (TIND) is defined by the occurrence of an acute neuropathy within 8 weeks of an abrupt decrease in glycated hemoglobin-A1c (HbA1c). The underlying pathogenic mechanisms are still incompletely understood with only one mouse model being explored to date. …
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