Manuela Liguori

Age‐Matched Reference Values for Circulating Natural Killer T ( NKT )‐Like Cells

Elena Trombetta, Manuela Liguori, Federico Colombo, Marta Tornese et autres

Natural Killer T-like cells are T lymphocytes characterised by the expression of CD56 accompanied by perforin and granzyme B production, typical of cytotoxic cells and the innate immunity compartment. Imbalance in their distribution could occur in pathological conditions, including solid or haematological …

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Neonatal alloimmune neutropenia: diagnosis and management of 31 Italian patients.

Alessandra Cattaneo, Manuela Liguori, Elena Trombetta, Ferruccio Ceriotti et autres

BACKGROUND: In neonates, antibody-mediated destruction of neutrophils may occur as a consequence of auto- or isoimmune disorders. There are few studies on this topic, and particularly on neonatal alloimmune neutropenia (NAN). MATERIALS AND METHODS: We retrospectively evaluated the clinical and molecular/serological findings …

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Dataset related to article "Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy"

Cristina Belgiovine, Roberta Frapolli, Manuela Liguori, Elisabeth Digifico et autres

This record contains data related to article “Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy". A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages …

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Dataset related to article "Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy"

Cristina Belgiovine, Roberta Frapolli, Manuela Liguori, Elisabeth Digifico et autres

This record contains data related to article “Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy". A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages …

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Inhibition of tumor‐associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti‐PD‐1 therapy

Cristina Belgiovine, Roberta Frapolli, Manuela Liguori, Elisabeth Digifico et autres

A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and, hence, promote tumor immune evasion. Depletion of TAMs or modulation of their …

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Author response for "Inhibition of Tumor‐Associated Macrophages by trabectedin improves the anti‐tumor adaptive immunity in response to anti‐PD‐1 therapy"

Cristina Belgiovine, Roberta Frapolli, Manuela Liguori, Elisabeth Digifico et autres

Dataset related to article "The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33"

Manuela Liguori, Elisabeth Digifico, Alessandro Vacchini, Roberta Avigni et autres

This record contains data related to article “The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33" Abstract In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was …

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Dataset related to article "The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33"

Manuela Liguori, Elisabeth Digifico, Alessandro Vacchini, Roberta Avigni et autres

This record contains data related to article “The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33" Abstract In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was …

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The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33

Manuela Liguori, Elisabeth Digifico, Alessandro Vacchini, Roberta Avigni et autres

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Trabectedin, a Drug Acting on Both Cancer Cells and the Tumor Microenvironment

Paola Allavena, Manuela Liguori, Cristina Belgiovine

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Cells with stemness features are generated from in vitro transformed human fibroblasts

Bartolo Bono, Paola Ostano, Martina Peritore, Ilaria Gregnanin et autres

Cancer stem cells (CSCs) have been involved in the maintenance, progression and relapse of several tumors, but their origin is still elusive. Here, in vitro transformed human fibroblasts (cen3tel cells) and the tumorsphere assay were used to search for and possibly characterize …

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Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models

Cristina Belgiovine, Ezia Bello, Manuela Liguori, Ilaria Craparotta et autres

BACKGROUND: Lurbinectedin is a novel anticancer agent currently undergoing late-stage (Phase II /III) clinical evaluation in platinum-resistant ovarian, BRCA1/2-mutated breast and small-cell lung cancer. Lurbinectedin is structurally related to trabectedin and it inhibits active transcription and the DNA repair machinery in tumour …

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