Bartolo Bono

Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X

Bartolo Bono, Giulia Franco, Valentina Riva, Anna Garbelli et autres

Casein Kinase 1 epsilon (CK1ε) is a member of the serine (Ser)/threonine (Thr) CK1 family, known to have crucial roles in several biological scenarios and, ever more frequently, in pathological contexts, such as cancer. Recently, the human DEAD-box RNA helicase 3 X-linked …

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Cells with stemness features are generated from in vitro transformed human fibroblasts

Bartolo Bono, Paola Ostano, Martina Peritore, Ilaria Gregnanin et autres

Cancer stem cells (CSCs) have been involved in the maintenance, progression and relapse of several tumors, but their origin is still elusive. Here, in vitro transformed human fibroblasts (cen3tel cells) and the tumorsphere assay were used to search for and possibly characterize …

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Molecular signatures linked to stemness and tumorigenesis in tumorspheres from in vitro transformed cells

Bartolo Bono

Immunoglobulin superfamily proteins in human and mouse

Bartolo Bono

Automated gene-prediction procedures have a number of shortcomings, and a method has been developed to address some of these. My approach drew upon the ability of hidden Markov models to detect distantly-matching patterns of IgSF sequences at both transcript and genomic DNA …

Tumor interstitial fluid: misconsidered component of the internal milieu of a solid tumor.

Isabel Freitas, Gianfranco Baronzio, Bartolo Bono, Patrizia Griffini et autres

The tumor interstitial fluid (TIF) is a fluid phase present in the extracellular space of all tumors whose importance in oncology is seldom recognized. In order to stimulate other researchers to give it the due importance, a review of the available data …

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Characterization of the metabolism of perinecrotic cells in solid tumors by enzyme histochemistry.

Isabel Freitas, Bartolo Bono, Vittorio Bertone, Patrizia Griffini et autres

Hypoxic tumor cells resist most therapies and cause tumor regrowth when their environment improves. Identifying the adaptation strategies to hypoxia would help develop better tailored cancer therapies. Ehrlich carcinomas implanted on mice were analyzed histochemically for the following enzyme activities: lactate, succinate …

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Enzyme histochemical studies on tumor blood vessels.

Giuseppe Gerzeli, Í. B. de Freitas, Bartolo Bono, Patrizia Griffini et autres

The oxygenation, the growth rate and the metastatic potential of a solid tumor depend on its vascularization and, in particular, on angiogenesis; a therapeutic approach affecting angiogenesis has been suggested as an alternative to conventional ones. Especially the study of the metabolism …

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