Sandra Franco

TroFuse-011 study design: sacituzumab tirumotecan with or without pembrolizumab for advanced triple-negative breast cancer with PD-L1 CPS <10

Hope S. Rugo, Peter Schmid, Javier Cortés, Toshimi Takano et autres

Patients with advanced TNBC with PD-L1 CPS < 10 are typically treated with chemotherapy and experience poor outcomes. Sacituzumab tirumotecan (sac-TMT; MK-2870/SKB264) is a trophoblast cell-surface antigen 2 (TROP2)–directed antibody-drug conjugate with a unique, bifunctional linker that maximizes payload delivery to tumor …

us, gb, es, fr, jp, de, kr, it, ar, mx, cn, br (code pays fourni par la source)

Impact of intensive care unit monitoring on complications after DIEP flap reconstruction

Víctor Hugo Nieto Estrada, Valeria Rocha Yaruro, Horacio Rodriguez Escallon, Liceth Lorena Patarroyo Villalobos et autres

us, ar (code pays fourni par la source)

Economic benefit of expanding mammography screening for breast cancer in Colombia: A cost modelling analysis

Ana María Osorio, Daniel Samacá-Samacá, Melissa Diaz-Puentes, Ana María Ramos et autres

Objectives: Breast cancer (BC) remains a leading cause of mortality, especially when diagnosed at advanced or metastatic stages. Early detection improves survival and reduces treatment costs. This study estimates the economic implications of expanding mammography screening coverage on breast cancer care in …

co (code pays fourni par la source)

Evidence-Based Consensus on the Diagnosis and Treatment of Advanced HER2-Positive and HER2-Low Breast Cancer in Colombia

Mauricio Lema, Luz F. Sua, Abrahám José Hernández Blanquisett, William Mantilla et autres

Background/Objectives: The management of advanced HER2-positive and HER2-low breast cancer is evolving rapidly. This study aimed to generate national, evidence-based clinical recommendations for Colombia, addressing the lack of standardized local guidance. Methods: A systematic literature search (2020–2024) was conducted. The evidence was …

co, cl (code pays fourni par la source)

Highly Efficient Air Sterilization via Low‐Temperature Interfacial Evaporation in Inductively Heated Superhydrophilic Ferromagnetic Filters

Arnau Fons, Cristina Vaca, Eloi Franco‐Trepat, Aritz Lafuente et autres

Abstract The scientific evidence supporting airborne transmission of pathogens in closed spaces highlights the inefficiency of current air circulation and filtration technologies (e.g., HEPA filters, UV, ozone, ionization) in preventing the spread of airborne pathogens. This underscores the urgent need for new …

es (code pays fourni par la source)

Abstract P2-10-12: Pembrolizumab in Early Triple-negative breast cancer: Real world data in Hispano-American women (PETRHA) - Initial results

Daniela Vazquez‐Juarez, Alejandro Aranda-Gutierrez, Yanin Chavarri-Guerra, Fernando Petracci et autres

Abstract Currently, the standard of care for women with stage II-III triple-negative breast cancer (TNBC) includes neoadjuvant chemotherapy combined with pembrolizumab, followed by adjuvant pembrolizumab. Notably, approximately 10% of the participants in the KEYNOTE-522 trial were Hispanic or Latino, highlighting a gap …

Identification of Clinical and Genomic Features Associated with SARS-CoV-2 Reinfections

F Muñoz-López, Antoni E. Bordoy, Francesc Català‐Moll, Verónica Saludes et autres

Although SARS-CoV-2 reinfections remain a concern for healthcare systems worldwide, the factors driving them are still not fully understood. In this study, we examined data for 3303 individuals who experienced two SARS-CoV-2 infections between March 2020 and May 2022 from both clinical …

es (code pays fourni par la source)

Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes

E. Molina, Joan Josep Bech‐Serra, Eloi Franco‐Trepat, Ignasi Jarne-Sanz et autres

Plitidepsin is an antitumoral compound safe for treating COVID-19 that targets the translation elongation factor eEF1A. Here we detect that plitidepsin decreases de novo cap-dependent translation of SARS-CoV-2 and non-viral RNAs but affects less than 13% of the host proteome, thus preserving …

es, us (code pays fourni par la source)

MMS19 and IFIH1 Host Genetic Variants Associate with SARS-CoV-2 Infection in Elderly Residents of Long-Term Care Facilities

Sandra Franco, Macedonia Trigueros, Dolors Palacín, Josep Maria Bonet et autres

The coronavirus disease 2019 (COVID-19) pandemic has significantly affected older adults. Identifying host COVID-19 susceptibility genes in elderly populations remains a challenge. Here, we aimed to identify host genetic factors influencing the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …

es (code pays fourni par la source)

MMS19 and IFIH1 Host Genetic Variants Associate with SARS-CoV-2 Infection in Elderly Residents of Long-Term Care Facilities

Sandra Franco, Macedonia Trigueros, Dolors Palacín, Josep Maria Bonet-Simó et autres

The Coronavirus disease 2019 (COVID-19) pandemic has significantly affected older adults. Identifying host COVID-19 susceptibility genes in elderly populations remains a challenge. Here, we aimed to identify host genetic factors influencing susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We …

es (code pays fourni par la source)

Selecting postoperative adjuvant systemic therapy for early‐stage breast cancer: An updated assessment and systematic review of leading commercially available gene expression assays

David M. Hyams, Avital Bareket‐Samish, Enrique Bargalló‐Rocha, Sebastian Díaz-Botero et autres

Gene expression assays (GEAs) can guide treatment for early-stage breast cancer. Several large prospective randomized clinical trials, and numerous additional studies, now provide new information for selecting an appropriate GEA. This systematic review builds upon prior reviews, with a focus on five …

us, mx, es, br, pe, ar, uy (code pays fourni par la source)

Effect of a comprehensive cancer care pathway and a navigation cancer program on breast cancer care in a middle-income country.

Marilen Escobar, María Alejandra Bravo, Sergio Cervera, Ana María Osorio et autres

e13536 Background: Breast cancer (BC) is the most common cancer in women globally and in Colombia, with around 16.000 new cases estimated in 2022. Mortality associated with BC has decreased for 2 main reasons: screening that leads to early diagnosis and improved …