Accès ouvert
2024
article
OpenAlex
Wendy C. Brown, José Rodolfo Lopes da Silva, Márcio Caetano, Hudson W. de Carvalho
Neoliberalismo e neoconservadorismo são duas racionalidades políticas distintas nos Estados Unidos contemporâneo. Eles apresentam poucas características em comum e até parecem contraditórios em muitos aspectos. No entanto, eles convergem não somente na atual administração presidencial, mas também em seus efeitos des-democratizantes. Suas …
us
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Accès ouvert
2018
article
OpenAlex
Telmo Graça, Pei-Shin Ku, Marta G. Silva, Joshua E. Turse et autres
Anaplasma marginale is a prototypical highly antigenically variant bacterial pathogen dependent on the sequential generation of major surface protein 2 (Msp2) outer membrane variants to establish persistent infection. Msp2 is encoded by a single expression site, and diversity is achieved by gene …
us
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Accès ouvert
2018
article
OpenAlex
Gina M. Gallego-López, Audrey O.T. Lau, Wendy C. Brown, Wendell C. Johnson et autres
Bovine babesiosis caused by Babesia bovis is a tick-borne hemoparasitic disease of global impact, and improved control is needed. In B. bovis , spherical body protein 2 (SBP -2 ) truncated copies 7, 9 and 11 ( sbp2t7 , sbp2t9 and sbp2t11 …
us
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2017
article
OpenAlex
Cleverson D. Souza, John P. Bannantine, Wendy C. Brown, M. Grant Norton et autres
AIMS: We evaluated the potential of a nanoparticle (NP) delivery system to improve methods of delivery of candidate peptide-based vaccines for Paratuberculosis in cattle. METHODS AND RESULTS: Peptides derived from Mycobacterium avium subsp. paratuberculosis (Map), and the pro-inflammatory monophosphoryl lipid A (MPLA) …
us, Égypte
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Accès ouvert
2016
article
OpenAlex
Bing Zhang, Antonio Cavallaro, Karishma T. Mody, Jun Zhang et autres
Bovine anaplasmosis or cattle-tick fever is a tick-borne haemolytic disease caused by the rickettsial haemoparasite Anaplasma marginale in tropical and subtropical areas of the world. While difficult to express, the proteins VirB9-1 and VirB10 are immunogenic components of the outer membrane type …
au, us
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Accès ouvert
2016
article
OpenAlex
Sudarvili Shanthalingam, Ahmed Tibary, Jonathan E. Beever, Poothapillai Kasinathan et autres
integrins, is not cleaved and hence remains intact on mature CD18 molecules expressed on the surface of ruminant leukocytes. Leukotoxin secreted by Mannheimia (Pasteurella) haemolytica binds to the intact signal peptide and causes cytolysis of ruminant leukocytes, resulting in acute inflammation and …
us
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Accès ouvert
2016
article
OpenAlex
James R. Deringer, Elkin G. Forero-Becerra, Massaro Wilson Ueti, Joshua E. Turse et autres
Within the protective outer membrane (OM) fraction of Anaplasma marginale, several vaccine candidates have emerged, including a family of OM proteins (OMPs) 7 to 9, which share sequence identity with each other and with the single protein OMP7 in the vaccine strain …
us, br, Ghana
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Accès ouvert
2016
article
OpenAlex
Tomohiro Okagawa, Satoru Konnai, James R. Deringer, Massaro Wilson Ueti et autres
The CD4(+) T-cell response is central for the control of Anaplasma marginale infection in cattle. However, the infection induces a functional exhaustion of antigen-specific CD4(+) T cells in cattle immunized with A. marginale outer membrane proteins or purified outer membranes (OMs), which …
jp, us
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Accès ouvert
2016
article
OpenAlex
Liang Zhao, Donna Mahony, Antonino S. Cavallaro, Bing Zhang et autres
Anaplasma marginale is the most prevalent tick-borne livestock pathogen and poses a significant threat to cattle industry. In contrast to currently available live blood-derived vaccines against A. marginale, alternative safer and better-defined subunit vaccines will be of great significance. Two proteins (VirB9-1 …
au, us
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2016
review
OpenAlex
Wendy C. Brown, Anthony F. Barbet
Tick-transmitted gram-negative bacteria in the family Anaplasmataceae in the order Rickettsiales cause persistent infection and morbidity and mortality in ruminants. Whereas Anaplasma marginale infection is restricted to ruminants, Anaplasma phagocytophilum is promiscuous and, in addition to causing disease in sheep and cattle, …
us
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Accès ouvert
2015
article
OpenAlex
Deirdre R. Ducken, Wendy C. Brown, Debra C. Alperin, Kelly A. Brayton et autres
Anaplasma marginale is a tick-borne rickettsial pathogen of cattle with a worldwide distribution. Currently a safe and efficacious vaccine is unavailable. Outer membrane protein (OMP) extracts or a defined surface protein complex reproducibly induce protective immunity. However, there are several knowledge gaps …
us
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Accès ouvert
2015
article
OpenAlex
Wendy C. Brown, Joshua E. Turse, Paulraj K. Lawrence, Wendell C. Johnson et autres
We have shown that in cattle previously immunized with outer membrane proteins, infection with Anaplasma marginale induces a functionally exhausted CD4 T-cell response to the A. marginale immunogen. Furthermore, T-cell responses following infection in nonimmunized cattle had a delayed onset and were …
us
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