Xingyu Chen

Rational Nanomaterial Design for Ferroptosis Modulation: Bidirectional Therapeutic Strategies in Cancer and Beyond

Zhongqiang Zhu, Ling Jiang, Tong Sun, Xingyu Chen et autres

Abstract Ferroptosis, a unique form of regulated, iron-dependent cell death, has emerged as a therapeutic mechanism for a range of diseases, including cancer, neurodegeneration, metabolic disorders, and organ injuries. However, the clinical translation of small-molecule ferroptosis modulators remains limited due to poor …

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Environmentally Responsive Catalytic Microneedles Enable Cascade Fenton Reaction for Antibacterial Therapy and Accelerated Infected Wound Healing

Yongjie Cai, Xianghe Jiang, Yuemin Wang, F. X. Li et autres

ABSTRACT The persistence of bacterial biofilms and resistance limits the efficacy of traditional therapies, slowing tissue regeneration. Here, we report an innovative pH‐responsive catalytic microneedle system (GZIF@Fe MN) designed to combat bacterial infections by disrupting bacterial redox homeostasis through a cascade Fenton …

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Engineered Long-Acting Mild Hyperthermia Microneedle Patches for Personalized Therapy of Infected Diabetic Wounds

Xinmei Zhang, Miao Zhang, F. X. Li, Wenjie Yang et autres

The clinical treatment of chronically infected wounds faces multiple challenges, including antibiotic resistance, imprecise thermal control, and frequent dressing changes that hinder healing. Herein, we developed a multifunctional mild hyperthermic microneedle patch (GPD-NAS@PDA MN) based on the reversible phase-transition characteristics of lower …

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Aconitum septentrionale Koelle extract alleviates cigarette smoke and lipopolysaccharide-induced chronic obstructive pulmonary disease in mice by modulating the MAPK pathway

Fushun Bao, Ning Wang, Qi Guo, Jun Li et autres

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Dual‐Functional Photonic Crystal Hydrogel: Drug Release Monitoring and Immunomodulation for Chronic Infected Wounds

Xinran Kang, Yuemin Wang, Xinyu Zhao, Chen Chen et autres

Chronic bacterial-infected wounds are difficult to treat due to persistent inflammation, biofilm formation, and antibiotic resistance. Conventional therapeutic approaches, such as systemic or topical antibiotics, are limited by the inability to dynamically monitor drug release at the wound site. To address this …

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MXene-based multi-component conductive hydrogel with synergistic crosslinking networks for high-performance wearable sensors

Xinran Kang, Yuemin Wang, Chen Chen, Jiawen Liu et autres

as a dynamic coordination crosslinker further enhances mechanical toughness. This collaborative design makes it possible to construct a new type of conductive hydrogel system with high mechanical strength, excellent stability, and tunable sensing performance. When attached to human skin, the conductive hydrogel …

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Cyanine5.5 Modified Hyaluronic Acid: Accelerate Infected Wound Healing via Photothermal Therapy, Photodynamic Therapy, and Enzyme‐Like Activities

Yongping Lu, Haiyan Wang, Weiqi Kang, Yue Yu et autres

Abstract The presence of bacterial drug resistance and biofilms significantly hinders the healing of bacteria‐infected wounds by reducing the effectiveness of antibiotics and maintaining inflammatory reactions. To address this issue, a multifunctional hydrogel (HXM) that combines photothermal therapy (PTT), photodynamic therapy (PDT), …

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Stage-Responsive Multifunctional Microneedle Patches for Enhanced Biofilm Penetration and Accelerated Healing of Bacterial Infected Skin Wounds

Yuemin Wang, Kai Xu, Xinyu He, Chao Niu et autres

Biofilms, formed by microorganisms and surrounding substances, hinder traditional drug delivery and delay wound healing. Microneedles, with their excellent mechanical properties, minimally invasive nature, and ability to penetrate biofilms for rapid drug delivery, offer a promising solution for biofilm eradication. In this …

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Dark-blood” Imaging in Coronary CT Angiography Using Dual layer Detector Spectral CT: Effect on Image Quality and Vessel Wall Visibility

Xiaodan Li, Xingyu Chen, Wen‐Cheng Chen, Chunhong Hu et autres

INTRODUCTION: To explore the potential of a newly developed subtraction technique in coronary computed tomography angiography (CCTA) for improving image quality and vessel wall visibility without introducing misregistration artifacts. METHODS: Fifty-six patients who underwent CCTA scans using dual-layer detector spectral CT (SDCT) …

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The miR-125 targeting ARFIP2 and the miR-3770 targeting Rrs1_0 are involved in beta-cypermethrin resistance in cockroach

Tong Cai, Yuting Zhang, Xiancui Zhang, Yanan Zang et autres

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Prediction of the Potential Distribution Area for Quercus acutissima Carruth. in China under Climate Change

Nan Li, Yuhao Li, Jingyi Xie, Xingyu Chen et autres

Quercus acutissima Carruth. is a crucial tree species in China’s forest ecosystem, yet climate change poses a threat to its distribution. This study was designed to precisely predict its potential distribution area under varying climate scenarios. We gathered distribution points from multiple …

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Choline Phosphate Surface-Activated 3D-Printed Porous Titanium Scaffold Combined with Stem Cell Exosomes for Enhancing Bone Defects Repair

Xuezhong Cui, Jing Li, Yuemin Wang, Tong Sheng Sun et autres

In recent decades, porous titanium (Ti) bone-engineered scaffolds have emerged as a promising biomaterial for bone defect repair due to their excellent biocompatibility and mechanical properties. However, the limited bioactivity on the surface of the porous scaffold hinders osteogenesis and osseointegration, thereby …

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