2026
conference-abstract
OpenAlex
Harrison B. Chong, Michael Bryan, Maoxuan Lin, Magdy Gohar et autres
Abstract Background: Sinonasal squamous cell carcinoma (SNSCC) is a rare, aggressive malignancy with limited molecular characterization. Emerging evidence implicates human papillomavirus (HPV) in a subset of cases, but the genomic interplay between viral and host factors remains poorly defined. Methods: We performed …
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2025
conference-abstract
OpenAlex
Diane Yang, Stefan Harry, Harrison B. Chong, Edwin Zhang et autres
Abstract Molecular glues have revolutionized the targeting of proteins by disrupting protein complexes, showing immense therapeutic potential. However, the discovery of suitable targets for these agents remains largely serendipitous. Unlike traditional monovalent molecular glues, we have developed a novel class of dual-warhead …
us
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Accès ouvert
2025
article
OpenAlex
Junbing Zhang, Md Yousuf Ali, Harrison B. Chong, Pei-Chieh Tien et autres
us, cn
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Accès ouvert
2024
article
OpenAlex
Mariko Takahashi, Harrison B. Chong, Siwen Zhang, Tzu-yi Yang et autres
us
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Accès ouvert
2023
preprint
OpenAlex
Mariko Takahashi, Harrison B. Chong, Siwen Zhang, Matthew J. Lazarov et autres
Abstract Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed DrugMap , an atlas of …
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Accès ouvert
2023
article
OpenAlex
Tommy Weiss‐Sadan, Maolin Ge, Makiko Hayashi, Magdy Gohar et autres
Accès ouvert
2023
article
OpenAlex
Tommy Weiss‐Sadan, Maolin Ge, Makiko Hayashi, Magdy Gohar et autres
us
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Accès ouvert
2022
preprint
OpenAlex
Tommy Weiss‐Sadan, Maolin Ge, Addriaan de Groot, Alexander Carlin et autres
Abstract Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through mutation of its negative regulator KEAP1. NRF2 has been studied extensively in KEAP1-mutant cancers, however the role of this pathway in cancers with wildtype KEAP1 remains poorly understood. To …
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