Siwen Zhang

Cross-Platform Consistency of FAIMS Compensation Voltage Optimization in Modern Orbitrap Mass Spectrometers

Siwen Zhang, João A. Paulo

Abstract High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) enhances peptide identification in LC-MS proteomics, but whether optimal compensation voltages (CVs) are transferable between mass spectrometry platforms remains unclear. To address this gap, we used the Pierce Peptide Retention Time Calibration (PRTC) mixture …

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More is not always better: higher lymph node yield is not associated with improved survival in stage I–III colorectal cancer

Nina Schraps, Abdullah Al-Mubarak, Siwen Zhang, Gerrit Wolters-Eisfeld et autres

Background: Colorectal cancer (CRC) is among the most prevalent malignancies worldwide and remains the second leading cause of cancer-related death. Curative treatment approaches rely on R0 resection with adequate regional lymphadenectomy. Current international guidelines recommend a lymph node yield (LNY) of at …

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Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis

Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Jingxuan Zhou et autres

Aberrant mucin-type O-glycosylation is a common feature of pancreatic ductal adenocarcinoma (PDAC), yet its functional contribution to pancreatic tumorigenesis remains incompletely defined. In particular, whether defective core 1 O-glycan maturation cooperates with oncogenic KRAS during early pancreatic neoplasia has not been fully …

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Systematic Targeting of Protein Complexes with Molecular COUPLrs

Diane Yang, Stefan Harry, Harrison B. Chong, Neha Khandelwal et autres

Small molecules that modulate protein complexes have transformed cell biology and oncology, yet few chemical starting points exist to probe protein-protein interactions. To expand this space, we developed molecular COUPLrs, elaborated small molecules flanked by two cysteine‑reactive warheads. Using CONNECT, an integrated …

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Effect of a nurse-led dyadic symptom management intervention on postoperative esophageal cancer patients and their family caregivers: A quasi-experimental trial with a qualitative process evaluation

Shuangni Huang, Yuqing Chen, Jiudi Zhong, Juan Yuan et autres

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Single-Cell Multi-Tissue T Cell Clonal Dynamics Reveal Distinct Immune Coercion Landscapes in MSI and MSS Colorectal Cancer

Qianhe Zhan, Siwen Zhang, Bofu Cao, Lanming Chen et autres

The efficacy of immunotherapy in colorectal cancer (CRC) has long been considered to be closely associated with microsatellite instability (MSI) status. Patients with microsatellite stable (MSS) tumors typically exhibit poor responses to PD-1/PD-L1 inhibitors and a poor prognosis, often being categorized as …

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Enhanced Zn2+ transport pathway constructed by heterogeneous metal-ion oriented intercalation with in situ autogenous conducting network

Zhibiao Wang, Yingfang Hu, Siwen Zhang, Haixi Gu et autres

Vanadates possess a crystal structure conducive to Zn 2+ migration, establishing them as promising cathode materials for aqueous zinc-ion batteries (AZIBs). However, the continuous intercalation/deintercalation of Zn 2+ causes repeated expansion and contraction of the vanadate interlayer spacing, potentially leading to structural …

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Effects of synthesis method of CaO-Ni/CeO2 dual-functional materials for integrated CO2 capture and CH4 dry reforming

Haiming Gu, Minyu Yu, Peng Xu, Shanhui Zhao et autres

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Theoretical research on external electric fields (EEFs) enhanced benzene decomposition over NiFe2O4 nanocluster during chemical looping gasification: The ReaxFF MD approach

Siwen Zhang, Shanhui Zhao, Haiming Gu

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Mechanochemically Engineered TeO2@PBA Interfaces with Tunable Electronic Structures for Highly Stable Sodium-Ion Storage

Jiazhuo Li, Bosi Yin, Ying Sun, Chunwei Dong et autres

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Economic Evaluation Method for Energy Storage System in Power Spot Market

Guangmang Gao, Changsheng Su, Yiqian Sun, M. Wu et autres

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ProTCR: a protein language model-driven framework for decoding TCR-antigen recognition toward precision immunotherapies

Minrui Xu, Manman Lu, Peng Liu, Siwen Zhang et autres

The ability of T-cell receptors (TCRs) to recognize neoantigens is fundamental to the initiation and maintenance of adaptive immune responses. In TCR-based immunotherapies, elucidating the recognition patterns of TCRs for peptides and accurately identifying therapeutically relevant TCR-peptide pairs remain critical challenges. Here, …

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