Keiichi Tominaga

Effectiveness and safety of tacrolimus versus infliximab as rescue therapy for intravenous corticosteroid-refractory acute severe ulcerative colitis: a multicenter cohort study

Takahito Katano, Shinji Okabayashi, Hajime Yamazaki, Mao Matsubayashi et autres

BACKGROUND & AIMS: Acute severe ulcerative colitis (ASUC) refractory to intravenous corticosteroids (IVCS) is a major clinical challenge with limited rescue therapy options. Although tacrolimus has been proposed as a potential rescue therapy, its effectiveness and safety compared with infliximab, widely used …

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Prognostic Effect of MES 1 Inflammatory Extent on Remission Maintenance in Ulcerative Colitis

Mimari Kanazawa, Keiichi Tominaga, Takanao Tanaka, Yuka Yamazaki et autres

INTRODUCTION: Ulcerative colitis (UC) is characterized by continuous inflammation extending from the rectum. Even mild inflammation can present prognostic implications when the disease is extensive. Mayo Endoscopic Score (MES) 1 represents increased risk of relapse, hospitalization, and treatment modification, but it is …

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Localized Gastrointestinal Light Chain (AL) Amyloidosis Under Surveillance for Five Years: A Case Report

Shunsuke Kojimahara, Keiichi Tominaga, Akira Yamamiya, Mimari Kanazawa et autres

Amyloidosis, characterized by the deposition of abnormal protein fibrils in organs, is classified as systemic or localized. Amyloid light chain (AL)-type localized amyloidosis is uncommon, particularly when confined to the gastrointestinal tract. Herein, we report a case of localized gastrointestinal AL-type amyloidosis …

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The Capability of a Novel All‐in‐One Sphincterotome With High Rotation and a Freely Bendable Blade for Various Endoscopic Retrograde Cholangiopancreatography‐Related Procedures

Yasuhito Kunogi, Atsushi Irisawa, Akira Yamamiya, Takumi Maki et autres

Objectives: We aimed to evaluate the capability of a novel all-in-one sphincterotome in various procedures related to endoscopic retrograde cholangiopancreatography (ERCP), including procedures in patients with surgically altered anatomy. Methods: A total of 108 patients who underwent ERCP using the novel all-in-one …

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A case of refractory pouchitis leading to cardiopulmonary arrest

Takanao Tanaka, Keiichi Tominaga, Kengo Matsumoto, Yuka Yamazaki et autres

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Effectiveness of Adjunctive Colchicine for Crohn’s Disease with Heterozygous MEFV E148Q Variant

Yuji Fujita, Keiichi Tominaga, Sayumi Saida, Takeshi Sugaya et autres

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Integrin Inhibitors for Ulcerative Colitis Treatment

Takanao Tanaka, Keiichi Tominaga, Shunsuke Kojimahara, Mimari Kanazawa et autres

BACKGROUND: Ulcerative colitis is a diffuse, non-specific inflammatory bowel disease of unknown etiology with recurrent relapse and remission. The mechanisms of immune-mediated inflammation as a pathogenesis of ulcerative colitis have been increasingly elucidated, leading to development of biological agents and low-molecular-weight agents …

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Remaining Life Estimation Technology of AC Mill Motors for Steel Rolling

Fumihiko Hironaka, Kenichiro Takahashi, Yu Itabashi, Yuji Marutani et autres

Alternating Current (AC) mill motors for steel rolling were introduced around 1990.

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Crohn’s disease exacerbated by ghost pills of upadacitinib

Chihiro Yunomura, Shunsuke Kojimahara, Keiichi Tominaga, Kengo Matsumoto et autres

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Week 2 remission with vedolizumab as a predictor of long-term remission in patients with ulcerative colitis: a multicenter, retrospective, observational study

Taku Kobayashi, Tadakazu Hisamatsu, Satoshi Motoya, Toshimitsu Fujii et autres

BACKGROUND/AIMS: Vedolizumab (VDZ), a gut-selective monoclonal antibody for ulcerative colitis (UC) treatment, has no established biomarkers or clinical features that predict long-term remission. Week 2 remission, a potential predictor of long-term remission, could inform maintenance treatment strategy. METHODS: This retrospective, observational chart …

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Post Hoc Analysis of Anxiety and Behavioral Changes in Japanese Patients With Inflammatory Bowel Disease due to the COVID ‐19 Pandemic: Relationship Between Municipal Population at the Place of Residence and Anxiety

Kohei Wagatsuma, Masanori Nojima, Takayuki Matsumoto, Minoru Matsuura et autres

Aims: The Japan COVID-19 Survey and the Questionnaire for Inflammatory Bowel Disease (J-DESIRE) identified multiple factors associated with anxiety regarding the novel coronavirus disease 2019 (COVID-19). However, no regional differences in anxiety were observed. In this post hoc analysis of J-DESIRE, we …

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The duration of prior anti-tumor necrosis factor agents is associated with the effectiveness of vedolizumab in patients with ulcerative colitis: a real-world multicenter retrospective study

Taku Kobayashi, Tadakazu Hisamatsu, Satoshi Motoya, Minoru Matsuura et autres

BACKGROUND/AIMS: Previous literature suggests that the response of patients with ulcerative colitis to vedolizumab may be affected by previous biologic therapy exposure. This real-world study evaluated vedolizumab treatment effectiveness in biologicnon-naïve patients. METHODS: This was a multicenter, retrospective, observational chart review of …

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