Henrik Larsson

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

L. de Hoyos, F. Schlag, S. Jahagirdar, E. Corfield et autres

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression meta-analysis of social behaviour …

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Editorial: Transdiagnostic approaches to child and adolescent mental health—Integrating development, dimensions, and mechanisms

Alessio Bellato, Stephen P. Becker, Catharina A. Hartman, Henrik Larsson et autres

Abstract Co‐occurrence of child and adolescent neurodevelopmental and mental health conditions is the rule rather than the exception, yet translating this insight into shared frameworks and clinical practice remains challenging. In this Editorial, we are pleased to introduce the 26 papers included …

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The association of ADHD and ADHD medication with adherence to pharmacotherapy for type 2 diabetes: a population-based cohort study from seven countries

Yiling Zhou, Honghui Yao, Tian Xie, Malcolm Bjørn Gillies et autres

Background: Attention-deficit/hyperactivity disorder (ADHD) may compromise adherence to pharmacotherapy in adults with type 2 diabetes, but the relationship is unknown. We investigated the association of ADHD and ADHD medication with antidiabetic medication adherence in multinational cohort data. Methods: Using a common analytical …

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Familial Co‐Aggregation of Neurodevelopmental Conditions and Childhood‐Onset Type 1 Diabetes

Shengxin Liu, Gisele Magarotto Machado, Irzam Hardiansyah, Xinyue Gu et autres

AIM: Childhood-onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (NDCs). We examined whether this association extends to relatives and assessed phenotypic, genetic, and environmental correlations between T1D and NDCs. METHODS: Using Swedish registers, we identified 4 066 634 individuals born …

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From prediction to decision: prediction-based decision rules and target trial emulation in ADHD

Miguel Garcia‐Argibay, Stephen V Faraone, Zheng Chang, Samuele Cortese et autres

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Genome-wide meta-analysis of ADHD symptoms in the adult general population reveals distinct genetics of inattention and hyperactivity-impulsivity

Triinu Varvas, Elis Haan, Laura Hegemann, Natàlia Pujol‐Gualdo et autres

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Shared Genetic Factors Between Stress-related Disorders and Cardiovascular Disease

Can Hou, Yu Zeng, Huazhen Yang, Haowen Liu et autres

Understanding whether and how shared genetic factors contribute to the comorbidity between stress-related disorders (SRDs) and cardiovascular disease (CVD) is important for integrated prevention and treatment, but current evidence remains limited. To address this gap, we integrated Swedish national registers (n = …

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Association between parental ADHD and adverse offspring outcomes: Evidence from a nationwide Swedish register-based study

Honghui Yao, Mengping Zhou, Isabell Brikell, Brian M. D’Onofrio et autres

The potential associations between parental ADHD and a broad spectrum of offspring health outcomes remain uncertain. We explored associations between parental ADHD and multiple adverse outcomes in offspring. We used linked Swedish national registers to identify all individuals born in Sweden between …

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Associations of general and specific psychopathology factors by age 35 with dementia after age 50: a Swedish population-based sibling comparison study

Yangjun Liu, Sara Hägg, Isabell Brikell, Zheng Chang et autres

Abstract Multiple psychiatric disorders are associated with later dementia, but it remains unclear whether these associations reflect a shared liability toward all psychiatric conditions (general psychopathology factor) or diagnosis-specific effects (specific psychopathology factors). In this Swedish register-based cohort study, we investigated these …

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Associations between childhood somatic conditions and psychiatric diagnoses in autistic young adults: a retrospective, population-based cohort study in Sweden

Miriam I Martini, Ralf Kuja-Halkola, Agnieszka Butwicka, Ebba Du Rietz et autres

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Psychiatric and neurological predictors of early ADHD medication discontinuation across the lifespan: a multinational study

Isabell Brikell, Aske Astrup, Theresa Wimberley, Masako Araki et autres

BACKGROUND: Early discontinuation of attention-deficit/hyperactivity disorder (ADHD) medication is common and linked to worse outcomes. Identifying clinical predictors could aid personalised treatment yet evidence is inconsistent across ages and countries/regions. OBJECTIVE: Investigate psychiatric and neurological comorbidity as predictors of early ADHD medication …

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Genetic and environmental architecture of violent victimisation across development and sex: A study of 4.5 million Nordic twins and siblings

Amir Sariaslan, Ralf Kuja‐Halkola, Jonas Forsman, Joonas Pitkänen et autres

Violent victimisation affects 1–4% of populations annually and is associated with subsequent offending, repeat victimisation, and premature mortality, yet its aetiology remains poorly understood. We examined genetic and environmental contributions to victimisation risk across development using nationwide data from 5,296,997 individuals born …

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