The association of ADHD and ADHD medication with adherence to pharmacotherapy for type 2 diabetes: a population-based cohort study from seven countries
Rattachement africain : nl, cn, se, au, us, dk, no, hk, gb, mo, is. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Attention-deficit/hyperactivity disorder (ADHD) may compromise adherence to pharmacotherapy in adults with type 2 diabetes, but the relationship is unknown. We investigated the association of ADHD and ADHD medication with antidiabetic medication adherence in multinational cohort data. Methods: Using a common analytical protocol and population-based databases from seven countries, we identified adults initiating non-insulin antidiabetic medication between 2010 and 2020. ADHD was identified by diagnosis or ADHD medication use. We used the proportion of days covered (PDC) to measure antidiabetic medication adherence and defined the primary outcome, poor adherence, as PDC <80% over 1-, 2-, and 5-year follow-up periods. Time-to-first-discontinuation was the secondary outcome. Country-specific estimates were obtained using logistic and Cox regression and pooled using random-effects meta-analyses. Findings: Among 3,643,197 individuals included, 1,871,870 (51.4%) were female and 88,339 (2.4%) had ADHD (76,973 [87.1%] received ADHD medication). Overall, ADHD was not associated with poor adherence to antidiabetic medication (1-, 2-, and 5-year pooled odds ratios [OR]: 1.01 [95% CI 0.90-1.14], 1.03 [0.91-1.17], and 1.12 [0.95-1.31]); country-specific estimates ranged from 0.79 to 1.32, 0.80 to 1.35, and 0.80 to 1.47 at 1, 2, and 5 years, respectively. Among males, ADHD was associated with poorer adherence (1.09 [95% CI 1.00-1.20], 1.12 [1.00-1.24], and 1.23 [1.11-1.37] at 1, 2, and 5 years). Similar results were found for discontinuation. Among individuals with ADHD, ADHD medication use was consistently associated with better adherence over 1-, 2-, and 5-year follow-up periods (e.g., 5-year pooled OR 0.45 [0.30-0.67]); associations were directionally consistent across countries. Interpretation: Among adults with type 2 diabetes, ADHD may not necessarily compromise antidiabetic medication adherence when appropriately managed in routine care. ADHD pharmacological treatment may support adherence among adults with comorbid ADHD and type 2 diabetes, although its causal effect requires further evaluation. Funding: EU Horizon 2020 Research and Innovation Programme.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The association of ADHD and ADHD medication with adherence to pharmacotherapy for type 2 diabetes: a population-based cohort study from seven countries
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University Medical Center Groningen pays non établi dans la noticeÉtablissement de santé
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University of Groningen Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Central South University Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Karolinska Institutet Department of Medical Epidemiology and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Second Xiangya Hospital of Central South University pays non établi dans la noticeÉtablissement de santé
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Guangzhou Experimental Station pays non établi dans la noticeStructure de recherche
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Guangzhou Regenerative Medicine and Health Guangdong Laboratory pays non établi dans la noticeStructure de recherche
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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SUNY Upstate Medical University pays non établi dans la noticeUniversité ou école supérieure
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Aarhus University Department of Biomedicine pays non établi dans la noticeUniversité ou école supérieure
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University of Bergen Department of Global Public Health and Primary Care pays non établi dans la noticeUniversité ou école supérieure
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Norwegian Institute of Public Health Department of Chronic Diseases pays non établi dans la noticeOrganisme public
University Medical Center Groningen, Department of Epidemiology — University of Groningen et Department of Psychiatry — Central South University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.