Accès ouvert
2026
article
OpenAlex
Michael S. Breen, Ran Tao, Andy Yang, Xuran Wang et autres
Eating disorder (ED) and obsessive-compulsive disorder (OCD) exhibit clinical and genetic overlap, yet whether they converge at the molecular level in the human brain is unknown. We perform large-scale transcriptomic profiling of the dorsolateral prefrontal cortex (DLPFC) and caudate in postmortem tissue …
us
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Accès ouvert
2023
article
OpenAlex
Tomoyo Sawada, André R. Barbosa, Bruno Henrique Silva Araújo, Alejandra E. McCord et autres
OBJECTIVE: Schizophrenia is a brain disorder that originates during neurodevelopment and has complex genetic and environmental etiologies. Despite decades of clinical evidence of altered striatal function in affected patients, studies examining its cellular and molecular mechanisms in humans are limited. To explore …
us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Tomoyo Sawada, Amilton de Lima Barbosa, Bruno Henrique Silva Araújo, Alejandra E. McCord et autres
ABSTRACT Schizophrenia (SCZ) is a brain disorder originating during neurodevelopment with complex genetic and environmental etiologies. Despite decades of clinical evidence of altered striatal function in affected patients, its cellular and molecular underpinnings remain unclear. Here, to explore neurodevelopmental alterations in the …
us
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Accès ouvert
2020
article
OpenAlex
Tomoyo Sawada, Kynon JM Benjamin, Anna C. Brandtjen, Ethan Tietze et autres
In this study, we established induced pluripotent stem (iPS) cell lines from postmortem dura-derived fibroblasts of four control individuals with low polygenic risk score for psychiatric disorders including schizophrenia and bipolar disorder. The fibroblasts were reprogrammed into iPS cells using episomal vectors …
us
(code pays fourni par la source)
2016
article
OpenAlex
Rahul A. Bharadwaj, Andrew E. Jaffe, Qiang Chen, Amy Deep‐Soboslay et autres
Posttraumatic stress disorder (PTSD) follows exposure to a traumatic event in susceptible individuals. Recently, genome-wide association studies have identified a number of genetic sequence variants that are associated with the risk of developing PTSD. To follow up on identifying the molecular mechanisms …
us
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Nikolay A. Ivanov, Ran Tao, Joshua G. Chenoweth, Anna C. Brandtjen et autres
Differentiating pluripotent cells from fibroblast progenitors is a potentially transformative tool in personalized medicine. We previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from postmortem tissue. We hypothesized that these differences in culture success were related to epigenetic differences …
us
(code pays fourni par la source)
Accès ouvert
2015
preprint
OpenAlex
Nikolay A. Ivanov, Ran Tao, Joshua G. Chenoweth, Anna C. Brandtjen et autres
Abstract Differentiating pluripotent cells from fibroblast progenitors is a potentially transformative tool in personalized medicine. We previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from postmortem tissue. We hypothesized that these differences in culture success were related to epigenetic …
us
(code pays fourni par la source)