Allister Grant

Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease

Jane I. Grove, Peggy Cho Kiu Lo, Nick R. G. Shrine, Julian Barwell et autres

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, decompensation, and development of hepatocellular carcinoma …

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Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581]

Heather Jane Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay et autres

Backgrounds & aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide …

gb, jp, cn, us, it, ca (code pays fourni par la source)

P040 Identification and functional characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease

Jane I. Grove, Peggy Cho Kiu Lo, Nick R. G. Shrine, Julian Barwell et autres

Background and Aims Non-alcoholic fatty liver disease (NAFLD) is a complex trait that has a global prevalence estimated as 25%. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, decompensation and development of hepatocellular …

gb, in (code pays fourni par la source)

Identification and functional characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease

Jane I. Grove, Peggy Cho Kiu Lo, Nick R. G. Shrine, Julian Barwell et autres

Abstract Background and aims Non-alcoholic fatty liver disease (NAFLD) is a complex trait that has a global prevalence estimated as 25%. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, decompensation and development of …

gb, us, ca, in (code pays fourni par la source)

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Heather Jane Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay et autres

BACKGROUNDS & AIMS: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide …

gb, jp, cn, us, it, ca (code pays fourni par la source)

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Rosanna Asselta, Elvezia Maria Paraboschi, Alessio Gerussi, Heather Jane Cordell et autres

it, gb, jp, cn, ca, us (code pays fourni par la source)

Utilising data held within ePACT2 to monitor and influence antimicrobial prescribing within secondary care outpatient clinics

Ryan Ashley Hamilton, Allister Grant

Background Assurance and intervention is needed around antimicrobial prescribing in secondary care outpatient settings, which has increased by 21% in 5-years. Use of NHS FP10 prescriptions impedes timely monitoring of prescribing. This project aimed to develop an efficient method for monitoring and …

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Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Marco Carbone, Alessandra Nardi, Steve Flack, Guido Carpino et autres

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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Heather Jane Cordell, Younghun Han, George F. Mells, Yafang Li et autres

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in …

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PWE-277 Fracture prevalence and vitamin D status in primary biliary cirrhosis: the Leicestershire experience

Rajesh Krishnamoorthy, Allister Grant, P Sheldon, Toby Delahooke

Introduction Metabolic bone disease is a recognised complication in Primary Biliary Cirrhosis (PBC) and increases the risk of developing fractures. Although osteoporosis is the major contributor, Vitamin D (25- hydroxy- vitamin- D3) deficiency due to fat-soluble vitamin malabsorption is also a contributing …

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Chronic Hepatitis C Treatment Outcomes in Leicester: A 2-year Analysis

Amandip S. Sahota, Rhona Greig, Allister Grant

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IgG 4-Positive Sclerosing Cholangitis Following Autoimmune Pancreatitis With Deranged CA19.9

Seok Ling Ong, Guiseppe Garcea, Florian Puls, Cathy J. Richards et autres

Sclerosing cholangitis is an autoimmune condition characterized by lymphocytic infiltration within the biliary epithelium leading to multifocal stricturing of the biliary tree. Primary sclerosing cholangitis (PSC) is the most common type encountered clinically. However, a similar process may occur in conjunction with …

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