Giorgio Felzani

Behavioral Adaptation Outperforms Clinical and Immune Biomarkers in Predicting Response to Pulmonary Rehabilitation in Older Patients with Advanced COPD

Patrizia Russo, Stefania Proietti, Laura Vitiello, Simona Pace et autres

Patients with advanced COPD respond differently to pulmonary rehabilitation (PR), and respiratory impairment does not explain these differences. Behavioral adaptation may contribute to this variability. Seventy-seven patients with advanced COPD (GOLD III–IV) completed a 3-week PR programme. Response was defined by change …

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Behavioral Adaptation Outperforms Clinical and Immune Biomarkers in Predicting Response to Pulmonary Rehabilitation in Older Patients with Advanced COPD

Patrizia Russo, Stefania Proietti, Laura Vitiello, Simona Pace et autres

Patients with advanced COPD respond differently to pulmonary rehabilitation (PR), and respiratory impairment does not explain these differences. Behavioral adaptation may contribute to this variability. Seventy-seven patients with advanced COPD (GOLD III–IV) completed a 3-week PR programme. Response was defined by change …

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Pain, Function, Gait, and Surface EMG After Anterior Versus Lateral Total Hip Arthroplasty: A Pilot Prospective Study

Raffaele Iorio, Massimiliano Mangone, Federico Corsetti, Mario Vetrano et autres

Background: Total hip arthroplasty (THA) is an effective treatment for advanced hip osteoarthritis, yet the influence of the surgical approach on early biomechanical and neuromuscular recovery remains debated. The direct anterior approach (DAA) is considered muscle-sparing, whereas the lateral approach (LA) involves …

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Effects of Cigarette Smoking on Oxidative Stress, DNA Damage, Immunological Profile, Viral Susceptibility, and Survival in Patients with Chronic Obstructive Pulmonary Disease

Antonio de Iure, Laura Vitiello, Stefania Proietti, Paola Fortugno et autres

Background: Cigarette smoking promotes persistent systemic alterations in COPD, yet the interplay among genetic susceptibility, oxidative stress, immune dysregulation, impaired control of persistent viral replication, and long-term outcomes remains incompletely understood. Methods: We conducted an observational study in 102 patients aged ≥70 …

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A clinical nomogram for predicting biochemical androgen deficiency in men with chronic spinal cord injury

Daniele Tienforti, Giovanni Terrana, Adriano Ciriani, Riccardo Di Geronimo et autres

CONTEXT/OBJECTIVE: Biochemical androgen deficiency is a frequent but often under-recognized complication in men with chronic spinal cord injury (SCI). We aimed to identify routinely available clinical predictors of biochemical androgen deficiency and to develop a simple risk stratification tool suitable for rehabilitation …

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Integrating Focused Shockwave Therapy into Rehabilitation for Groin Pain Syndrome: A Prospective Study in Soccer Players

Gabriele Santilli, Flavia Santoboni, Elisa Checchi, Antonio Franchitto et autres

Background/Objectives: Groin pain syndrome (GPS) is a frequent and heterogeneous condition in athletes, often associated with persistent pain and functional limitation. Both focused extracorporeal shockwave therapy (f-ESWT) and exercise-based rehabilitation have been proposed as conservative treatment options, but evidence for their combined …

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Wearable powered overground exoskeleton reduces dose-dependently the spasticity in individuals with spinal cord injury

Sanaz Pournajaf, Giovanni Morone, Giorgio Felzani, Leonardo Pellicciari et autres

STUDY DESIGN: A multicenter retrospective pre-post cohort study. OBJECTIVE: This study aimed to evaluate the dose-dependent effects of overground exoskeleton-assisted gait training on spasticity and functional independence in individuals with SCI. SETTING: IRCCS San Raffaele Rome, San Raffaele Sulmona, Centro Neurolesi Bonino …

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Clinical and Metabolic Predictors of Response to Focused Extracorporeal Shockwave Therapy in Rotator Cuff Tendinopathy: A Retrospective Cohort Study

Sveva Maria Nusca, Eleonora Latini, Gabriele Santilli, Gioia Beccarini et autres

Background: Rotator cuff tendinopathy is a major cause of shoulder pain and disability. Focused extracorporeal shockwave therapy (ESWT) is an established conservative treatment option; however, the predictive factors influencing the treatment response remain poorly characterized. Objectives: To identify clinical, demographic, and metabolic …

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Integration of Shear-Wave Elastography and Inertial Motion Sensing for Quantitative Monitoring of Tendon Remodeling After Shockwave Therapy in Greater Trochanteric Pain Syndrome

Gabriele Santilli, Antonello Ciccarelli, Francesco Agostini, Andrea Bernetti et autres

Background: Greater trochanteric pain syndrome (GTPS) is associated with structural tendon alterations and functional impairment. Extracorporeal shockwave therapy (ESWT) is a common treatment, but objective monitoring of tendon remodeling and motor recovery remains limited. Objective: This study aimed to integrate shear-wave elastography …

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Multicenter study on predictors of rehabilitation outcome and home discharge in people with non-traumatic spinal cord injuries

Marco Franceschini, Carrie-Louise Thouant, Maurizio Agosti, Francesca Gimigliano et autres

BACKGROUND: Non-traumatic spinal cord injuries (NTSCI) represent an increasing public health concern, particularly in aging populations, yet there is limited literature on rehabilitation outcomes and key predictors of home discharge in this population. AIM: This study evaluates the impact of demographic and …

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Does irisin mediate metabolic effects of androgen deficiency? A cross-sectional study in men with chronic spinal cord injury

Claudia Venditti, Veronica Carnicelli, Valentina Gizzi, Camilla Tonni et autres

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Comparative analysis of upper body kinematics in stroke, Parkinson's disease, and healthy subjects: An observational study using IMU-based targeted box and block test

Elena Sofia Cocco, Sanaz Pournajaf, Paola Romano, Giovanni Morone et autres

BACKGROUND: The Box and Block Test (BBT) is an essential and widely used test in rehabilitation for the assessment of gross unilateral manual dexterity. Although it is a valid, simple, and ecological instrument, it does not provide a quantitative measure of the …

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