Babett Steglich

Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis

Yang Xu, Jan Philipp Weltzsch, Christoph Kilian, Babett Steglich et autres

Processed single cell sequencing data from Xu, Weltzsch, Kilian et al., J Hepat 2026 . This repository contains an anonymized set of Seurat objects of the human single cell sequencing data and spatial transcriptomics, as well as DEG lists. Human single cell …

Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis

Yang Xu, Jan Philipp Weltzsch, Christoph Kilian, Babett Steglich et autres

Processed single cell sequencing data from Xu, Weltzsch, Kilian et al., J Hepat 2026 . This repository contains an anonymized set of Seurat objects of the human single cell sequencing data and spatial transcriptomics, as well as DEG lists. Human single cell …

Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis

Beibei Liu, Marianne R. Spalinger, Annalisa Invernizzi, Eike Gerdes et autres

Tofacitinib, a pan-Janus kinase inhibitor, and the Janus kinase 1-preferential inhibitors Upadacitinib and Filgotinib are approved for the treatment of ulcerative colitis, yet their molecular mechanisms of action remain incompletely understood. Here, using dextran sulfate sodium-induced and T cell transfer colitis models …

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Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis

Beibei Liu, Marianne R Spalinger, Annalisa Invernizzi, Eike Gerdes et autres

Tofacitinib, a pan-Janus kinase inhibitor, and the Janus kinase 1-preferential inhibitors Upadacitinib and Filgotinib are approved for the treatment of ulcerative colitis, yet their molecular mechanisms of action remain incompletely understood. Here, using dextran sulfate sodium-induced and T cell transfer colitis models …

Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis

Yang Xu, Jan Philipp Weltzsch, Christoph Kilian, Babett Steglich et autres

BACKGROUND & AIMS: Patients with autoimmune hepatitis (AIH) experience increased mortality and severe side effects from non-specific immunosuppressive therapy, highlighting an urgent need for targeted treatment approaches. Here, we aimed to delineate the cellular and molecular network underlying AIH within its spatial …

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THU-311-YI Uncovering novel therapeutic targets for autoimmune hepatitis (AIH): detection via omics integration and validation in proof-of- concept clinical trial

Yang Y. Xu, Jan Philipp Weltzsch, Christoph Kilian, Babett Steglich et autres

New treatment targets in autoimmune hepatitis: detection using integrative omics and target validation in a proof of concept phase II clinical trial

Jan Philipp Weltzsch, Yang Y. Xu, Christoph Kilian, Babett Steglich et autres

Standard immunosuppression for autoimmune hepatitis (AIH) is non-specific with corticosteroids as drug of choice for remission induction. An improved understanding of the underlying pathophysiology is needed and could enable a tailored therapeutic approach and avoid side effects associated with standard therapy. We …

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Protective function of sclerosing cholangitis on IBD

Tanja Bedke, Friederike Stumme, Miriam Tomczak, Babett Steglich et autres

Objective There is a strong clinical association between IBD and primary sclerosing cholangitis (PSC), a chronic disease of the liver characterised by biliary inflammation that leads to strictures and fibrosis. Approximately 60%–80% of people with PSC will also develop IBD (PSC-IBD). One …

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A protective effect of inflammatory bowel disease on the severity of sclerosing cholangitis

Friederike Stumme, Niklas Steffens, Babett Steglich, Franziska Lara Mathies et autres

Background: Primary sclerosing cholangitis (PSC) is a chronic liver disease marked by inflammation of the bile ducts and results in the development of strictures and fibrosis. A robust clinical correlation exists between PSC and inflammatory bowel disease (IBD). At present, published data …

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IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction

Ahmad Mustafa Shiri, Tao Zhang, Tanja Bedke, Dimitra E. Zazara et autres

BACKGROUND & AIMS: The liver is one of the organs most commonly affected by metastasis. The presence of liver metastases has been reported to be responsible for an immunosuppressive microenvironment and diminished immunotherapy efficacy. Herein, we aimed to investigate the role of …

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Tr1 Cells Emerge and Suppress Effector Th17 Cells in Glomerulonephritis

Shiwa Soukou-Wargalla, Christoph Kilian, Lis Noelia Velásquez, Andrés Machicote et autres

T regulatory type 1 (Tr1) cells, which are defined by their regulatory function, lack of Foxp3, and high expression of IL-10, CD49b, and LAG-3, are known to be able to suppress Th1 and Th17 in the intestine. Th1 and Th17 cells are …

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Short-term dietary changes can result in mucosal and systemic immune depression

Francesco Siracusa, Nicola Schaltenberg, Yogesh Kumar, Till Robin Lesker et autres

Abstract Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich in fat over plant-based diets, especially for short periods of time, but the health consequences of this short-term consumption of energy-dense nutrients are unclear. Here, we show that short-term …

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