Accès ouvert
2026
article
OpenAlex
Chiara Ragusa, Valentina Oliveri
Cancer continues to be the primary cause of death despite significant progress in medicine, and finding effective therapies remains a challenge. New treatments are needed to minimize the harmful effects on the body and increase the selectivity of drugs. These therapies must …
it
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Accès ouvert
2026
article
OpenAlex
Pascal Tomasella, Giovanni Lucifora, Carlo Carbone, Roberta Ruffino et autres
HYPOTHESIS: Electrostatic interactions at aqueous interfaces play a central role in controlling the organization and stability of charged particle-laden films. In particular, the explicit dependence of interfacial electrostatics on ionic strength and ion valence might enable to both finely modulate the structure …
it, fr
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Accès ouvert
2026
article
OpenAlex
Alessia Distefano, Damiano Calcagno, Giuseppe Grasso, Olivier Monasson et autres
Tolcapone, a clinically approved drug for the treatment of Parkinson's disease as an adjunct therapy, has recently emerged as a potential modulator of amyloid-β aggregation and toxicity, which are hallmark features of Alzheimer's disease and are also involved in ocular neurodegenerative disorders, …
it, fr
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Accès ouvert
2026
article
OpenAlex
Alessia Distefano, Laura Cifalinò, Alessia Sambugaro, Erik Murador et autres
Metal dyshomeostasis and oxidative stress are implicated in the progression of cancer, and neurodegenerative and peripheral aggregation-related disorders. In this study, we investigated primaquine (PQ), a clinically used antimalarial drug, and PQ-lactobionic acid conjugate (LAPQ), a newly synthesized and characterized derivative obtained …
it
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Accès ouvert
2025
article
OpenAlex
Damiano Calcagno, Valentina Oliveri, Maria Cristina Parravano, Nunzio Tuccitto et autres
Analyzing diffusion processes within complex biomolecular mixtures is essential but technically challenging, especially for understanding molecular interactions in physiological environments. Here, we apply the diffusion-based surface plasmon resonance (D-SPR), a recent, label-free methodology that combines accurate SPR-based diffusion measurements with stochastic computational …
it
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Accès ouvert
2025
article
OpenAlex
Pascal Tomasella, Roberta Ruffino, Francesco Laudani, Giovanni Lucifora et autres
HYPOTHESIS: The real time monitoring at the nanoscale of the irreversible adsorption of nanoparticles at liquid surfaces has not been possible so far, given the inherent limitations of the main techniques employed in the dynamic characterization of these systems. However, a deep …
it, fr
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Accès ouvert
2025
article
OpenAlex
Alessia Sambugaro, Riccardo Pó, Martina Lorenzetto, Giuditta Palmerston et autres
for 8NQ in parallel with stronger effects recorded with 8AQ both alone and in combination with copper. Our chemical and biological findings provide valuable insights into the pharmacological profile of the 8AQ-copper system, paving the way to further investigations and offering new …
it
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Accès ouvert
2024
article
OpenAlex
Salvatore Barreca, Ivan Pietro Oliveri, Francesca Lo Presti, Valentina Oliveri et autres
Polycyclic Aromatic Hydrocarbons (PAH) pose a risk to human health because they are highly toxic, carcinogenic, and mutagenic. In the context of water remediation, hybrid biopolymers are green materials that can reduce the pollutants in environmental matrices. This study aims to propose …
it, es
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Accès ouvert
2024
article
OpenAlex
Damiano Calcagno, Maria Luisa Perina, Gabriele Antonio Zingale, Irene Pandino et autres
Insulin is commonly used to treat diabetes and undergoes aggregation at the site of repeated injections in diabetic patients. Moreover, aggregation is also observed during its industrial production and transport and should be avoided to preserve its bioavailability to correctly adjust glucose …
it
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Accès ouvert
2024
article
OpenAlex
Roberta Puglisi, L. Mancuso, Rossella Santonocito, Antonino Gulino et autres
= 5.76 and a detection limit of 0.81 nM. Selectivity towards dopamine was tested over other interfering analytes commonly present in human saliva. Finally, in order to perform a solid point of care test, CNPs were adsorbed on a solid support and …
it, es
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Accès ouvert
2023
article
OpenAlex
Valentina Oliveri
Amyloid diseases have become a global concern due to their increasing prevalence. Transition metals, including copper, can affect the aggregation of the pathological proteins involved in these diseases. Copper ions play vital roles in organisms, but the disruption of their homeostasis can …
it
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Accès ouvert
2023
article
OpenAlex
Gabriele Antonio Zingale, Alessia Distefano, Irene Pandino, Nunzio Tuccitto et autres
The possibility to monitor peptide and protein aggregation is of paramount importance in the so-called conformational diseases, as the understanding of many physiological pathways, as well as pathological processes involved in the development of such diseases, depends very much on the actual …
it
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