İrfan Karahan

Low muscle mass predicts poor response to neoadjuvant chemotherapy in advanced ovarian cancer

Derya Demirtas Esmer, Emre Hafızoğlu, Murat Bardakçı, Erdem Özkan et autres

BACKGROUND: Advanced epithelial ovarian cancer (EOC) is commonly diagnosed at late stages, and despite improvements with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS), prognosis remains poor. Body composition has emerged as an important determinant of treatment outcomes. Low muscle mass …

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The Royal Marsden Hospital Score Independently Predicts Overall Survival in Patients with De Novo Metastatic Renal Cell Carcinoma Treated with First-Line Tyrosine Kinase Inhibitors: A Multicenter Retrospective Analysis

TOLGA DOGAN, Semra Taş, Taliha Güçlü Kantar, İrfan Karahan et autres

Background: Accurate prognostic stratification is essential for clinical decision-making in metastatic renal cell carcinoma (mRCC). Although the International Metastatic RCC Database Consortium (IMDC) model is widely used, its discriminatory capacity may be limited in specific clinical subpopulations. The Royal Marsden Hospital (RMH) …

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Nutritional approach outcomes in palliative care patients with malnutrition

Merve Taş, Hatice Keleş, İrfan Karahan

Aims: In this study, we aimed to investigate the effects of dietary patterns on activity and performance scores, symptom levels, laboratory parameters, anthropometric measurements and mortality in palliative care patients with high malnutrition risk score. Methods: The effects of enteral and parenteral …

The Impact of Sodium on Prognosis in RCC and NSCLC Patients Receiving Second-line Nivolumab Treatment

İsmet Seven, Seli̇n Aktürk Esen, İrfan Karahan, Efnan Algın et autres

Objective: This study aimed to explore whether serum sodium concentrations could serve as a prognostic marker in patients with metastatic renal cell carcinoma (mRCC) and metastatic non-small cell lung cancer (mNSCLC) who were treated with nivolumab in the second-line setting. Material and …

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When location meets biology: combined risk patterns drive outcomes in primary central nervous system lymphoma

Emre Hafızoğlu, Serhat Sekmek, Doğan Bayram, İrfan Karahan et autres

Aim: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal lymphoma. Despite therapeutic advances, data from immunocompetent patients in real-world cohorts remain limited, and prognostic factors are still not clearly defined- especially in small retrospective series. Material and Methods: …

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Anorectal Malignant Melanoma: Diagnostic Pitfalls and Prognostic Insights from a Single-Center Retrospective Analysis

Emre Hafızoğlu, Murat Bardakçı, Yakup Ergün, İrfan Karahan et autres

Background and Objectives: Anorectal malignant melanoma (ARMM) is a rare and aggressive mucosal melanoma with a poor prognosis. Due to its rarity and nonspecific clinical presentation, diagnosis is often delayed, and prognostic data remain limited. Methods: In this retrospective study, 17 patients …

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Association of Microsatellite Instability with Pro-inflammatory Markers and Survival in Patients with Endometrial Cancer

Serhat Sekmek, İrfan Karahan, Doğan Bayram, Muhammed Bülent Akıncı et autres

Objective: Endometrial cancer is the most common gynaecological cancer and the fourth most common malignancy after breast, lung and colorectal cancer in developed countries.The aim of this study was to investigate the relationship between microsatellite status and simple pro-inflammatory markers and their …

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The predictive value of sarcopenia and PET imaging metrics in metastatic non-squamous NSCLC

İsmet Seven, Mehmet Karacan, İrfan Karahan, Kahraman Kapanşahin et autres

AIM: Metastatic non-small cell lung cancer (NSCLC) patients face a poor prognosis, with a 5-year overall survival (OS) rate of under 10%. In this investigation, we examined the prognostic implications of sarcopenia and metabolic metrics obtained from 18F-FDG PET/CT imaging in individuals …

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Prognostic Significance of ARID1A, PTEN and PD-L1 Expressions and MMR Status in Colorectal Cancer Tissue

Seda Kahraman, Ayça Dilşad KURATMER, İrfan Karahan, Didem Sener Dede et autres

Objective: Studies on the clinical significance and frequency of adenine-thymine-rich interactive domaincontaining protein 1A (ARID1A) mutation or protein expression and the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein expression in colorectal cancer (CRC) are conflicting.In this study, we investigated …

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Clinicopathological features of patients with human epidermal growth factor receptor 2 (HER2) immunohistochemistry 2+ early-stage breast cancer

İrfan Karahan

Clinicopathological features of the patients with human epidermal growth factor receptor immunohistochemistry 2+ early stage breast cancer

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Prognostic Factors and Long-Term Survival in Kaposi’s Sarcoma Patients: Results from a 28-Year Retrospective Cohort

Emre Hafızoğlu, Murat Bardakçı, Yakup Ergün, İrfan Karahan et autres

Background and Objectives: Kaposi’s sarcoma (KS) is a rare malignancy with limited prospective data. The aim of this study was to evaluate the clinical features and prognostic factors of KS in a cohort of patients treated at a single center. Materials and …

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The Effect of Positron Emission Tomography-Computed Tomography Parameters on Pathological Response in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Receiving Neoadjuvant Treatment

Serhat Sekmek, Özkan Bayrakcı, Mehmet Karacan, İrfan Karahan et autres

INTRODUCTION: We aimed to evaluate the relationship between positron emission tomography (PET)/computed tomography (CT) parameters with pathological complete response (pCR) in patients with HER-2-positive breast cancer who received neoadjuvant treatment (NACT). METHODS: This retrospective study included 97 patients. The primary endpoint was …

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