Anorectal Malignant Melanoma: Diagnostic Pitfalls and Prognostic Insights from a Single-Center Retrospective Analysis
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Le résumé fourni par la source
Background and Objectives: Anorectal malignant melanoma (ARMM) is a rare and aggressive mucosal melanoma with a poor prognosis. Due to its rarity and nonspecific clinical presentation, diagnosis is often delayed, and prognostic data remain limited. Methods: In this retrospective study, 17 patients diagnosed with ARMM were identified from a cohort of 404 malignant melanoma cases treated at our center; however, only 14 patients with complete clinical and pathological data were included in the final analysis. Demographic, clinical, and histopathological data were collected. Disease stage, treatment modalities, and survival outcomes were analyzed. Event-free survival (EFS) and overall survival (OS) were calculated, and potential prognostic factors were evaluated using univariate and multivariate analyses. Results: The mean age at diagnosis was 58 ± 12 years, and six patients (42.9%) were female. The median follow-up duration was 13.3 months, and the median OS was 12.6 months. Six patients (42.9%) were initially misdiagnosed due to overlapping symptoms with benign anorectal conditions. At presentation, seven patients had localized disease, while six had distant metastases. Univariate analysis identified male sex and liver metastasis as adverse prognostic factors for OS; however, these associations were not statistically significant in multivariate analysis. Conclusions: ARMM is associated with poor survival outcomes, and liver metastasis and male sex may be linked to worse prognosis. Diagnostic delay is common due to nonspecific symptoms and frequent initial misdiagnosis, highlighting the need for increased clinical awareness. Further large-scale studies are warranted to better define prognostic markers and optimize management strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Anorectal Malignant Melanoma: Diagnostic Pitfalls and Prognostic Insights from a Single-Center Retrospective Analysis
- Date Crossref
- 20/08/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
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Memorial Ankara Hospital pays non établi dans la noticeÉtablissement de santé
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Ankara Bilkent City Hospital Department of Medical Oncology pays non établi dans la noticeÉtablissement de santé
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Afyonkarahisar State Hospital Department of Medical Oncology pays non établi dans la noticeÉtablissement de santé
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Gazi Yasargil Training and Research Hospital Department of Medical Oncology pays non établi dans la noticeÉtablissement de santé
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Bower Hospital Department of Medical Oncology pays non établi dans la noticeÉtablissement de santé
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Gülhane Training and Research Hospital Department of Medical Oncology pays non établi dans la noticeÉtablissement de santé
Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Memorial Ankara Hospital et Department of Medical Oncology — Ankara Bilkent City Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.