Cristina Vaschieri

CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways

Marika Quadri, Luca Reggiani Bonetti, Cristina Pellegrini, Mirco Mastrangelo et autres

The involvement of the neurotrophin network in pathological skin conditions, such as psoriasis or squamous cancer, by their common neurotrophin receptor CD271 has become recently evident. Depending on the specific ligand and co-receptor interacting with it, CD271 mediates various cellular responses in …

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Standardized indirect immunofluorescence-based detection of dermal-binding autoantibodies in pemphigoid diseases: a prospective international multicentre study

Sabrina Patzelt, Rengin Melis Engin, Kossara Drenovska, Charlotte Kiehne et autres

We evaluated a Biochip™-based immunofluorescence assay for improved diagnosis of dermal-binding pemphigoid diseases by detecting autoantibodies against laminin β4, type VII collagen and laminin 332. Results showed high sensitivity, with anti-p200 pemphigoid (laminin β4 reactivity) being more frequent than epidermolysis bullosa acquisita, …

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Anti–TNF-α induced mucous membrane pemphigoid-like disease

Giacomo Setti, Cristina Vaschieri, Stefania Caramaschi, Cristina Magnoni et autres

Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease affecting various mucous membranes, with rare skin involvement. We present a case of a 40-year-old woman with recurring desquamative gingivitis, implicating etanercept, an anti-TNF-α agent, in MMP-like lesions confined to the oral mucosa. …

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ESDR186 - Dissecting the role of the common neurotrophin receptor CD271 in the skin: generation and characterization of a novel mouse model with keratinocyte-specific conditional deletion

Marika Quadri, Elisabetta Palazzo, Luca Reggiani Bonetti, Cristina Vaschieri et autres

Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review

Stefania Guida, Sabrina Longhitano, Marco Ardigò, Riccardo Pampena et autres

BACKGROUND/OBJECTIVES: Non-invasive skin imaging features of main skin inflammatory and autoimmune diseases have been reported, although a comprehensive review of their correlation with histopathologic features is currently lacking. Therefore, the aim of this paper was to review the correlation of dermoscopic, reflectance …

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Case of a severe vulgaris and foliaceus pemphigus in a young patient treated with rituximab, with subsequent development of chronic urticaria

Miriam Rovesti, Elena Pierobon, Cristina Vaschieri, Giovanni Genovese et autres

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Adipose-derived stem cells in wound healing: comparison with fibroblasts and keratinocytes interaction.

Luisa Benassi, Elisabetta Tarentini, Elena Rossi, Alessia Paganelli et autres

Adipose-derived stem cells (ADSCs) are a particular subset of mesenchymal stem cells present in the stromal-vascular fraction of the adipose tissue. These cells are considered very attractive for their relative abundance and accessibility in the human body. Keratinocytes and fibroblasts cells play …

648 Adipose-derived stem cells in wound healing: comparison with fibroblasts and keratinocytes interaction

Luisa Benassi, Elisabetta Tarentini, Elena Rossi, Alessia Paganelli et autres

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A comparative dermoscopic and reflectance confocal microscopy study of naevi and melanoma with negative pigment network

Francesca Farnetani, Alon Scope, Laura Mazzoni, Victor Desmond Mandel et autres

BACKGROUND: Negative pigment network (NPN) is a dermoscopic structure observed more frequently among melanomas than naevi. Precise tissue correlates of NPN are still elusive. OBJECTIVE: To describe the reflectance confocal microscopy (RCM) findings underlying NPN in melanocytic neoplasms. METHODS: We retrospectively identified …

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Effects of topical methotrexate loaded gold nanoparticle in cutaneous inflammatory mouse model

Ilaria Fratoddi, Luisa Benassi, Elisabetta Botti, Cristina Vaschieri et autres

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In vitro Engineering of a Skin Substitute Based on Adipose-Derived Stem Cells

Alessia Paganelli, Luisa Benassi, Irena Pastar, Massimo Pellegrini et autres

In the field of wound healing, stem cell-based strategies are gaining importance for their regenerative potential. Adipose-derived stem cells (ADSCs) are a particular subset of mesenchymal stem cells present in the stromal-vascular fraction of the adipose tissue, today considered very attractive for …

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Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer

Claudia Sorbi, Pasquale Linciano, Annalisa Tait, Claudio Giacinto Atene et autres