Guozhong Li

Gut microbiota and hepatocellular carcinoma: A comprehensive retrospective analysis of clinical evidence

Xiaojuan Yang, Guozhong Li, Yan Qu, Wenjie Zhang

cn (code pays fourni par la source)

RETRACTED: The effect of vitamin C on the JAK/STAT3 pathway in ischemic stroke: based on the molecular interaction between FOXP3 protein and stat3 protein

Wan Wei, Xuehui Fan, Di Zhong, Guozhong Li

cn (code pays fourni par la source)

KCTD10 p.C124W variant contributes to schizophrenia by attenuating LLPS-mediated synapse formation

Chenjun Mu, Pan Liu, Liang Liu, Yaqing Wang et autres

KCTD10, a member of the potassium channel tetramerization domain (KCTD) family, is implicated in neuropsychiatric disorders and functions as a substrate recognition component within the RING-type ubiquitin ligase complex. A rare de novo variant of KCTD10, p.C124W, was identified in schizophrenia cases, …

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Abstract 052: Natural History and Treatment Efficacy of Arteriovenous Shunts Below Conus: An Observational Study

Ying Fan, Peng Yang, Ping Hu, Ming Ye et autres

Spinal arteriovenous shunts below the conus medullaris (AVS‐BC) exhibit a virtually unstudied natural course. This study aimed to clarify the clinical onset, progression, and treatment outcomes of AVS‐BC to optimize comprehensive management strategies.

cn (code pays fourni par la source)

P4.11E.03 Safety and Efficacy of AL2846 Combined with TQB2450 In NSCLC Patients with Previous PD-(L)1 Inhibitor Treated (NCT06116240)

Dandan Huang, Zimin Song, Jie Qin, Dingyong Zhong et autres

cn (code pays fourni par la source)

Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway

Xu Chen, Fangchao Jiang, Yuanfu Mao, Wan Wei et autres

No single treatment significantly reduces the mortality rate and improves neurological outcomes after intracerebral haemorrhage (ICH). New evidence suggests that pyroptosis-specific proteins are highly expressed in the perihaematomal tissues of patients with ICH and that the disulfiram (DSF) inhibits pyroptosis. An ICH …

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A2 reactive astrocyte‐derived exosomes alleviate cerebral ischemia–reperfusion injury by delivering miR ‐628

Ying-Ju Wang, He‐Ping Li, Hanwen Sun, Xu Chen et autres

Ischemia and hypoxia activate astrocytes into reactive types A1 and A2, which play roles in damage and protection, respectively. However, the function and mechanism of A1 and A2 astrocyte exosomes are unknown. After astrocyte exosomes were injected into the lateral ventricle, infarct …

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FOXM1 c.1205 C > A mutation is associated with unilateral Moyamoya disease and inhibits angiogenesis in human brain endothelial cells

Sen Suo, Cheng Fang, Wenting Liu, Qingan Liu et autres

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Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury

Shuai Yang, Xudong Li, Jinhong Yan, Fangchao Jiang et autres

In the current study, we aimed to investigate whether disulfiram (DSF) exerts a neuroprotective role in cerebral ischemiareperfusion (CI-RI) injury by modulating ferredoxin 1 (FDX1) to regulate copper ion (Cu) levels and inhibiting inflammatory responses. To simulate CI-RI, a transient middle cerebral …

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Analysis of the value of NLR, MLR and PLR levels in peripheral blood of patients with RRMS

Jiayun Ren, Weihua Zhang, Lamei Xue, Hongping Chen et autres

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Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia

Ying Gao, Lingling Jiang, Yuesong Pan, Weiqi Chen et autres

Importance: Comparisons are limited for immediate-intensive and delayed-intensive statin for secondary stroke prevention and neuroprotection in patients with acute mild ischemic stroke or transient ischemic attack (TIA) from atherosclerosis. Objective: To estimate whether immediate-intensive statin therapy is safe and can lower the …

cn, us, fr, ca, gb (code pays fourni par la source)

MyD88 Inhibition Attenuates Cerebral Ischemia-reperfusion Injury by Regulating the Inflammatory Response and Reducing Blood–brain Barrier Damage

Fangchao Jiang, Xu Chen, Xuehui Fan, Shuai Yang et autres

cn (code pays fourni par la source)