Accès ouvert
2026
article
OpenAlex
Maria Castronuovo, Guido Capasso, Allison Beltrame, Nayla Mouawad et autres
BACKGROUND: In chronic lymphocytic leukemia (CLL), B-cell receptor, chemokine receptor and integrin signaling contribute to disease progression by influencing cell survival, migration and microenvironment interactions. Focal adhesion kinase (FAK) has recently been involved in these disease processes. Our recent research revealed a …
it
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Accès ouvert
2026
article
OpenAlex
Maria Castronuovo, Guido Capasso, Allison Beltrame, Nayla Mouawad et autres
Additional file 1: Supplementary Methods, Figures S1-S6, and Tables S1-S2.
it
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Accès ouvert
2026
article
OpenAlex
Maria Castronuovo, Guido Capasso, Allison Beltrame, Nayla Mouawad et autres
Additional file 1: Supplementary Methods, Figures S1-S6, and Tables S1-S2.
it
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Accès ouvert
2026
review
OpenAlex
Francesco Angotzi, Arianna Bevilacqua, Andrea Serafin, Nicolò Danesin et autres
The immunoglobulin heavy chain variable region (IGHV) mutational status is a major prognostic factor in chronic lymphocytic leukemia (CLL). While patients are conventionally classified as mutated (M-IGHV) or unmutated (U-IGHV) using a 98% germline identity cutoff, increasing interest has focused on patients …
it
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Accès ouvert
2025
article
OpenAlex
Andrea Visentin, Enrico Gaffo, Moritz Fürstenau, Kerry A. Rogers et autres
In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with …
it, de, us, se, cn, cz, gb, fr, gr, es, nl, ru
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Accès ouvert
2025
article
OpenAlex
Giovanni Ribaudo, Mario A. Pagano, Margrate Anyanwu, Matteo Giannangeli et autres
Cancer represents a leading cause of mortality globally, with its complex biological nature posing significant challenges for treatment. Central to cancer progression are molecular pathways that govern cellular function, among which protein phosphatase 2A (PP2A) plays a vital role. As a serine/threonine …
it
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Accès ouvert
2025
article
OpenAlex
Francesco Angotzi, Alessandro Cellini, Nicolò Danesin, Simone Zoletto et autres
Leukaemic cells from hairy cell leukaemia (HCL) secrete a soluble form of the interleukin-2 receptor (sIL-2R) which is measurable in serum. Previous evidence suggested that sIL-2R may correlate well with tumour burden and demonstrated a reduction in sIL-2R levels after therapy with …
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Accès ouvert
2025
article
OpenAlex
Eleonora Roncaglia, Enrico Gaffo, Giulia Calabretto, Moritz Fürstenau et autres
In Chronic Lymphocytic Leukemia (CLL), t(14;19)(q32;q13), leading to the overexpression of BCL3, is found in ∼1% of cases and is associated with an aggressive disease. In this study, leveraging a large CLL patient cohort collected thanks to an international collaboration, we investigate …
it, de, us, se, cn, cz, gb, fr, gr, es, nl, ru
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Accès ouvert
2024
article
OpenAlex
Guido Capasso, Nayla Mouawad, Maria Castronuovo, Edoardo Ruggeri et autres
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase mainly found in the focal adhesion regions of the plasma membrane and it has a crucial role in migration and the remodeling of cellular morphology. FAK is also linked to several aspects of …
it
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Accès ouvert
2024
article
OpenAlex
Edoardo Ruggeri, Federica Frezzato, Nayla Mouawad, Marco Pizzi et autres
Introduction: In classical Hodgkin lymphoma (cHL), the survival of neoplastic cells is mediated by the activation of NF-κB, JAK/STAT and PI3K/Akt signaling pathways. CK2 is a highly conserved serine/threonine kinase, consisting of two catalytic (α) and two regulatory (β) subunits, which is …
it
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Accès ouvert
2024
article
OpenAlex
Andrea Serafin, Alessandro Cellini, Chiara Adele Cavarretta, Valeria Ruocco et autres
Although the unfavourable prognostic role of complex karyotype (CK) in chronic lymphocytic leukaemia (CLL) patients treated with chemoimmunotherapy has been clarified, its impact on the outcome of patients being treated with novel targeted agents, and especially with venetoclax-based regimens, remains to be …
it
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Accès ouvert
2024
article
OpenAlex
Francesco Angotzi, Alessandro Cellini, Valeria Ruocco, Chiara Adele Cavarretta et autres
Chronic lymphocytic leukemia (CLL) exhibits substantial variability in disease course. The mutational status of the B-cell receptor immunoglobulin heavy variable (IGHV) chain is a critical prognostic factor, categorizing patients into mutated (M-IGHV) and unmutated (U-IGHV) groups. Recently, a third subgroup with borderline …
it
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