Ilya V. Turchin

Quantifying the sensitivity limit of ICG imaging in the presence of tissue autofluorescence

Yuriy Belozerov, Jorge Ripoll, Ilya V. Turchin

Significance: Fluorescent imaging (FI) using indocyanine green (ICG) is a powerful tool in medical diagnostics and surgery. Although numerous studies have focused on optimizing injection protocols and suppressing excitation light leakage, tissue autofluorescence has not been widely recognized as a fundamental factor …

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Assessing axitinib-induced differential responses in tumor vascularization and oxygenation with combined optoacoustic angiography and diffuse optical spectroscopy

Anna Orlova, Ksenia Akhmedzhanova, Anna Glyavina, Alexey A. Kurnikov et autres

Bis‐Diimine Rhenium(I) Complexes for Biomedical Photoacoustic Tomography

Svetlana G. Madieva, Kristina S. Kisel, Julia R. Shakirova, Elizaveta V. Durova et autres

A series of bis‐diimine rhenium(I) complexes Re(NN1‐OMe) − Re(NN3‐OMe) , containing neocuproine and methyl [2‐(pyridin‐2‐yl)quinoline‐4‐carboxylate (NN1), methyl [2,2′‐biquinoline]‐4‐carboxylate (NN2), dimethyl [2,2′‐biquinoline]−4,4′‐dicarboxylate (NN3) was synthesized and characterized. Utilization of the asymmetric NN1 and NN2 ligands affords two types of structural isomers, which were …

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Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography

Pavel Subochev, Xosé Luís Deán‐Ben, Zhenyue Chen, Maxim Prudnikov et autres

Abstract Owing to its unique ability to capture volumetric tomographic information with a single light flash, optoacoustic (OA) tomography has recently demonstrated ultrafast imaging speeds ultimately limited by the ultrasound time-of-flight. The method’s scalability and the achievable spatial resolution are yet limited …

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Optoacoustic Microscopy for in Vivo Assessment of Tumor Vascular Bed and Its Response to Antiangiogenic Therapy

Anna Glyavina, Ksenia Akhmedzhanova, Alexey A. Kurnikov, Yulia Khochenkova et autres

This article presents the findings of an experimental study investigating the development of the Colo 320 xenograft vasculature during both natural tumor growth and under antiangiogenic therapy (Axitinib and Alofanib), utilizing optoacoustic microscopy. The study revealed differences in vessel structure at various …

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Study of Minor Chromophores in Biological Tissues by Diffuse Optical Spectroscopy (Review)

Kseniya Bylinskaya, Valeriya Perekatova, Ilya V. Turchin

oxidase. Identifying minor chromophores using DOS is challenging due to their relatively low absorption contributions compared to major chromophores, as well as the limited understanding of their specific absorption spectra. Nevertheless, the simultaneous detection of both major and minor chromophores could provide …

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Comparative analysis of accuracy of analytical models and Monte-Carlo-based empirical approximation for diffuse reflectance spectroscopy

Valeriya Perekatova, Ekaterina A. Sergeeva, Mikhail Kirillin, Aleksandr V. Khilov et autres

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Effects of FOLFOX Chemotherapy on Tumor Oxygenation and Perfused Vasculature: An In Vivo Study by Optical Techniques

Irina Druzhkova, Kseniya Bylinskaya, Anton A. Plekhanov, Alexey B. Kostyuk et autres

The effects of cytotoxic chemotherapy on tumor vasculature and oxygenation are in the focus of modern investigations because vascular structure and distribution of oxygen influence tumor behavior and treatment response. The aim of our study was to monitor changes in the vascular …

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Wide-band diffuse reflectance spectroscopy with a self-calibrating fiber-optic probe

Ilya V. Turchin, Valeriya Perekatova, Alexey B. Kostyuk, Anna Orlova et autres

We report on creation of a diffuse optical spectroscopy (DOS) setup in a wide VIS-NIR spectral range with a contact fiber-optic probe using a self-calibration technique. A four measurement procedure employing two source and two collection fibers arranged symmetrically allows to calculate …

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Advanced Monte Carlo simulations in spectral and fluorescence optical diagnostics

Mikhail Kirillin, Daria A. Kurakina, Alexandra Getmanskaya, Aleksandr V. Khilov et autres

We report on the development of Monte Carlo based models of signal formation in systems of spectral and fluorescence imaging. Numerical simulations allow tracking photon trajectories providing imaging volume analysis, while parallel processor architecture allows to significantly speed up calculations.

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A refined analytical model for reconstruction problems in diffuse reflectance spectroscopy

Ekaterina A. Sergeeva, Daria A. Kurakina, Ilya V. Turchin, Mikhail Kirillin

A refined analytical model of spatially resolved diffuse reflectance with small source-detector separations (SDSs) for the in vivo skin studies is proposed. Compared to the conventional model developed by Farrell et al., it accounts for the limited acceptance angle of the detector …

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Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy

Mikhail V. Pavlov, Anna P. Bavrina, Vladimir I. Plekhanov, German Yu. Golubyatnikov et autres

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