Darin B. Ostrander

Update: Phase I clinical trial to assess safety, tolerability and feasibility of pNGVL4aCRTE6E7L2 HPV DNA vaccine administration via intramuscular TriGrid™ electroporation delivery system in patients with HPV16-positive high-grade cervical, vulvar or vaginal intraepithelial neoplasia

Kimberly L. Levinson, Rebecca Christian Arend, Tullia Rushton, Peter W. Ketch et autres

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Safety and feasibility of intramuscular pNGVL4a-CRTE6E7L2 and TA-CIN administration for the treatment of patients with HPV16+ atypical squamous cells of unknown significance or low-grade squamous intraepithelial lesion: A phase I clinical trial

Kimberly L. Levinson, Rebecca Christian Arend, Richard B. S. Roden, Tullia Rushton et autres

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A randomized pilot study of HPV16 L2E7E6 fusion protein vaccination site post-treatment for HPV16+ cervical cancer

Stephanie L. Gaillard, Jade Alvarez, Tianbei Zhang, Hao Wang et autres

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Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics

Evan M. Bloch, Tania Jain, Christian A. Merlo, Olga Charnaya et autres

BACKGROUND: Few reports have focused on newer coronavirus disease 2019 (COVID-19) therapies (remdesivir, dexamethasone, and convalescent plasma) in solid organ transplant recipients; concerns had been raised regarding possible adverse impact on allograft function or secondary infections. METHODS: We studied 77 solid organ …

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Longitudinal assessment of the effect of invasive fungal infections on transplant success in kidney transplant recipients

Lucy X. Li, Jiashu Xue, Teresa Po‐Yu Chiang, Na Lu et autres

Invasive fungal infections (IFIs) significantly impact morbidity and mortality in kidney transplant recipients (KTRs), but their effect on allograft function remains poorly defined. This retrospective study examined adult KTRs transplanted at Johns Hopkins from 2012 to 2018, with follow-up through 2023. The …

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P-1033. Post-transplant Outcomes in Kidney Transplant Recipients with Invasive Fungal Infections Prior vs. After the Emergence of SARS-CoV2

Jiashu Xue, Mary G. Bowring, Darin B. Ostrander, Nitipong Permpalung et autres

Abstract Background Invasive fungal infections (IFIs) are a serious complication in kidney transplant recipients (KTRs), leading to increased mortality and graft failure. Given changes in care associated with pandemic conditions and potential compounding effects of COVID-19 infection, we sought to determine whether …

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Safety of Kidney Transplantation from Donors with HIV

Christine M. Durand, Allan B. Massie, Sander S Florman, Tao Liang et autres

BACKGROUND: Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ Policy Equity Act and is currently approved for research only. The Department …

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Phase I clinical trial to assess the safety of pNGVL4aCRTE6E7L2 DNA and TA-CIN protein vaccinations and to seek the appropriate dose of the pNGVL4aCRTE6E7L2 DNA vaccine

Kimberly L. Levinson, Rebecca Christian Arend, Richard B. S. Roden, T.‐C. Wu et autres

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Therapeutic vaccination for the elimination of HPV16+ high-grade dysplasia: A phase I clinical trial of the DNA vaccine pNGVL4aCRTE6E7L2, administered via the TriGrid™ electroporation device

Kimberly L. Levinson, Rebecca Christian Arend, Benjamin J. Matthews, Tullia Rushton et autres

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Building a successful transplant research center: Blueprints and barriers

Christine M. Durand, Michelle Prizzi, Hannah C. Sung, Olivia S. Kates et autres

A successful multidisciplinary research center depends on the quality of the science being conducted and the quality of the center's design, culture, infrastructure, and institutional support. In this perspective, we describe our experience building and maintaining a multidisciplinary transplant research center with …

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Invasive Fungal Infections in Inpatient Solid Organ Transplant Recipients With COVID-19: A Multicenter Retrospective Cohort

Nitipong Permpalung, Teresa Po‐Yu Chiang, Kasama Manothummetha, Darin B. Ostrander et autres

BACKGROUND: The prevalence and outcomes of COVID-19-associated invasive fungal infections (CAIFIs) in solid organ transplant recipients (SOTRs) remain poorly understood. METHODS: A retrospective cohort study of SOTRs with COVID-19 admitted to 5 hospitals within Johns Hopkins Medicine was performed between March 2020 …

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615. A Prospective Cohort Study to Evaluate Performance of MycoMEIA – Aspergillus: A New Urine Diagnostic for Aspergillosis

Nitipong Permpalung, Shakila Rajack, Kieren A. Marr, Kausik Datta et autres

Abstract Background The MycoMEIA urine diagnostic was developed as an enzyme immunoassay, by Johns Hopkins (JH) and Pearl Diagnostics. In a retrospective study of 310 people, the assay was 90.5% (95% CI 70-99) sensitive and 89.2% (95% CI 82-94) specific. We report …

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