Petraleigh Pantoja

Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies

Petraleigh Pantoja, Luis David Giavedoni, Mariah Hassert, Aravinda M. de Silva et autres

Little is known about the contribution of virus-specific and cross-reacting antibodies (Abs) or the cellular immune response generated by a primary dengue (DENV) infection on the course of a secondary zika (ZIKV) infection in vivo. Here we show that the length of …

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The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization

Joshua L. Kennedy, Frances Eun-Hyung Lee, Troy J. Kemp, Lígia A. Pinto et autres

In October 2020, the National Cancer Institute (NCI) Serological Sciences Network (SeroNet) was established to study the immune response to COVID-19, and "to develop, validate, improve, and implement serological testing and associated technologies" (https://www.cancer.gov/research/key-initiatives/covid-19/coronavirus-research-initiatives/serological-sciences-network). SeroNet is comprised of 25 participating research institutions …

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A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity

Deqiu Zhu, Baric R.S, Amila O. De Silva, T Scobey et autres

The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while others are implicated in enhanced viral replication and more severe disease. Current dengue tetravalent vaccines contain four live …

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Immune cell composition varies by age, sex and exposure to social adversity in free-ranging Rhesus Macaques

Mitchell R. Sanchez Rosado, Nicole Marzan-Rivera, Marina M. Watowich, Andrea D. Negron-Del Valle et autres

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A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity

Ellen Young, Boyd L. Yount, Petraleigh Pantoja, Sandra Henein et autres

The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while others are implicated in enhanced viral replication and more severe disease. Current dengue tetravalent vaccines contain four live …

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Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure

Nicole Marzan-Rivera, Crisanta Serrano-Collazo, Lorna Cruz, Petraleigh Pantoja et autres

The link between CD4 + T and B cells during immune responses to DENV and ZIKV and their roles in cross-protection during heterologous infection is an active area of research. Here we used CD4 + lymphocyte depletions to dissect the impact of …

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The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization

Amy B. Karger, James D. Brien, Jayne M. Christen, Santosh Dhakal et autres

SeroNet institutions have developed or implemented 61 diverse COVID-19 serological assays and are collaboratively working to harmonize these assays using reference materials to establish standardized reporting units. This will facilitate clinical interpretation of serology results and cross-comparison of research data.

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The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization

Amy B. Karger, James D. Brien, Jayne M. Christen, Santosh Dhakal et autres

Background: In October 2020, the National Cancer Institute (NCI) Serological Sciences Network (SeroNet) was established to study the immune response to COVID-19, and "to develop, validate, improve, and implement serological testing and associated technologies." SeroNet is comprised of 25 participating research institutions …

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Infection order outweighs the role of CD4+ T cells in tertiary flavivirus infection

Nicole Marzan-Rivera, Crisanta Serrano-Collazo, Lorna Cruz, Petraleigh Pantoja et autres

Abstract Dengue (DENV) and Zika (ZIKV) are flaviviruses that co-circulate throughout the tropical and subtropical regions. The link between CD4+ T and B cells during immune responses to DENV and ZIKV and their roles in cross-protection during heterologous infection is an active …

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P566 Humoral immune response to mRNA COVID-19 vaccine in Puerto Ricans with IBD does not differ between class of biologics

P López Marte, Lizzie M. Ramos-Tollinchi, E Rodriguez-Martinó, Rafael Medina-Prieto et autres

Abstract Background The COVID-19 vaccine trials did not include subjects with IBD or immunosuppression, limiting the effectiveness data of the vaccine in this population. The impact of biologics with different mechanisms of action on antibody concentrations and neutralizing capacity produced by the …

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Infection Order Outweighs the Role of CD4 + T Cells in Tertiary Flavivirus Infection

Nicole Marzan-Rivera, Crisanta Serrano-Collazo, Lorna Cruz, Petraleigh Pantoja et autres

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Age, sex, and social environmental effects on immune cell composition in a free-ranging non-human primate

Mitchell R. Sanchez Rosado, Nicole Marzan-Rivera, Marina M. Watowich, Andrea D. Negron-Del Valle et autres

Abstract Increasing age is associated with dysregulated immune function and increased inflammation– patterns that are also observed in individuals exposed to chronic social adversity. Yet we still know little about how social adversity impacts the immune system and how it might promote …

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