Age, sex, and social environmental effects on immune cell composition in a free-ranging non-human primate
Rattachement africain : pr, us, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Increasing age is associated with dysregulated immune function and increased inflammation– patterns that are also observed in individuals exposed to chronic social adversity. Yet we still know little about how social adversity impacts the immune system and how it might promote age-related diseases. Here, we investigated how immune cell diversity varied with age, sex and social adversity (operationalized as low social status) in free-ranging rhesus macaques. We found age-related signatures of immunosenescence, including lower proportions of CD20+ B cells, CD20+/CD3+ ratio, and CD4+/CD8+ T cell ratio – all signs of diminished antibody production. Age was associated with higher proportions of CD3+/CD8+ Cytotoxic T cells, CD16+/CD3-Natural Killer cells, CD3+/CD4+/CD25+ and CD3+/CD8+/CD25+ T regulatory cells, and CD14+/CD16+/HLA-DR+ intermediate monocytes, and lower levels of CD14+/CD16-/HLA-DR+ classical monocytes, indicating greater amounts of inflammation and immune dysregulation. We also found an effect of exposure to social adversity (i.e., low social status) that was sex-dependent. High-status males, relative to females, had higher CD20+/CD3+ ratios and CD16+/CD3 Natural Killer cell proportions, and lower proportions of CD8+ Cytotoxic T cells. Further, low status females had higher proportions of cytotoxic T cells than high status females, while the opposite was observed in males. High status males had higher CD20+/CD3+ ratios than low status males. Together, our study identifies immune cell types that differ by age in a human-relevant primate model animal, and demonstrates a novel link between sex-dependent immunity and social adversity.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Age, sex, and social environmental effects on immune cell composition in a free-ranging non-human primate
- Date Crossref
- 07/12/2021
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Puerto Rico Department of Microbiology & Medical Zoology pays non établi dans la noticeUniversité ou école supérieure
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University of Washington Department of Biology pays non établi dans la noticeUniversité ou école supérieure
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Arizona State University School for Human Evolution and Social Change pays non établi dans la noticeUniversité ou école supérieure
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University of Exeter Centre for Research in Animal Behaviour pays non établi dans la noticeUniversité ou école supérieure
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New York University Department of Anthropology pays non établi dans la noticeUniversité ou école supérieure
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University of Pennsylvania Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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School of Life Sciences Center for Evolution and Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Microbiology & Medical Zoology — University of Puerto Rico, Department of Biology — University of Washington et School for Human Evolution and Social Change — Arizona State University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.