Fatima Zemali

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot et autres

OBJECTIVES: Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to …

fr, au (code pays fourni par la source)

Individualized vs Standard Blood Pressure Control During Thrombectomy for Ischemic Stroke

Benjamin Maïer, Benjamin Gory, Russell Chabanne, B. Tavernier et autres

BACKGROUND AND OBJECTIVES: Current recommended blood pressure (BP) targets during mechanical thrombectomy (MT) rely on a one-size-fits-all approach aiming at preventing hypertension. The efficacy and safety of an individualized BP control during thrombectomy for ischemic stroke has not been well studied. We …

fr (code pays fourni par la source)

Platelets mediate fibrin-induced thromboinflammation and NETosis through a GPVI-polyphosphate-FXIIa procoagulant axis

Astride Perrot, Véronique Ollivier, Sandrine Delbosc, Fatima Zemali et autres

Fibrin deposits drive thromboinflammation and neutrophil extracellular trap (NET) formation (NETosis) in various pathophysiological situations, but the underlying mechanisms remain unclear. Similarly, it is unknown how, irrespective of diabetes, hyperglycemia exacerbates thromboinflammation. Using a microfluidic model of thromboinflammation based on the perfusion …

fr (code pays fourni par la source)

ABSTRACT NUMBER: ESOC2026A756 ACUTE SEPSIS INCREASES HEMORRHAGIC TRANSFORMATION AND WORSENS OUTCOME AFTER EXPERIMENTAL ISCHEMIC STROKE IN MICE

Fatima Zemali, Sébastien Dupont, Lucas Di Meglio, Jean Philippe Desilles et autres

Abstract Background and aims Systemic infections are independently associated with poor outcome after ischemic stroke. Hemorrhagic transformation (HT) represents a major cause of neurological worsening. Although sepsis is known to exacerbate stroke severity, its role in promoting HT and the contribution of …

fr (code pays fourni par la source)

Piezo1 gain of function induces a platelet preactivation state

Bachelot-Loza Christilla, Aurore Marchelli, Laurie Ruch, Divina El Hamaoui et autres

fr (code pays fourni par la source)

Neutrophil extracellular traps-targeting therapy with deoxyribonuclease 1 reduces large vessel occlusion-induced downstream microvascular thromboinflammation in a rat model of stroke

Lucas Di Meglio, Mialitiana Solo Nomenjanahary, Laurine Bedoucha, Sébastien Dupont et autres

Background: Neutrophil activation and neutrophil extracellular traps (NETs) participate in downstream microvascular thromboinflammation (DMT) and blood brain barrier disruption in acute ischemic stroke (AIS). Objectives: The aim of this study was to test whether deoxyribonuclease 1 (DNase 1) infusion, which cleaves extracellular …

fr (code pays fourni par la source)

Fibrinogen Depletion Coagulopathy and Hemorrhagic Transformation in Acute Ischemic Stroke Treated With Bridging Therapy

Naëiri Pauillac, Dorothée Faille, Mialitiana Solo Nomenjanahary, Mélanie Souvanheuane et autres

BACKGROUND: Hemorrhagic transformation (HT) frequently occurs in acute ischemic stroke patients with a large vessel occlusion undergoing endovascular therapy (EVT), significantly impacting functional outcomes. We aimed to determine whether an early fibrinogen depletion coagulopathy (FDC) was associated with HT following bridging therapy …

fr, be (code pays fourni par la source)

Neutrophil extracellular traps block endogenous and intravenous thrombolysis-induced fibrinolysis in large vessel occlusion acute ischemic stroke

Jean‐Philippe Désilles, Mialitiana Solo Nomenjanahary, Lucas Di Meglio, Fatima Zemali et autres

Abstract Background Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is frequent but its causes remain elusive. Several non-exclusive mechanisms have been proposed to explain IVT failure, including failed delivery of tPA and inhibition of …

fr, ca (code pays fourni par la source)

Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage

Sébastien Dupont, Héloïse Lebas, Sabrina Mavouna, E Pascal et autres

BACKGROUND: Antiplatelet drugs represent potential candidates for protecting the penumbral microcirculation during cerebral ischemia and improving the benefits of arterial recanalization in ischemic stroke. Yet while the efficacy of such adjuvant strategies has been shown to be highly time dependent, antiplatelet therapy …

fr, de (code pays fourni par la source)