Extensive exposure to di-n-hexyl phthalate with significant seasonal variation across infants, children and adults including pregnant women in Denmark
Rattachement africain : dk, de. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Di-n-hexyl phthalate (DnHxP) is one of the most potent phthalates with adverse effects on the male reproductive system. Despite a European ban on DnHxP since 2020, high urinary excretion of mono-n-hexyl phthalate (MnHxP), the major metabolite of DnHxP, has been observed in recent European human biomonitoring (HBM) studies. Sunscreen products containing the UV-filter diethylamino hydroxybenzyl hexyl benzoate (DHHB), which can be contaminated with DnHxP, were pointed out as a relevant source of exposure to DnHxP. OBJECTIVE: To study possible seasonal variation in urinary excretion of MnHxP in different Danish study populations. METHOD: MnHxP was measured by LC-MS/MS in 1591 urine samples collected in 2016-2022 from pregnant women, 7-year-old children, and infants and their parents participating in three different cohort studies. RESULTS: Urinary MnHxP was above the limit of detection (0.04 μg/L) in 84 % and above 1 μg/L in 33 % of samples. The 7-year-old children was the study population with the highest excretion rate (97 %). The highest urinary MnHxP concentration (72.5 μg/L) exceeded the health-based guidance value (HBM-I value) of 60 μg/L. A significantly higher urinary excretion of MnHxP was observed in the summer compared to the winter season in all study populations. 80 % of the urine samples with MnHxP concentrations > 1 μg/L were from the summer season. 40 % of Danish sunscreen products contain DHHB. CONCLUSION: The marked seasonal variation with higher MnHxP excretions in the summer season supports the hypothesis that the recently unveiled DnHxP contamination of the UV-filter DHHB in sunscreen products could be driving these exposures.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Extensive exposure to di-n-hexyl phthalate with significant seasonal variation across infants, children and adults including pregnant women in Denmark
- Date Crossref
- 01/07/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Copenhagen University Hospital Department of Growth and Reproduction pays non établi dans la noticeÉtablissement de santé
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Rigshospitalet pays non établi dans la noticeÉtablissement de santé
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Institute for Prevention and Occupational Medicine pays non établi dans la noticeStructure de recherche
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Danish Refugee Council pays non établi dans la noticeOrganisation à but non lucratif
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Danish Agriculture and Food Council pays non établi dans la noticeOrganisme public
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Odense University Hospital pays non établi dans la noticeOrganisme public
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The Danish Consumer Council THINK Chemicals (DCC) pays non établi dans la noticeInstitution
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University of Southern Denmark Department of Clinical Pharmacology pays non établi dans la noticeUniversité ou école supérieure
Department of Growth and Reproduction — Copenhagen University Hospital, Rigshospitalet et Institute for Prevention and Occupational Medicine, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.