Shejuan An

The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma

Matthew McCord, Thomas Sears, Wenxia Wang, Rahul K. Chaliparambil et autres

BACKGROUND: Acquired resistance to temozolomide (TMZ) chemotherapy due to DNA mismatch repair (MMR) enzyme deficiency is a barrier to improving outcomes for isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) patients. KL-50 is a new imidazotetrazine-based therapeutic designed to induce DNA interstrand cross-links, and …

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Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report

Batel Blechter, Chao A. Hsiung, Xiaoyu Wang, Haoyu Zhang et autres

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EXTH-23. NEW DNA-CROSSLINKING CHEMOTHERAPY IS EFFECTIVE AGAINST POST-TEMOZOLOMIDE MISMATCH REPAIR-DEFICIENT PATIENT-DERIVED HYPERMUTANT GLIOMAS

Matthew McCord, Wenxia Wang, Shejuan An, Thomas Sears et autres

Abstract The DNA mismatch repair (MMR) pathway triggers glioblastoma (GBM) apoptosis when base mismatches induced by the alkylating agent temozolomide (TMZ) cannot be repaired. GBMs often develop hypermutation and resistance to TMZ through acquired inactivation of DNA MMR enzymes (MSH2, MSH6, MLH1, …

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BIOM-19. METHYLATION PROFILING OF PLASMA CELL-FREE DNA IN PEDIATRIC BRAIN TUMOR PATIENTS

Shejuan An, Kathleen McCortney, Jordain Walshon, Kaethe Leonard et autres

Abstract BACKGROUND Circulating tumor DNA (ctDNA) assays are being evaluated to inform clinical decisions in cancer care in adult patients, but the study in pediatric brain tumor patients is rare partly due to very low levels of ctDNA in blood. Currently, treatment …

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DDEL-12. LOCAL DELIVERY OF CHEMOTHERAPIES VIA BIORESORBABLE IMPLANT IN MENINGIOMAS

Mark W. Youngblood, Ziying Hu, Khizar R. Nandoliya, Vineeth Thirunavu et autres

Abstract Many meningiomas recur despite repeated surgical resections and radiation, and patients must undergo progressively morbid surgical procedures due to recurrent or progressive disease. However, unlike most gliomas, meningiomas do not diffusely infiltrate throughout the brain on a single-cell basis, but instead …

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Methylation profiling of plasma cell-free DNA in pediatric brain tumor patients

Shejuan An, Kathleen McCortney, Jordain Walshon, Kaethe Leonard et autres

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DIPG-02. LIN28B EXPRESSION IN DIFFUSE MIDLINE GLIOMA

Truman Knowles, Shejuan An, Tina Huang, Jin Qi et autres

Abstract BACKGROUND Diffuse midline glioma (DMG) is the most lethal of all childhood cancers. LIN28B is a RNA binding protein expressed in a variety of cancers, which suppresses the let-7 family of microRNAs, which in turn suppresses a plethora of oncogenes. However, …

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134 LIN28B as a Novel Therapeutic Target in Diffuse Midline Glioma

Truman Knowles, Tina Huang, Shejuan An, Qi Jin et autres

INTRODUCTION: Diffuse midline glioma (DMG) is the most lethal of all childhood cancers. LIN28B is a RNA binding protein expressed in a variety of cancers, which suppresses the let-7 family of microRNAs, which in turn suppresses a plethora of oncogenes. However, the …

CSIG-11. LIN28B EXPRESSION IN DIFFUSE MIDLINE GLIOMA

Truman Knowles, Shejuan An, Tina Huang, Jin Qi et autres

Abstract INTRODUCTION Diffuse midline glioma (DMG) is the most lethal of all childhood cancers. LIN28B is a RNA binding protein expressed in a variety of cancers, which suppresses the let-7 family of microRNAs, which in turn suppresses a plethora of oncogenes. However, …

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LIN28B and Let-7 in Diffuse Midline Glioma: A Review

Truman Knowles, Tina Huang, Jin Qi, Shejuan An et autres

Diffuse midline glioma (DMG) is the most lethal of all childhood cancers. DMGs are driven by histone-tail-mutation-mediated epigenetic dysregulation and partner mutations in genes controlling proliferation and migration. One result of this epigenetic and genetic landscape is the overexpression of LIN28B RNA …

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DIPG-01. LIN28B EXPRESSION IN DIFFUSE MIDLINE GLIOMA

Truman Knowles, Shejuan An, Tina Huang, Qi Jin et autres

Abstract INTRODUCTION Diffuse midline glioma (DMG) is the most lethal of all childhood cancers. LIN28B is an RNA binding protein expressed in a variety of cancers, which suppresses the let-7 family of microRNAs, which in turn suppresses a plethora of oncogenes. However, …

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo et autres

Abstract Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 …

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