Matthew McCord

The cross-talk between prolactin and growth hormone in pituitary adenomas

Erica Giraldi, Matthew McCord, Adriana G. Ioachimescu

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Intracranial solitary fibrous tumor with myxoid features: An unusual presentation

Anna Vi Jones, M Beatriz S Lopes, Sohil H. Patel, Ashok Asthagiri et autres

To the Editor: Solitary fibrous tumor (SFT), formerly known as hemangiopericytoma, is a mesenchymal neoplasm that may occur in the CNS, among numerous other locations. Classically, SFT shows spindled to ovoid cells in a collagenous background with branching “staghorn” blood vessels. The …

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Belzutifan-induced tumor regression in sporadic hemangioblastoma: a case report and literature review

Rebekka E Hooks, Niket Yadav, Mark Willy L. Mondia, Georgios Mantziaris et autres

BACKGROUND: Sporadic hemangioblastomas (sHBs) are less prevalent than those in von Hippel-Lindau (VHL) disease. Surgical resection and radiation therapy remain the standard treatments, and medical treatment options for sHBs are limited. While belzutifan shows a favorable response in VHL-associated HBs, its efficacy …

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Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas

Drew Duckett, Santana-Santos Lucas, Matthew McCord, Vanessa Smith et autres

Meningiomas are common intracranial tumors with complex behavior that can be difficult to predict. Historically, morphology has been used to predict tumor aggressiveness and risk of recurrence, but this strategy has limitations as a prognostic tool. DNA methylation, transcriptomics, and copy number …

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Radiolabeling molecular biomarkers of invasive pituitary adenomas: a narrative review

Charbel Marche, Shivashankar Khanapur, Eric Suero Molina, Matthew McCord et autres

PURPOSE: Pituitary adenoma, are common intracranial neoplasms that can exhibit invasive behavior, leading to increased morbidity, recurrence, and resistance to treatment. Identifying biomarkers associated with tumor invasiveness could improve early diagnosis and guide therapeutic interventions. This review evaluates molecular biomarkers linked to …

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Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high-grade IDH mutant gliomas

Thomas Sears, Matthew McCord, Wenxia Wang, Alicia Steffens et autres

IDH1/2 mutations (IDHmut) increase methylation of DNA and histones in gliomas. IDHmut inhibitors are effective against low-grade IDHmut gliomas, but new strategies against high-grade IDHmut gliomas are needed. Although histone deacetylase inhibitors (HDACi) are ineffective against IDHwt glioblastoma (GBM), their potential in …

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Rapid assessment of MGMT promoter methylation status by droplet digital polymerase chain reaction on intraoperative smear preparation: A proof-of-concept study

Zachary Coty‐Fattal, Heather Smith, Matthew McCord, Melissa Mejía-Bautista et autres

MGMT promoter methylation is an important predictor of response to chemotherapy in adult-type diffuse gliomas. Currently, MGMT promoter methylation assessment requires formalin-fixed, paraffin-embedded (FFPE) tissue. We developed a droplet digital PCR (ddPCR) MGMT assay performed on bisulfite converted DNA utilizing primers targeting …

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Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas

Drew Duckett, Lucas Santana‐Santos, Matthew McCord, Vanessa Smith et autres

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Radiolabeling Molecular Biomarkers of Invasive Pituitary Neuroendocrine Tumors: A Systematic Review

Shivashankar Khanapur, Eric Suero Molina, Matthew McCord, Vanessa Smith et autres

Abstract Objective Pituitary neuroendocrine tumors (PitNETs) are common intracranial neoplasms that can exhibit invasive behavior, leading to increased morbidity, recurrence, and resistance to treatment. Identifying biomarkers associated with tumor invasiveness could improve early diagnosis and guide therapeutic interventions. This systematic review evaluates …

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197 Integrating Histologic and Molecular Features in Meningiomas

Harrshavasan Congivaram, Vineeth Thirunavu, Lucas Santana‐Santos, Pouya Jamshidi et autres

INTRODUCTION: Histologic findings are the primary determinant of meningioma prognosis and post-operative management. However, the relationship of specific pathologic features to molecular alterations has not yet been comprehensively investigated. METHODS: Detailed histological information was collected for 809 resected meningiomas, including cases with …

1526 Predicting Meningioma Recurrence with Methylation Profiling

Matthew McCord, Drew Duckett, Lucas Santana‐Santos, Lawrence J. Jennings et autres

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F3 Expression Drives Sensitivity to the Antibody-Drug Conjugate Tisotumab Vedotin in Glioblastoma

Thomas Sears, Wenxia Wang, Michael Drumm, Dusten Unruh et autres

Background/Objectives: The gene F3, encoding Tissue Factor (TF), is expressed in many cancers and contributes to their malignancy. Among adult-type diffuse gliomas, IDH1/2 wild-type (IDHwt) glioblastomas (GBM) express more TF than IDH1/2 mutant (IDHmut) gliomas. Tisotumab vedotin (TisVed), an anti-TF antibody conjugated …

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