Katsuki Takebe

Protein fractions associated with Prevotella intermedia suppress the growth of HSC-3 oral squamous cell carcinoma cells

Miyuki Kashiwabara, Machiko Kasai, Shintaro Nakano, Katsuki Takebe et autres

OBJECTIVES: Oral microbiomes are associated with the progression of oral squamous cell carcinoma (OSCC). Prevotella intermedia is associated with tumor progression; however, the direct effects of P. intermedia on OSCC cells have not been elucidated. In this study, the aim was to …

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MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama et autres

ABSTRACT Methionine biosynthesis is essential for Mycobacterium tuberculosis , but the in vivo relevance of individual enzymes remains unclear. We performed transposon sequencing in Mycobacterium bovis BCG under methionine‐free conditions and identified metF as a major fitness determinant. To define enzyme‐specific functions, …

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Source data for: ThyX-Overexpressing Mycobacterium bovis BCG Shows Rapid Growth by Shortening the Folate Pathway

Ayako Ryumon, Katsuki Takebe, Ikue Tosa, Goro Matsuzaki et autres

This repository contains the source data and original image files used to generate Figures 1–5 and Figure S2 of the manuscript entitled “ThyX-Overexpressing Mycobacterium bovis BCG Shows Rapid Growth by Shortening the Folate Pathway.” RNA sequencing data have been deposited separately in …

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Source data for: ThyX-Overexpressing Mycobacterium bovis BCG Shows Rapid Growth by Shortening the Folate Pathway

Ayako Ryumon, Katsuki Takebe, Ikue Tosa, Goro Matsuzaki et autres

This repository contains the source data and original image files used to generate Figures 1–5 and Figure S2 of the manuscript entitled “ThyX-Overexpressing Mycobacterium bovis BCG Shows Rapid Growth by Shortening the Folate Pathway.” RNA sequencing data have been deposited separately in …

jp (code pays fourni par la source)

Bacterial collagenase harnesses collagen geometry for processive cleavage

Hiroya Oki, Katsuki Takebe, Adjoa O. Bonsu, Kazunori K. Fujii et autres

Collagen, the major structural protein in the animal extracellular matrix, forms a triple helix that resists proteolysis and requires specialised enzymes for degradation. Flesh-eating bacteria secrete collagenases that unwind the collagen triple helix and processively trim Gly-X-Y triplet repeats, yet the molecular …

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Correction: MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer

Takanori Eguchi, Eman Ahmed Taha, Keisuke Nakano, Vikas Kumar Tiwari et autres

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MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer

Takanori Eguchi, Eman Ahmed Taha, Keisuke Nakano, Vikas Kumar Tiwari et autres

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. MMPs have also been found in extracellular vesicles (EVs), such as exosomes. MMP-3 …

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Additional file 1 of MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer

Takanori Eguchi, Eman Ahmed Taha, Keisuke Nakano, Vikas Kumar Tiwari et autres

Supplementary Material 1: Figure S1. Uncropped raw images of TEM of LuM1 tumoroid EVs and MMP3-KO EVs. Figure S2. Gene expression levels of MMP3 and LMNA positively correlated in clinical tumor specimens of HNSC and pancreatic adenocarcinoma. Figure S3. Original WB images …

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Additional file 1 of MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer

Takanori Eguchi, Eman Ahmed Taha, Keisuke Nakano, Vikas Kumar Tiwari et autres

Supplementary Material 1: Figure S1. Uncropped raw images of TEM of LuM1 tumoroid EVs and MMP3-KO EVs. Figure S2. Gene expression levels of MMP3 and LMNA positively correlated in clinical tumor specimens of HNSC and pancreatic adenocarcinoma. Figure S3. Original WB images …

jp, Égypte, cn, us (code pays fourni par la source)

MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer

Takanori Eguchi, Eman Ahmed Taha, Keisuke Nakano, Vikas Tiwari et autres

Abstract Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. MMPs have also been found in extracellular vesicles (EVs), such as exosomes. …

jp, Égypte, cn, us (code pays fourni par la source)

MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer

Takanori Eguchi, Eman Ahmed Taha, Keisuke Nakano, Vikas Tiwari et autres

Abstract Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. MMPs have also been found in extracellular vesicles (EVs), such as exosomes. …

jp, Égypte, cn, us (code pays fourni par la source)

Insights into the taste of organic acids via TAS1Rs

Yuko Yamase, Katsuki Takebe, Kengo Horie, Yoshihiro Mitoh et autres

OBJECTIVES: Organic acids contribute significantly to the flavor of fermented foods by imparting sourness. Although mice generally avoid sour taste, previous studies have reported greater consumption of l-lactic acid than its d-enantiomer, suggesting enantiomer-specific recognition. This behavior is hypothesized to involve TAS1Rs, …

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