Shintaro Nakano

Protein fractions associated with Prevotella intermedia suppress the growth of HSC-3 oral squamous cell carcinoma cells

Miyuki Kashiwabara, Machiko Kasai, Shintaro Nakano, Katsuki Takebe et autres

OBJECTIVES: Oral microbiomes are associated with the progression of oral squamous cell carcinoma (OSCC). Prevotella intermedia is associated with tumor progression; however, the direct effects of P. intermedia on OSCC cells have not been elucidated. In this study, the aim was to …

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A phase II trial of ramucirumab and docetaxel as second-line treatment for patients with advanced gastric cancer (HGCSG 1903)

Yasuyuki Kawamoto, Kentaro Sawada, Kazuaki Harada, Iori Motoo et autres

BACKGROUND: Ramucirumab has shown efficacy in combination with paclitaxel in the second-line treatment of advanced gastric cancer (AGC). The efficacy and safety regarding the combination therapy of ramucirumab and docetaxel have not been reported. This treatment could reduce the incidence of neuropathy …

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Pacing Ratio Changes of an Implanted Permanent Pacemaker After Transcatheter Aortic Valve Implantation

Yu Fukuoka, Yoshifumi Ikeda, Hitoshi Mori, Keisuke Matsuo et autres

BACKGROUND: In some patients, transcatheter aortic valve implantation (TAVI) is associated with conduction disturbances, necessitating permanent pacemaker implantation (PMI). The clinical course of conduction disturbances after PMI, based on the type of TAVI valve, remains unclear. Therefore, the present study aimed to …

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Mid-Term Clinical Outcomes and Hemodynamic Performance of 19-mm Bioprostheses Following Aortic Valve Replacement ― A Single-Institution 10-Year Experience ―

Takayuki Gyoten, Yuta Kanazawa, Yu Kumagai, Takayuki Akatsu et autres

Background: Data on the clinical outcomes and hemodynamic performance of the smallest commercially available bioprostheses (19 mm) in Japan for aortic valve replacement (AVR) remain limited. Methods and Results: We analyzed the data of 187 adults (median age, 76 [interquartile range (IQR): …

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Induction of apoptotic cell death by calcitriol in RAW264.7 cells

Machiko Kasai, Shintaro Nakano, Keisuke Nakamura, Tsukasa Akasaka et autres

Vitamin D affects bone and mineral metabolism and immunity. Epidemiological data suggests that vitamin D may play a role in the development and progression of cancer. Additionally, calcitriol, an active form of vitamin D, has an antiproliferative effect on malignant tumo rs. …

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Transcatheter Aortic Valve Implantation via the Right Subclavian Artery for Chronic Type A Aortic Dissection

Yuto Hori, Takahide Arai, Shintaro Nakano, Akihiro Yoshitake

BACKGROUND: Transcatheter aortic valve implantation (TAVI) in patients with chronic type A aortic dissection (CTAAD) is rare, and the optimal strategy remains undefined. CASE SUMMARY: An 86-year-old woman with symptomatic severe aortic stenosis underwent preprocedural computed tomography for TAVI before scheduled gastric …

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Stent Fracture of Biolimus‐Eluting Stent (Biofreedom) Complicated With Micro‐Coronary Artery Aneurysm

Takahide Arai, Hiroki Hoya, Shintaro Nakano

Coronary stent fractures (SFs) are an emerging complication of coronary stents. There are numerous risk factors for SF, which include vessel angulation, use of sirolimus-eluting stent (SES), long stents, multiple stent layers, stent overlap, inflammation, hypersensitivity, stenting in the right coronary artery, …

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Results of a multicenter retrospective cohort study evaluating the safety and efficacy of FTD/TPI plus ramucirumab in advanced gastric cancer (HGCSG2302).

Ayumu Yoshikawa, Takeaki Nakamura, Kentaro Sawada, Atsushi Ishiguro et autres

351 Background: In advanced gastric cancer, trifluridine/tipiracil (FTD/TPI) is one of the standard treatments for later-line chemotherapy. Ramucirumab (RAM), an anti-VEGFR-2 monoclonal antibody, has shown promising efficacy in combination with FTD/TPI in phase II studies conducted in Japan, suggesting that this combination …

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Association between Mobility of Residual Left Atrial Thrombus and Stroke Severity in Patients with Nonvalvular Atrial Fibrillation

Yuji Kato, Takeshi Hayashi, Shintaro Nakano, Takahide Arai et autres

BACKGROUND: The differences in the characteristics of ischemic stroke associated with a mobile versus nonmobile residual left atrial thrombus (LAT) are unclear. We investigated whether the mobility of an LAT detected by transthoracic echocardiography is associated with the clinical features of stroke. …

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Nonspecific inflammatory pseudotumor of the maxillary and temporal fossa: a study of seven cases

Wataru Kakuguchi, Yuichi Ashikaga, Yasuhito Moritani, Shintaro Nakano et autres

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Epithelial-mesenchymal transition in oral cancer cells induced by prolonged and persistent Fusobacterium nucleatum stimulation

Shintaro Nakano, Machiko Kasai, Keisuke Nakamura, Tsukasa Akasaka et autres

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Fusobacterium nucleatum の慢性感染による口腔癌細胞の上皮間葉転換

Shintaro Nakano

Objectives: Although several studies have reported the effects of Fusobacterium nucleatum infection in oral cancer cells, the cell infection period ranges from three days to a maximum of eight days. Therefore, the in vitro studies conducted to date may not be enough …