Maria Corona

A Machine Learning Approach to Predict Cognitive Decline in Alzheimer Disease Clinical Trials

Bhargav Teja Nallapu, Kellen K. Petersen, Tianchen Qian, İdris Demirsoy et autres

BACKGROUND AND OBJECTIVES: Among the participants of Alzheimer disease (AD) treatment trials, 40% do not show cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals can increase power to detect treatment effects. We aimed to develop machine learning-based predictive …

us, tr (code pays fourni par la source)

Deep learning to quantify the pace of brain aging in relation to neurocognitive changes

Chenzhong Yin, Phoebe E. Imms, Nahian F. Chowdhury, Nikhil N. Chaudhari et autres

Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since birth. Thus, it conveys poorly recent or contemporaneous …

us (code pays fourni par la source)

Learning-based inference of longitudinal image changes: Applications in embryo development, wound healing, and aging brain

Heejong Kim, Batuhan K. Karaman, Qingyu Zhao, Alan Q. Wang et autres

Longitudinal imaging data are routinely acquired for health studies and patient monitoring. A central goal in longitudinal studies is tracking relevant change over time. Traditional methods remove nuisance variation with custom pipelines to focus on significant changes. In this work, we present …

us, ca, jp (code pays fourni par la source)

Community recruitment of underrepresented populations to a preclinical AD trial using novel partnerships with nursing organizations: Lessons and outcomes

Christian R. Salazar, Melanie B Tallakson, Maria Corona, Edwin Duran et autres

Abstract Background Alzheimer’s disease (AD) disproportionately affects minoritized populations, who are consistently underrepresented in clinical trials. We aimed to recruit underrepresented adults aged 55‐80 to an ongoing preclinical AD trial. Method A community‐based strategy was used to recruit Filipino, Hispanic/Latino, and Korean …

us (code pays fourni par la source)

Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment

Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca et autres

White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH …

de, nl, us, at, ch, sg, ca (code pays fourni par la source)

Towards cascading genetic risk in Alzheimer’s disease

André Altmann, Leon Aksman, Neil P. Oxtoby, Alexandra L. Young et autres

Alzheimer's disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: amyloid (A), tau (T) and neurodegeneration (N). This progression of biomarkers has been condensed into the ATN framework, in which each of the biomarkers can be …

gb, us (code pays fourni par la source)

C-07 Global Precedence: Examining Contributing Effects of Age and Cognitive Functioning

Michele M. Johnson, Ji Lai, Maria Corona, Garima J. Lupas

Abstract Objective Global precedence (GP) is an individual’s ability to readily identify global (gestalt) features when both global and local (internal) details are presented. Prior research shows that both age and neurodegenerative diseases, such as Alzheimer’s, affect GP. The goal of the …

Concomitant deletion of chromosome 16p13.11 and triplication of chromosome 19p13.3 in a child with developmental disorders, intellectual disability, and epilepsy

Elisa Tassano, Lucia De Santis, Maria Corona, Stefano Parmigiani et autres

BACKGROUND: Rare copy number variations (CNVs) are today recognized as an important cause of various neurodevelopmental disorders, including mental retardation and epilepsy. In some cases, a second CNV may contribute to a more severe clinical presentation. RESULTS: Here we describe a patient …

it (code pays fourni par la source)

Bruising as a Forensic Marker of Physical Elder Abuse

Aileen Wiglesworth, Raciela Austin, Maria Corona, Laura A. Mosqueda

Bruising as a Marker of Physical Elder Abuse

Aileen Wiglesworth, Raciela Austin, Maria Corona, Diana Cafaro Schneider et autres

OBJECTIVES: To describe bruising as a marker of physical elder abuse. DESIGN: Consenting older adults were examined to document location and size of bruises and assess whether they were inflicted during physical abuse. An expert panel confirmed physical abuse. Findings were compared …

us (code pays fourni par la source)

ERP correlates of the incidental retrieval of emotional information: Effects of study-test delay

Antônio Jaeger, Jeffrey D. Johnson, Maria Corona, Michael D. Rugg

br, us (code pays fourni par la source)

BRAIN RHYTHM ANALYSIS ON SIMULTANEOUS MEGEEG RECORDINGS DURING MENTAL TASK

Rocco Mammoliti, Monica Puligheddu, Matteo Fraschini, Jan Casper de Munck et autres