Ye Cheng

Epidemiology of neurological diseases in China: Key insights from the 2024 report of the National Center for Neurological Disorders

Yicong Lin, Linzi Song, Yi Tang, Xue Wang et autres

Neurological disorders pose a severe public health challenge in China, with substantial impacts on mortality, disability, and socioeconomic burden, especially in the context of population aging. This study synthesizes key findings from the China Neurological Disorders Report 2024 (compiled by the National …

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Phenotypic, Genotypic Characteristics, and Treatment Strategies of Pediatric Tyrosine Hydroxylase Deficiency: A Single‐Center Retrospective Analysis of 51 Cases

Tingting Ban, Ye Cheng, Yan Zhang, Caimei Lin et autres

BACKGROUND: Tyrosine hydroxylase deficiency (THD) is a rare autosomal recessive disorder caused by impaired catecholamine biosynthesis in the brain. The rarity and heterogeneous clinical spectrum of THD often lead to misdiagnosis, and evidence-based, genotype-specific levodopa dosing protocols remain unavailable. OBJECTIVE: To delineate …

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A prediction nomogram for refractory septic shock children on ECMO support: A prospective cohort study

Ye Cheng, Hengmiao Gao, Yingfu Chen, Wei Xu et autres

Background: To study the prognostic factors of extracorporeal membrane oxygenation (ECMO) intervention for children with refractory septic shock (RSS), and to develop a predictive model to assist physician’ ECMO decision-making in clinical work. Methods: Relevant indicators of children with RSS, who were …

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A novel mechanism involving USP53-regulated BSEP trafficking underlies low-GGT intrahepatic cholestasis

Jian Ping Ding, Ye Cheng, Jia‐Yan Feng, Teng Liu et autres

BACKGROUND AND AIMS: USP53 variants cause low-GGT progressive familial intrahepatic cholestasis (PFIC). The mechanism is not well understood. USP53, which encodes a ubiquitin-specific protease, has been proposed to be involved in blood-bile barrier impairment. However, Usp53 knockout mice did not show blood-bile …

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Global burden of amputation among children and adolescents from 1990 to 2021: systematic analysis of the Global Burden of Disease study 2021

Qingsong Chen, Hui Li, Wenjuan Du, Boyu Li et autres

Introduction: Amputation among children and adolescents, with its substantial physical, psychological, and economic impacts, remains a significant global health issue. Objectives: This study uses data from the Global Burden of Disease (GBD) to examine trends in amputation burden among youth aged 0-19 …

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Evaluating the Diagnostic and Prognostic Value of Peripheral Immune Markers in Glioma Patients: A Prospective Multi-Institutional Cohort Study of 1282 Patients

Jie Lu, Zhiyun Zhang, Sheng Wei Zhong, Davy Deng et autres

Objective: Glioma is the most common primary brain tumor, with a specific immune microenvironment and aggressive nature. Novel systemic immune-inflammation indices (nSII) are the most comprehensive non-invasive biomarkers that represent patients’ peripheral immune status, which are urgently needed to improve clinical management. …

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Crosstalk of autophagy and ferroptosis in cardiovascular diseases: from pathophysiology to novel therapy

Changhao Hu, Xinyi Li, Kaiqing Yang, Ye Cheng et autres

Cardiovascular diseases (CVDs) are characterized by high morbidity and mortality rates, imposing substantial epidemiological and economic burdens worldwide. Among the multifaceted mechanisms implicated in CVDs, autophagy and ferroptosis, two intimately linked cellular processes, emerge as pivotal pathophysiological contributors. Autophagy, as an evolutionary …

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Effects of Interactive Health Education Combined With Evidence-based Pain Management Nursing on Disease Cognition, Postoperative Pain and Post-traumatic Growth in Patients Undergoing Laparoscopic Salpingectomy

Ye Cheng, Lixia Li, Yew Yoong Ding

AIM: Laparoscopic salpingectomy has been widely used in the clinical treatment of benign tubal lesions. This study aims to explore the effects of interactive health education combined with evidence-based pain management nursing on disease cognition, postoperative pain and post-traumatic growth in patients …

[A multicenter retrospective study of secondary transport on extracorporeal membrane oxygenation in critically ill children].

Zhenping Zhao, Ye Cheng, Xiaohua Wu, Yuan Liu et autres

Secondary ECMO transport for critically ill children don't increase mortality or life-threatening complications during transport. ECMO patients who cannot receive effective treatment locally can benefit from secondary transport to an advanced ECMO center provides further treatment opportunities.

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Revisiting the core problem impeding the commercialization of silicon-based lithium-ion batteries

Ye Cheng, Chaozhen Zheng, Lihan Zhang, Shuwei Wang et autres

To meet the growing demand for high-energy-density lithium-ion batteries (LIBs), silicon (Si) anodes have gained attention as a promising material for next-generation anodes owing to their ultrahigh gravimetric capacity. Nevertheless, the Si anode faces significant challenges, particularly severe volume expansion during cycling, …

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Dissection of the cell communication interactions in lung adenocarcinoma identified a prognostic model with immunotherapy efficacy assessment and a potential therapeutic candidate gene ITGB1

Xing Jin, Zhengyang Hu, Jiacheng Yin, Guangyao Shan et autres

Background: The tumor microenvironment (TME) in lung adenocarcinoma (LUAD) influences tumor progression and immunosuppressive phenotypes through cell communication. We aimed to decipher cellular communication and molecular patterns in LUAD. Methods: We analyzed scRNA-seq data from LUAD patients in multiple cohorts, revealing complex …

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Clinically relevant variants detected in Chinese children with global developmental delay/intellectual disability: An exome-wide sequencing study

Yimeng Qiao, Nan Lv, Tongchuan Li, Ye Cheng et autres

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