Madoka Hokama

10149-CS-13 Clinical findings of central nervous system germ cell tumors with loss of endocrinal function

Joji Ishida, Yoshihiro Otani, Shuichiro Hirano, Yohei Inoue et autres

Abstract Introduction Central nervous system germ cell tumors originating in the neurohypophysis or hypothalamus present with various endocrine symptoms, delaying diagnosis up to several years in some cases. Therefore, early diagnosis and treatment are important. Subjects and Methods Retrospective review was performed …

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TMET-25. TNFR1 Knockdown Sensitizes Glioblastoma Cells to Cell Death

Yasuki Suruga, Yoshihiro Otani, Atsuhito Uneda, Naoya Kemmmotsu et autres

Abstract BACKGROUND Glioblastoma (GBM) is the brain tumor with poor prognosis, despite advances in surgery, radiation, and chemotherapy. Tumor necrosis factor (TNF) signaling, particularly through TNF receptor 1 (TNFR1), has been associated with inflammation and tumor biology in GBM. However, its precise …

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Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma

Shuichiro Hirano, Atsuhito Uneda, Yoshihiro Otani, Yasuki Suruga et autres

screening successfully identified candidate drugs for GSCs and DGCs. These results suggest that the dual targeting of GSCs and DGCs may help overcome intratumoral heterogeneity in glioblastoma.

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Identification of factors related to functional prognoses in craniopharyngiomas

Tsuyoshi Umeda, Yoshihiro Otani, Kentaro Fujii, Joji Ishida et autres

PURPOSE: Craniopharyngiomas are histologically benign tumors, but their proximity to vital neurovascular structures can significantly deteriorate functional prognoses and severely restrict patients' social interaction and activity. We retrospectively identified risk factors related to the functional prognoses in patients with craniopharyngioma treated at …

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Comparative analysis of intraoperative MRI and early postoperative MRI findings in glioma surgery patients

Yoshihiro Otani, Fumiyo Higaki, Kentaro Fujii, Joji Ishida et autres

OBJECTIVE: The extent of resection (EOR) is an important prognostic factor for both low- and high-grade gliomas. Intraoperative MRI (iMRI) has been used to increase the EOR in glioma surgery. While a recent study reported differences between iMRI and early postoperative MRI …

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TMIC-31. MOLECULAR PROGNOSTIC FACTORS OF THE PROGRESSION OF VESTIBULAR SCHWANNOMA AFTER PRIMARY TUMOR RESECTION

Ryo Mizuta, Keigo Makino, Yoshihiro Otai, Kentaro Fujii et autres

Abstract BACKGROUND Although vestibular schwannoma is a benign tumor, 10% of the tumor regrow after primary tumor resection. The factors associated with tumor progression from several reports remain controversial, and the role of the tumor microenvironment in vestibular schwannoma is still unclear. …

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NIMG-08. IMAGING FINDINGS AND PROGNOSTIC FACTORS IN DIFFUSE HEMISPHERIC GLIOMA, H3 G34-MUTANT

Yasuhito Kegoya, Yoshihiro Otani, Ryosuke Ikemachi, Ryo Omae et autres

Abstract INTRODUCTION Diffuse hemispheric glioma, H3 G34-mutant (DHGs), are a newly categorized tumor in pediatric-type diffuse high-grade gliomas in the 2021 World Health Organization classification, with a poor prognosis. DHGs has been reported to occur in less than 1% of all gliomas, …

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Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis

Ryoji Imoto, Yoshihiro Otani, Kentaro Fujii, Joji Ishida et autres

Tectal glioma (TG) is a rare lower grade glioma (LrGG) that occurs in the tectum, mainly affecting children. TG shares pathological similarities with pilocytic astrocytoma (PA), but recent genetic analyses have revealed distinct features, such as alterations in KRAS and BRAF. We …

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Efficiency of the novel quenching-probe PCR method to detect 23S rRNA mutations in children with Mycoplasma pneumoniae infection

Akira Nagita, Hirotada Muramatsu, Madoka Hokama, Masao Takami et autres

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Large-vessel vasculitis induced by granulocyte colony-stimulating factor administration after chemotherapy

Koichiro Yamamoto, Nayu Tamura, Kosuke Oka, Kou Hasegawa et autres

Granulocyte colony-stimulating factor (G-CSF) is a relatively new drug that is used for recovery of chemotherapy-associated neutropenia. It is known to cause bone pain, headache and fatigue as side-effects; however, large-vessel vasculitis is extremely rare and its relation with G-CSF remains unknown. …

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Critical Endothelial Regulation by LRP5 during Retinal Vascular Development

Wei Y. Huang, Qing Li, Mahmood Reza Amiry-Moghaddam, Madoka Hokama et autres

Vascular abnormalities in the eye are the leading cause of many forms of inherited and acquired human blindness. Loss-of-function mutations in the Wnt-binding co-receptor LRP5 leads to aberrant ocular vascularization and loss of vision in genetic disorders such as osteoporosis-pseudoglioma syndrome. The …

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[Intestinal permeability in Crohn's disease and effects of elemental dietary therapy].

Masaki Iwata, Hiroki Nakano, Yuichiro MATSUURA, Mitsuo Nagasaka et autres

Enteral intake of non-metabolic monosacharide and disaccharide, followed by measurement of the urinary excretion ratio of the two, is a method used to investigate intestinal permeability. L/R ratio (lactulose/1-rhamnose urinary excretion ratio) is considered an indicator of permeability of the small intestine. …

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