Ismael Henarejos-Castillo

Evaluation of Atrial Fibrillation Polygenic Risk Scores for the Prediction of Arrhythmia Recurrence after Atrial Fibrillation Ablation

Adrian Petzl, Paloma Jordà, Amélie Jeuken, Ismael Henarejos-Castillo et autres

ca (code pays fourni par la source)

Polygenic and Monogenic Contributions to Tachycardia-Associated Cardiomyopathy

Sina Safabakhsh, Paloma Jordà, Steffany Grondin, Ismael Henarejos-Castillo et autres

ca, us (code pays fourni par la source)

Are We Considering All the Potential Drug–Drug Interactions in Women’s Reproductive Health? A Predictive Model Approach

Pablo Garcia-Acero, Ismael Henarejos-Castillo, Francisco Jose Sanz, Patricia Sebastián-León et autres

Background: Drug–drug interactions (DDIs) may occur when two or more drugs are taken together, leading to undesired side effects or potential synergistic effects. Most clinical effects of drug combinations have not been assessed in clinical trials. Therefore, predicting DDIs can provide better …

es (code pays fourni par la source)

Whole-exome sequencing and Drosophila modelling reveal mutated genes and pathways contributing to human ovarian failure

Ismael Henarejos-Castillo, F. Sanz, Cristina Solana‐Manrique, Patricia Sebastian-Leon et autres

BACKGROUND: Ovarian failure (OF) is a multifactorial, complex disease presented by up to 1% of women under 40 years of age. Despite 90% of patients being diagnosed with idiopathic OF, the underlying molecular mechanisms remain unknown, making it difficult to personalize treatments …

es, gb (code pays fourni par la source)

Identification of novel drug-drug interactions: towards precision medicine in women’s reproductive health

Pablo Garcia-Acero, Ismael Henarejos-Castillo, Patricia Sebastian-Leon, Antonio Párraga-Leo et autres

ABSTRACT Drug-drug interactions (DDIs) may occur when two or more drugs are taken together, leading to undesired side effects or potential synergistic effects. Most clinical effects of drug combinations have not been assessed in clinical trials. Therefore, predicting DDIs can provide better …

es (code pays fourni par la source)

Predicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions

Ismael Henarejos-Castillo, Almudena Devesa-Peiró, Lucía de Miguel–Gómez, Patricia Sebastián-León et autres

COVID-19 exerts systemic effects that can compromise various organs and systems. Although retrospective and in silico studies and prospective preliminary analysis have assessed the possibility of direct infection of the endometrium, there is a lack of in-depth and prospective studies on the …

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Machine Learning-Based Approach Highlights the Use of a Genomic Variant Profile for Precision Medicine in Ovarian Failure

Ismael Henarejos-Castillo, Alejandro Alemán, Begoña Martinez-Montoro, Francisco Javier Gracia-Aznárez et autres

Ovarian failure (OF) is a common cause of infertility usually diagnosed as idiopathic, with genetic causes accounting for 10–25% of cases. Whole-exome sequencing (WES) may enable identifying contributing genes and variant profiles to stratify the population into subtypes of OF. This study …

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SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle

Ismael Henarejos-Castillo, Patricia Sebastián-León, Almudena Devesa-Peiró, António Pellicer et autres

es (code pays fourni par la source)