Antonio Párraga-Leo

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologies

Celeste Cohen, Antonio Párraga-Leo, Leticia Rodríguez-Montes, Christina E. Kim et autres

Abstract Single cell transcriptomics has transformed our knowledge of reproductive tissues, yet studies remain largely organ-specific and temporally limited, leaving an incomplete picture of how cell types are distributed across the reproductive system over a lifetime. Gynaecological conditions affect more than one …

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Epigenetic clock timing in the endometrium of women undergoing in vitro fertilization

Nataly del Aguila, Francisco José Sanz, Patricia Sebastian-Leon, Mónica Romeu et autres

Objective To evaluate endometrial epigenetic age acceleration (EEAA)—the difference between epigenetic and chronological age—in endometrial tissue from patients undergoing in vitro fertilization (IVF), using Horvath's DNA-methylation–based clock. Design Cross-sectional observational study with prospective, multicenter data collection. Subjects A total of 91 Caucasian …

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Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research

Jonathan L. Golob, Tomiko Oskotsky, Alice Tang, Alennie Roldan et autres

A Drug Repurposing Strategy for a New Cause of Endometrial Infertility: Unveiling Promising New Treatments

Antonio Párraga-Leo, Patricia Sebastián-León, Josefa María Sanchez-Reyes, F. Sanz et autres

STUDY QUESTION: Which mechanisms of action and candidate drugs can be used to treat endometrial failure caused by molecular alterations rather than endometrial timing? SUMMARY ANSWER: Genistein, pioglitazone, alprostadil, flunisolide, and tenoxicam emerged as potential therapies to treat two molecular causes of …

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Systems Pharmacology Model Predicts Zinc and Copper Can Be Repurposed as Endometriosis Therapies

Pablo Garcia-Acero, F. Sanz, Patricia Sebastián-León, Almudena Devesa-Peiró et autres

Abstract BACKGROUND Endometriosis is a complex and polygenic disease characterized by the growth of endometrial-like tissue outside the uterus. Associated conditions include pelvic pain and infertility among others. Current treatments of endometriosis are not effective in many patients and are prone of …

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Evaluating the feasibility of hyperspectral endometrial analysis as a less invasive technique for endometrial evaluation: a pilot study

Diana Marti-Garcia, Patricia Sebastian-Leon, Pilar Alamá, Laura Caracena et autres

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Stratifying IVF population endometria using a prognosis gradient independent of endometrial timing

Josefa María Sanchez-Reyes, Antonio Párraga-Leo, Patricia Sebastián-León, C. Vidal et autres

STUDY QUESTION: Can the disrupted window of implantation (WOI) be stratified according to transcriptomic patterns associated with reproductive success in IVF patients undergoing HRT? SUMMARY ANSWER: There are four transcriptomic patterns independent of endometrial timing associated with a gradient of reproductive prognosis …

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Are We Considering All the Potential Drug–Drug Interactions in Women’s Reproductive Health? A Predictive Model Approach

Pablo Garcia-Acero, Ismael Henarejos-Castillo, Francisco Jose Sanz, Patricia Sebastián-León et autres

Background: Drug–drug interactions (DDIs) may occur when two or more drugs are taken together, leading to undesired side effects or potential synergistic effects. Most clinical effects of drug combinations have not been assessed in clinical trials. Therefore, predicting DDIs can provide better …

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P-443 Intra biopsy analysis of the Endometrial Failure Risk (EFR) gene expression signature reveals an excellent concordance in the diagnosis overcoming tissue heterogeneity

A Martinez-Martinez, Patricia Sebastián-León, Antonio Párraga-Leo, C. Vidal et autres

Abstract Study question What is the impact of endometrial biopsy heterogeneity on the reproducibility of EFR gene expression signature diagnosis? Summary answer The EFR gene expression signature exhibits remarkable consistency between the gene expression of different portions from the same biopsy. What …

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Identification of novel drug-drug interactions: towards precision medicine in women’s reproductive health

Pablo Garcia-Acero, Ismael Henarejos-Castillo, Patricia Sebastian-Leon, Antonio Párraga-Leo et autres

ABSTRACT Drug-drug interactions (DDIs) may occur when two or more drugs are taken together, leading to undesired side effects or potential synergistic effects. Most clinical effects of drug combinations have not been assessed in clinical trials. Therefore, predicting DDIs can provide better …

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Stratifying IVF population endometria using a prognosis gradient independent of endometrial timing

Josefa María Sanchez-Reyes, Antonio Párraga-Leo, Patricia Sebastián-León, C. Vidal et autres

ABSTRACT Background Independent of endometrial timing, there are molecular causes of implantation failure that disrupt the endometrial transcriptome in the mid-secretory phase. However, the molecular mechanisms disrupting the window of implantation (WOI) remain poorly understood. The molecular heterogeneity of this endometrial disruption …

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VMAP: Vaginal Microbiome Atlas during Pregnancy

Antonio Párraga-Leo, Tomiko Oskotsky, Boris Oskotsky, Camilla Wibrand et autres

Objectives: To enable interactive visualization of the vaginal microbiome across the pregnancy and facilitate discovery of novel insights and generation of new hypotheses. Material and Methods: Vaginal Microbiome Atlas during Pregnancy (VMAP) was created with R shiny to generate visualizations of structured …

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