Darío I. Carrasco

Permethrin elicits chemoreceptive responses on different Anopheles gambiae sensory appendages

Sassan Simplice Kambou, Adeline Valente, Philip Agnew, Anna Cohuet et autres

ABSTRACT BACKGROUND Non-contact detection of pyrethroid insecticides by malaria mosquitoes has been unveiled and may contribute to the evolution of mosquito behavioral modifications against vector control tools. However, the mechanisms underlying this detection are not yet fully understood. It has been hypothesized …

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Emergent epileptiform activity in spinal sensory circuits drives ectopic bursting in afferent axons and sensory dysfunction after cord injury

Matthew Bryson, Heidi E. Kloefkorn, Shaquia Idlett-Ali, Darío I. Carrasco et autres

ABSTRACT: Spinal cord injury leads to hyperexcitability and dysfunction in spinal sensory processing. As hyperexcitable circuits can become epileptiform, we explored whether such activity emerges in a thoracic spinal cord injury (SCI) contusion model of neuropathic pain. Recordings from spinal sensory axons …

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Proportions of four distinct classes of sensory neurons are retained even when axon regeneration is enhanced following peripheral nerve injury

Samia Khan, Darío I. Carrasco, Robin H. Isaacson, ARTHUR WM. ENGLISH

Introduction: Recovery from peripheral nerve injuries is poor because axon regeneration is slow and inefficient. Experimental therapies that increase signaling of neuronal brain-derived neurotrophic factor (BDNF) through its TrkB receptor or through its downstream effectors enhance axon regeneration, increasing the number of …

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A Transverse Velocity Spectral Estimation Method for Ultrafast Ultrasound Doppler Imaging

Bowen Jing, Darío I. Carrasco, Nicholas AuYong, Brooks D. Lindsey

A novel transverse velocity spectral estimation method is proposed to estimate the velocity component in the direction transverse to the beam axis for ultrafast imaging. The transverse oscillation was introduced by filtering the envelope data after the axial oscillation was removed. The …

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Treatments with the specific δ‐secretase inhibitor, compound 11, promote the regeneration of motor and sensory axons after peripheral nerve injury

Robin H. Isaacson, Darío I. Carrasco, Hannah Holliday, Seong Su Kang et autres

Limited axon regeneration following peripheral nerve injury may be related to activation of the lysosomal protease, asparaginyl endopeptidase (AEP, δ-secretase) and its degradation of the microtubule associated protein, Tau. Activity of AEP was increased at the site of sciatic nerve transection and …

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Author response for "Treatments with the specific δ‐secretase inhibitor, compound 11, promote the regeneration of motor and sensory axons after peripheral nerve injury"

Robin H. Isaacson, Darío I. Carrasco, Hannah Holliday, Seong Su Kang et autres

Treatments with the specific δ-secretase inhibitor, compound 11, promote the regeneration of motor and sensory axons after peripheral nerve injury.

Robin H. Isaacson, Darío I. Carrasco, Hannah Holliday, Seong Jae Kang et autres

Limited axon regeneration following peripheral nerve injury may be related to activation of the lysosomal protease, asparaginyl endopeptidase (AEP, δ-secretase), and its degradation of the microtubule associated protein, Tau. Activity of AEP was increased at the site of sciatic nerve transection and …

us, cn (code pays fourni par la source)

Data from Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy

Stephen Nick Housley, Paul Nardelli, Darío I. Carrasco, Travis M. Rotterman et autres

Abstract For the constellation of neurologic disorders known as chemotherapy-induced peripheral neuropathy, mechanistic understanding and treatment remain deficient. Here, we present the first evidence that chronic sensory neuropathy depends on nonlinear interactions between cancer and chemotherapy. Global transcriptional profiling of dorsal root …

Movie S1 from Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy

Stephen Nick Housley, Paul Nardelli, Darío I. Carrasco, Travis M. Rotterman et autres

Uneven ladder walking of an ApcWT+control rat.

Figure Legends from Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy

Stephen Nick Housley, Paul Nardelli, Darío I. Carrasco, Travis M. Rotterman et autres

Supplemental Figure Legends

Figure S19 from Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy

Stephen Nick Housley, Paul Nardelli, Darío I. Carrasco, Travis M. Rotterman et autres

LD1 analysis of all neuronal parameters

Figure S18 from Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy

Stephen Nick Housley, Paul Nardelli, Darío I. Carrasco, Travis M. Rotterman et autres

Neuronal signaling responses to slow and fast naturalistic stimulus in ApcWT+control and ApcPirc/++OX neurons.