Accès ouvert
2026
other
OpenAlex
Valentina Poletto, Dmitry Lim, Silvia Dragoni, Adele Aronica et autres
Endothelial progenitor cells (EPCs) are mobilized from either bone marrow or arterial walls to restore blood perfusion to ischemic organs and establish the vascular network within growing tumors [1]. The Ca2+ machinery plays a key role in EPC activation and might serve …
Accès ouvert
2026
other
OpenAlex
Germano Guerra, Silvia Dragoni, Valentina Poletto, Mariapia Cinelli et autres
Endothelial progenitor cells (EPCs) are mobilized into circulation to replace damaged endothelial and recapitulate the vascular network of injured tissues (Moccia F et al., 2014). Intracellular Ca(2+) signals are key to EPC activation, but it is yet to be elucidated whether they …
Accès ouvert
2026
other
OpenAlex
Germano Guerra, Francesco Domenico Moccia, Franco Tanzi, Silvia Dragoni et autres
Endothelial progenitor cells (EPCs) traffic from the bone marrow to the site of tissue regeneration and sustain neo-vascularization after acute vascular injury and upon the angiogenic switch in solid tumors. Therefore, they represent a suitable tool for cell-based therapy in regenerative medicine …
Accès ouvert
2026
other
OpenAlex
Valentina Poletto, Marco Biggiogera, Elisa Bonetti, Matteo Giovanni Della Porta et autres
Endothelial progenitor cells (EPCs) may be released from bone marrow to sustain the angiogenic switch that promotes tumor growth and metastatization of several solid cancers (Moccia et al., 2014). It has long been thought that tumor endothelium represents a rather stable structure, …
Accès ouvert
2026
other
OpenAlex
Germano Guerra, Valentina Poletto, Marco Biggiogera, Silvia Dragoni et autres
Endothelial colony forming cells (ECFCs) are the only endothelial progenitor cells (EPCs) subtype belonging to the endothelial phenotype and capable of forming neovessels in vivo. We have recently shown that the intracellular Ca2+ machinery plays a key role in ECFC activation and …
Accès ouvert
2026
other
OpenAlex
Germano Guerra, Estella Zuccolo, Dmitry Lim, Vittorio Rosti et autres
Basal forebrain neurons increase cortical blood flow by releasing acetylcholine (Ach), which stimulates endothelial cells (ECs) to produce the vasodilating gasotransmitter, nitric oxide (NO). Surprisingly, the mechanism whereby Ach induces NO synthesis in brain microvascular ECs is unknown. An increase in intracellular …
Accès ouvert
2026
article
OpenAlex
Giovanni Barosi, Vittorio Rosti, Luca Malcovati, Robert Peter Gale
Not available.
it, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Rita Campanelli, Stefania Mantovani, Christian Ramirez, Toma Tebaldi et autres
Emergency myelopoiesis in cancer and chronic inflammation leads to the accumulation of myeloid-derived suppressor cells (MDSCs) which localize at tumor sites or areas of chronic inflammation, serving as suppressor cells. Besides reducing the cytotoxic functions of T/NK cells, these cells are major …
it, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Giovanni Barosi, Vittorio Rosti, R. D. Gale
This phenotype closely mirrors a subset of individuals we have previously described and proposed as a distinct clinical
it, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Giovanni Barosi, Annalisa De Silvestri, Robert Peter Gale, Vittorio Rosti
Median overall survival of people with primary myelofibrosis (PMF) varies significantly, ranging from approximately 14 years in pre-fibrotic PMF to around 7 years in overt PMF [ 1 ]. These figures underscore the critical importance of accurate survival prediction to guide timely …
it, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Giovanni Barosi, Vittorio Rosti, Rita Campanelli, Margherita Massa et autres
To improve our knowledge on the epidemiological, clinical and pathobiological profile of clonal megakaryocyte dysplasia with normal blood values (CMD-NBV), a BCR::ABL-negative myeloproliferative neoplasms clinical variant, we here report a series of 30 consecutive subjects with CMD-NBV. Sixteen subjects were men and …
it, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Valentina Biagioli, Alessandro Inzoli, Antonella Barone, Alessandra Iurlo et autres
PURPOSE: To identify predictors of self-care in patients with myeloproliferative neoplasms (MPN) and test the role of self-efficacy in mediating the relationship between patient health engagement and self-care. METHODS: A cross-sectional study was carried out in 9 haematology centres across Italy. A …
it, us
(code pays fourni par la source)