Festus Njuguna

The impact of malaria-induced neutrophil subset shift and a link to Burkitt lymphoma

Ronald Tonui, Titus Maina, Eddy O. Agwati, Cliff I. Oduor et autres

Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that remains a leading cause of childhood cancer mortality in sub-Saharan Africa. Although the epidemiological link between Plasmodium falciparum (Pf) malaria and BL has been established, our understanding of the underlying immunological mechanisms conducive …

Kenya, us (code pays fourni par la source)

Using flow cytometry for paediatric leukaemia diagnosis in Kenya: a protocol for mixed methods study

Tyler Severance, Teresa Lotodo, Enock Serem, Festus Njuguna et autres

INTRODUCTION: Each year, an estimated 1700 children should be diagnosed with cancer in western Kenya, with leukaemia making up nearly one-third of cases. However, far fewer are actually diagnosed, highlighting significant delays or errors in diagnosis. Flow cytometry, which the WHO considers …

us, Kenya (code pays fourni par la source)

Editorial: Innovations in supportive care in global pediatric oncology

C. Nathan Nessle, Ana Patricia Alcasabas, Miguela A. Caniza, Festus Njuguna et autres

Over 90% of children diagnosed with cancer live in low-and middle-income countries (LMICs) where the cure rate is under 30% compared to over 85% in high-income countries. 1,2 The health disparities contributing to the poor outcomes in LMICs are multifactorial and closely …

us, ph, jp, Kenya (code pays fourni par la source)

Prospective Cohort Study Testing Interventions to Reduce Diagnosis Delay and Treatment Abandonment of Children With Burkitt Lymphoma in Kenya

Sandra Langat, Festus Njuguna, Nicholas Kigen, Martha Kipngetich et autres

PURPOSE Low survival rates among children with Burkitt lymphoma (BL) in low- and middle-income countries (LMICs) are caused by multiple factors, including delays in diagnosis and treatment abandonment. These issues are often linked to the cost of diagnostic tests, treatment, and transportation. …

nl, Kenya, us (code pays fourni par la source)

Building a Comprehensive Sickle Cell Disease Program in Western Kenya: A Decade of Experience and Growth

Festus Njuguna, Carole Kilach, Cyrus Njuguna, Erick Ayaye et autres

Background: Globally, approximately 515,000 infants with Sickle Cell Disease (SCD) are born every year. Approximately 80% of these cases occur in Sub‑Saharan Africa (SSA) annually, including 14,000 newborns in Kenya. In SSA, 50%–80% of children will die before the age of 5 …

Kenya, us (code pays fourni par la source)

Massive Intra‐Abdominal Pseudotumor in a Patient With Hemophilia A Treated With Emicizumab: A Case Report

C. J. Kilach, Cyrus Njuguna, Festus Njuguna, C. M. Wanjiku et autres

Hemophilic pseudotumors, a rare complication of bleeding disorders, are more common in settings with limited access to clotting factor concentrates. Subcutaneous emicizumab, a relatively novel therapy for hemophilia A, was investigated for its ability to stabilize an inoperable pseudotumor in a patient …

Kenya, us (code pays fourni par la source)

Barriers to care for newly diagnosed children with cancer from Bungoma County after an awareness campaign: insights from parental interviews and registry data

Larissa Klootwijk, Lilian Apadet Osamong, Sally Kimaiyo, Terry A. Vik et autres

INTRODUCTION: Children in low- and middle-income countries face barriers to timely access to cancer care. Between January and June 2023, an awareness campaign in Bungoma County, Kenya, aimed to address this issue. This study describes sociodemographic and clinical characteristics of children diagnosed …

nl, Kenya, us (code pays fourni par la source)

Improving fever management of hospitalized children with cancer: barriers, facilitators, and proposed interventions from healthcare providers in Kenya

Lenah Nyamusi, Kenneth Busby, Sarah Kinja, Festus Njuguna et autres

Children with cancer in lower-middle-income countries (LMICs) are at increased risk of dying from infections. Prompt treatment of fever episodes improves outcomes, yet poorly described challenges impair management. This qualitative study explored healthcare provider perspectives on barriers to and facilitators of inpatient …

us (code pays fourni par la source)

Improving fever management of hospitalized children with cancer: barriers, facilitators, and proposed interventions from healthcare providers in Kenya

Everlyn Kisembe, C. Nathan Nessle, Julia C. Dettinger, Lenah Nyamusi et autres

Children with cancer in lower-middle-income countries (LMICs) are at increased risk of dying from infections. Prompt treatment of fever episodes improves outcomes, yet poorly described challenges impair management. This qualitative study explored healthcare provider perspectives on barriers to and facilitators of inpatient …

Kenya, us, nl (code pays fourni par la source)

Significant Impact of Treatment Abandonment on Survival of Children With “Common and Curable” GICC Index Cancers in Sub‐Saharan Africa—A Multicenter Prospective CANCaRe Africa Study

Mulugeta Ayalew Yimer, Diriba Fufa, Festus Njuguna, Cecilia Mdoka et autres

BACKGROUND: The World Health Organization Global Initiative for Childhood Cancer (GICC) targets a global survival rate of 60% for childhood cancer, focusing initially on six common, curable cancers. This study describes survival rates of five of these cancers in sub-Saharan Africa and …

Éthiopie, Kenya, Malawi, Cameroun, ca, Ghana, Ouganda (code pays fourni par la source)

Impact of a Childhood Cancer Awareness Program in Kenya: Sociodemographic Insights, Referral Trends, and Barriers to Care for Newly Diagnosed Children

Larissa Klootwijk, Lilian Apadet Osamong, Sally Kimaiyo, Terry A. Vik et autres

nl, Kenya, us, np (code pays fourni par la source)

Innovative Training to Improve Childhood Cancer Knowledge Among Primary Health Care Providers: Evaluating a Blended Learning Program in Kenya

Larissa Klootwijk, Lilian Apadet Osamong, Ibrahim El Salih, Rana Dandis et autres

PURPOSE Early detection and timely referral are vital to improving childhood cancer outcomes in low- and middle-income countries. However, training primary health care providers (HCPs) remains challenging because of limited time and resources. This study assesses the knowledge of primary health care …

nl, Kenya, us (code pays fourni par la source)