Christine Hinz

Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

Magdalena A. Czubala, Patricia Rodrigues, Natacha Ipseiz, Marcela Rosas et autres

Tissue-resident peritoneal macrophages (pMФ) programmed by GATA6 are essential players regulating immunity and tissue balance in the peritoneal cavity. How GATA6 regulates global lipid metabolism is currently unknown. Addressing this, in myeloid-restricted Gata6-deficient (Gata6-KOmye) mice, significant changes to the pMФ lipidome were …

ca, gb (code pays fourni par la source)

Reviewer #1 (Public review): Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

Magdalena A. Czubala, Patricia Rodrigues, Natacha Ipseiz, Marcela Rosas et autres

Tissue-resident peritoneal macrophages (pMФ) programmed by GATA6 are essential players regulating immunity and tissue balance in the peritoneal cavity. How GATA6 regulates global lipid metabolism is currently unknown. Addressing this, in myeloid-restricted Gata6-deficient (Gata6-KOmye) mice, significant changes to the pMФ lipidome were …

Reviewer #2 (Public review): Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

Magdalena A. Czubala, Patricia Rodrigues, Natacha Ipseiz, Marcela Rosas et autres

Tissue-resident peritoneal macrophages (pMФ) programmed by GATA6 are essential players regulating immunity and tissue balance in the peritoneal cavity. How GATA6 regulates global lipid metabolism is currently unknown. Addressing this, in myeloid-restricted Gata6-deficient (Gata6-KOmye) mice, significant changes to the pMФ lipidome were …

Reviewer #3 (Public review): Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

Magdalena A. Czubala, Patricia Rodrigues, Natacha Ipseiz, Marcela Rosas et autres

Tissue-resident peritoneal macrophages (pMФ) programmed by GATA6 are essential players regulating immunity and tissue balance in the peritoneal cavity. How GATA6 regulates global lipid metabolism is currently unknown. Addressing this, in myeloid-restricted Gata6-deficient (Gata6-KOmye) mice, significant changes to the pMФ lipidome were …

Author response: Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

Magdalena A. Czubala, Patricia Rodrigues, Natacha Ipseiz, Marcela Rosas et autres

Tissue-resident peritoneal macrophages (pMФ) programmed by GATA6 are essential players regulating immunity and tissue balance in the peritoneal cavity. How GATA6 regulates global lipid metabolism is currently unknown. Addressing this, in myeloid-restricted Gata6-deficient (Gata6-KOmye) mice, significant changes to the pMФ lipidome were …

Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

Magdalena A. Czubala, Patricia Rodrigues, Natacha Ipseiz, Marcela Rosas et autres

Tissue-resident peritoneal macrophages (pMФ) programmed by GATA6 are essential players regulating immunity and tissue balance in the peritoneal cavity. How GATA6 regulates global lipid metabolism is currently unknown. Addressing this, in myeloid-restricted Gata6-deficient (Gata6-KOmye) mice, significant changes to the pMФ lipidome were …

ca, gb (code pays fourni par la source)

Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

Magdalena A. Czubala, Patricia Rodrigues, Natacha Ipseiz, Marcela Rosas et autres

Abstract Tissue-resident peritoneal macrophages (pMФ) programmed by GATA6 are essential players regulating immunity and tissue balance in the peritoneal cavity. How GATA6 regulates global lipid metabolism is currently unknown. Addressing this, in myeloid-restricted Gata6 -deficient (G ata6 -KO mye ) mice, significant …

ca, gb (code pays fourni par la source)

Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry

Nils Helge Schebb, Nadja Kampschulte, Gerhard Hagn, Kathrin Plitzko et autres

Several oxylipins are potent lipid mediators that regulate diverse aspects of health and disease and whose quantitative analysis by liquid chromatography-mass spectrometry (LC-MS) presents substantial technical challenges. As members of the lipidomics community, we developed technical recommendations to ensure best practices when …

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Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting

Milton Pereira, J. Liang, Joy Edwards-Hicks, Allison M. Meadows et autres

Elevated interleukin (IL)-1β levels, NLRP3 inflammasome activity, and systemic inflammation are hallmarks of chronic metabolic inflammatory syndromes, but the mechanistic basis for this is unclear. Here, we show that levels of plasma IL-1β are lower in fasting compared to fed subjects, while …

gb, us, ch (code pays fourni par la source)

Assessment of Platelet Function by Automated Light Transmission Aggregometry

Mayukh K. Sarkar, Christine Hinz

jp (code pays fourni par la source)

Guilty by dissociation: Part A: Development of a rapid Ultra-High Performance Liquid Chromatography (UHPLC)-MS/MS methodology for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS)

Jennifer K. Field, Christine Hinz, Christopher M. Titman, Matthew C. Hulme et autres

gb (code pays fourni par la source)

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

Mariya Misheva, Konstantinos Kotzamanis, Luke C. Davies, Victoria J. Tyrrell et autres

Oxylipins are potent biological mediators requiring strict control, but how they are removed en masse during infection and inflammation is unknown. Here we show that lipopolysaccharide (LPS) dynamically enhances oxylipin removal via mitochondrial β-oxidation. Specifically, genetic or pharmacological targeting of carnitine palmitoyl …

gb, us, de, ca (code pays fourni par la source)