Narin Bak

Effect of in vitro synergy and additivity of vancomycin or daptomycin plus an antistaphylococcal β-lactam for methicillin-resistant Staphylococcus aureus bacteraemia on mortality: preplanned analysis from CAMERA2

J. Soo, Tze-Peng Lim, Jayden J.Y. Ho, Steven Y.C. Tong et autres

sg, au (code pays fourni par la source)

Association of Daily Body Temperature, White Blood Cell Count, and C-reactive Protein With Mortality and Persistent Bacteremia in Patients With Staphylococcus Aureus Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial

Sean Wei Xiang Ong, Nick Daneman, Joshua Saul Davis, Steven Y. C. Tong et autres

Abstract Introduction Classification of patients with Staphylococcus aureus bacteremia as complicated versus uncomplicated is based on a combination of clinical and microbiologic variables. Whether daily body temperature and common laboratory tests such as C-reactive protein (CRP) and white blood cell (WBC) can …

au, ca (code pays fourni par la source)

Genomic investigation and clinical correlates of the in vitro β-lactam: NaHCO 3 responsiveness phenotype among methicillin-resistant Staphylococcus aureus isolates from a randomized clinical trial

Neta Petersiel, Stefano G. Giulieri, Diane S. Daniel, Sook‐Ha Fan et autres

ABSTRACT NaHCO 3 responsiveness is a novel phenotype where some methicillin-resistant Staphylococcus aureus (MRSA) isolates exhibit significantly lower minimal inhibitory concentrations (MIC) to oxacillin and/or cefazolin in the presence of NaHCO 3 . NaHCO 3 responsiveness correlated with treatment response to β-lactams …

au, us (code pays fourni par la source)

Combination of Antistaphylococcal β-Lactam With Standard Therapy Compared to Standard Therapy Alone for the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia: A Post Hoc Analysis of the CAMERA2 Trial Using a Desirability of Outcome Ranking Approach

Neta Petersiel, Joshua Saul Davis, Niamh Meagher, David Jonathan Price et autres

Abstract Background Desirability of outcome ranking (DOOR) is an emerging approach to clinical trial outcome measurement using an ordinal scale to incorporate efficacy and safety endpoints. Methods We applied a previously validated DOOR endpoint to a cohort of CAMERA2 trial participants with …

au (code pays fourni par la source)

Longer-term Mortality and Kidney Outcomes of Participants in the Combination Antibiotics for Methicillin-Resistant Staphylococcus aureus (CAMERA2) Trial: A Post Hoc Analysis

Amy Legg, Matthew A. Roberts, Jane Davies, Alan Cass et autres

Abstract Background The Combination Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus (CAMERA2) trial ceased recruitment in July 2018, noting that a higher proportion of patients in the intervention arm (combination therapy) developed acute kidney injury (AKI) compared to the standard therapy (monotherapy) arm. …

au, il, sg, fr, us (code pays fourni par la source)

COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study

Victoria G. Hall, Beatrice Sim, Chhay Lim, Christopher M. Hocking et autres

Background: The global COVID-19 pandemic disproportionately affected certain populations and its management differed between countries. This national study describes characteristics and outcomes of COVID-19 in patients with cancer in Australia. Methods: We performed a multicentre cohort study of patients with cancer and …

au, cz (code pays fourni par la source)

Time-to-positivity in bloodstream infection for Candida species as a prognostic marker for mortality

Caitlin Keighley, Alun Lloyd Pope, Debbie Marriott, Sharon C.‐A. Chen et autres

Time-to-positivity (TTP) may assist in predicting the outcome of candidaemia. We analysed a candidaemia dataset collected prospectively in Australia over 1 year (2014-2015). TTP was defined as the period from blood culture sampling to the blood culture flagging positive. Of 415 candidaemia …

au (code pays fourni par la source)

Additional file 1 of Vancomycin-resistant Enterococcus faecium sequence type 796 - rapid international dissemination of a new epidemic clone

Andrew A. Mahony, Andrew H. Buultjens, Susan A. Ballard, Elizabeth A. Grabsch et autres

Table S1. A summary of the isolates with their epidemiological and meta-data. (XLSX 22 kb)

au, nz (code pays fourni par la source)

Suboptimal COVID ‐19 vaccine uptake among hospitalised patients: an opportunity to improve vulnerable, hard‐to‐reach population vaccine rates

Matthew Blake Roberts, Catherine Craun Ferguson, Erin M. McCartney, Kendra D. Selvanderan et autres

BACKGROUND: COVID-19 vaccination represents a key preventative part of the Australian public health approach to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Hospital inpatients are frequently high risk for severe COVID-19 and death. Anecdotes of high-risk inpatients being unvaccinated and …

au (code pays fourni par la source)

Risk factors for candidaemia: A prospective multi‐centre case‐control study

Caitlin Keighley, Alun Lloyd Pope, Deborah J. E. Marriott, Belinda Chapman et autres

OBJECTIVES: Candidaemia carries a mortality of up to 40% and may be related to increasing complexity of medical care. Here, we determined risk factors for the development of candidaemia. METHODS: We conducted a prospective, multi-centre, case-control study over 12 months. Cases were …

au (code pays fourni par la source)

Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study

Jiajun Liu, Steven Y. C. Tong, Joshua Saul Davis, Nathaniel J. Rhodes et autres

Abstract Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin …

us, au (code pays fourni par la source)

Lessons from practice Low attenuation lymphadenopathy on computed tomography leading to diagnosis of Whipple disease

Andrew S. Vanlint, Patricia Kaazan, Marco Kwok, Robert Venning Bryant et autres

us, au, bb (code pays fourni par la source)