Christina J. DeCoste

Host metadherin coordinates hepatic lipid metabolism and CD8+ T cell immunity to promote tumor progression

Yong Tang, Ziqing Chen, Hirak Sarkar, Yong Wei et autres

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Long-term safety of canakinumab in patients with systemic juvenile idiopathic arthritis: 5-year results from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry

Alis Burciu, Amita Bansal, Anne Dennos, Deepak Narayanswamy et autres

BACKGROUND: Systemic juvenile idiopathic arthritis (SJIA) is a severe form of juvenile idiopathic arthritis characterized by fever, rash, chronic arthritis, and systemic inflammation. The introduction of biologics has improved the treatment options for SJIA. Canakinumab selectively inhibits interleukin-1β and is approved for …

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Tumors hijack macrophages for iron supply to promote bone metastasis and anemia

Hirak Sarkar, Zhan Xu, Sereno Lopez-Darwin, Yongyue Wei et autres

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CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis

Eun-Mi Lee, Jason J Hong, Natalie Sauerwald, Yong Wei et autres

Tumor-initiating cells (TICs) share features and regulatory pathways with normal stem cells, yet how the stem cell niche contributes to tumorigenesis remains unclear. Here, we identify CXCR4+ macrophages as a niche population enriched in normal mammary ducts, where they promote the regenerative …

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Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia

Hirak Sarkar, Zhan Xu, Sereno Lopez-Darwin, Yong Wei et autres

Abstract Bone marrow is both a primary site for blood cell production and a fertile niche for metastatic cancer cell growth, notably in breast cancer. Although anemia is common among patients with bone metastasis, the mechanistic link between metastatic colonization and disrupted …

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Implementation study of the CARRA Uveitis Consensus Treatment Plans: feasibility for clinical practice and applicability for research

Margaret H. Chang, Fatima Barbar‐Smiley, Shoghik Akoghlanian, Joanne Drew et autres

BACKGROUND: Chronic anterior uveitis (CAU) carries a significant risk for eye complications and vision loss. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) introduced consensus treatment plans (CTPs) to standardize treatment for CAU and facilitate future comparative effectiveness studies. Two CTPs were …

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FISH-TAMB, a Fixation-Free mRNA Fluorescent Labeling Technique to Target Transcriptionally Active Members in Microbial Communities

Rachel L. Harris, Maggie C. Y. Lau, Esta van Heerden, Errol D. Cason et autres

Abstract Keystone species or ecological engineers are vital to the health of an ecosystem; however, often, their low abundance or biomass present challenges for their discovery, identification, visualization and selection. We report the development of fluorescent in situ hybridization of transcript-annealing molecular …

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FISH-TAMB, a fixation-free mRNA fluorescent labeling technique, to target transcriptionally active members in microbial community

Rachel L. Harris, Maggie C. Y. Lau, Esta van Heerdeen, Errol D. Cason et autres

us, cn, Afrique du Sud (code pays fourni par la source)

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis

Mark Esposito, Fang Cao, Katelyn C. Cook, Nana Park et autres

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Counting Chromosomes in Individual Bacteria to Quantify Their Impacts on Persistence

Allison M. Murawski, Christina J. DeCoste, Gary Laevsky, Mark P. Brynildsen

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Fluorescent in situ hybridization of transcript‐annealing molecular beacons (FISH‐TAMB) – an innovative method to tag active, low‐abundance prokaryotic cells

Maggie C. Y. Lau, Rachel L. Harris, Anjali Taneja, Christina J. DeCoste et autres

cn, us, Afrique du Sud (code pays fourni par la source)

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

Rumela Chakrabarti, Toni Celià-Terrassa, Sushil Kumar, Xiang Hang et autres

The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway ligand, is enriched in mammary gland stem cells (MaSCs) and mediates critical interactions with stromal macrophages in the …

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