Keyan Hu

Shared diagnostic biomarkers in metabolic syndrome and coronary artery disease identified by integrated bioinformatics and machine learning

Nuojin Wang, Keyan Hu, Shuting Zhang, Hongxing Zhao et autres

Background: Metabolic syndrome (MetS) comprises various complicated metabolic disorders. Coronary artery disease (CAD) is a major cardiovascular disease worldwide. These two diseases are the principal causes of morbidity and mortality in older adults. Previous studies have suggested a potential link between these …

MiR-221-3p facilitates cutaneous wound healing in diabetic mice

Yanlei Wang, Jie Pei, Yao Dai, Yujin Ma et autres

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Functional validation of a non-canonical HNF1B splice-site variant in MODY5

Xinran Gong, Liyuan Zhang, Qiaobo Ma, Yu Zhang et autres

Background Mutations in the HNF1B gene can cause developmental and functional abnormalities in multiple organs such as the pancreas, kidneys, and liver. The patient is a 19-year-old male with normal growth and development, presenting with a 9-year history of diabetes that remains …

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Metabolomics identifies chenodeoxycholic acid as a protective factor in diabetic foot ulcers

Ying Li, Ran Guo, Lu Lv, Tao Jiang et autres

Objective Diabetic foot ulcers (DFU) are a severe complication with high amputation and mortality rates, involving profound metabolic dysregulation. Current treatments lack interventions targeting the metabolic microenvironment. Chenodeoxycholic acid (CDCA) regulates glucose/lipid metabolism and inflammation, but its role in DFU remains unknown. …

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Potential application of mono-, dual-, and triple-target GLP-1 receptor agonists in improving the prognosis of patients with diabetic foot ulcers

Zhe Li, Xujing Wang, Yan He, Keyan Hu et autres

Diabetic foot ulcer (DFU), a severe chronic complication of diabetes mellitus, poses a major public health threat due to its high rates of disability, recurrence, and all-cause mortality. The mortality rate of DFU patients is closely related to cardiovascular events, indicating that …

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Understanding the correlation between benevolent childhood experiences, negative life events and mental health: The role of health risk behaviors

Li Zhu, Li Gong, Keyan Hu, Jenna Xinyi Niu et autres

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Predictors of sleep modifiable factors and the correlation with non-suicidal self-injury: the important role of problematic mobile phone use and mental health

Li Zhu, Keyan Hu, Qingqing Kang, Yijing Chen et autres

BACKGROUNDS: Non-suicidal self-injury (NSSI) has long affected people's lives and is an important and serious public health issue, especially among college students. This study aims to identify modifiable factors, including problematic mobile phone use (PMPU) and mental health (MH), etc. Only a …

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The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders

Qiu Zhang, Yanlei Wang, Qingqing Kang, Yijing Chen et autres

purpose of this study was to investigate the relationship between AGEs, TSH, metabolic metrics and DN, and to provide evidence for future intervention. METHOD: This study selected community health service centers which had signed medical alliance agreement with the First Affiliated Hospital …

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Association Among BMI, Self-Esteem, and Nonsuicidal Self-Injury in Young Adults to Understand the Influence of Socioenvironmental Factors: Longitudinal Study

Qiu Zhang, Ruixue Ying, Xuemeng Liu, Keyan Hu et autres

Background: Nonsuicidal self-injury (NSSI) is a major public health problem leading to psychological problems in adolescents and young adults, similar to disorders such as depression and anxiety. Objective: The aims of this study were to investigate (1) the interaction between BMI and …

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Interactive correlations between artificial light at night, health risk behaviors, and cardiovascular health among patients with diabetes: A cross‐sectional study

Yi Zhang, Keyan Hu, Ying Tang, Qing Feng et autres

BACKGROUND: Artificial light at night (ALAN) is a common phenomenon and contributes to the severe light pollution suffered by more than 80% of the world's population. This study aimed to evaluate the relationship between outdoor ALAN exposure and cardiovascular health (CVH) in …

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Association between negative life events through mental health and non-suicidal self-injury with young adults: evidence for sex moderate correlation

Yi Zhang, Li Gong, Qing Feng, Keyan Hu et autres

BACKGROUND: Non-suicidal self-injury (NSSI) has exhibited an increasing trend in recent years and is now globally recognized as a major public health problem among adolescents and young adults. Negative life events (NLEs) are positively associated with NSSI. We sought to explore (1) …

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MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Keyan Hu, Lei Liu, Songtao Tang, Xin Zhang et autres

Diabetic foot ulcer (DFU), a serious complication of diabetes, remains a clinical challenge. MicroRNAs affect inflammation and may have therapeutic value in DFU. Here, we find that an miR-221-3p mimic reduces the inflammatory response and increases skin wound healing rates in a …

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