Georg Stary

Generation of high-quality reference control panels of human induced pluripotent stem cell clones from fibroblasts

Ellen Mosca, Elisabeth Stein, Jiss John, Manuela Kinzer et autres

Well-characterized iPSC reference panels are critical for developmental and disease-modeling research. We generated eleven iPSC clones from fibroblasts collected from four healthy, unrelated donors (two female, two male) using non-integrating Sendai virus reprogramming. Each clone was extensively validated according to current best …

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Generation of high-quality reference control panels of human induced pluripotent stem cell clones from PBMCs

Elisabeth Stein, Ellen Mosca, Jiss John, Manuela Kinzer et autres

High-quality, standardized iPSC reference lines are crucial for disease modeling and regenerative medicine. We generated and extensively characterized thirteen iPSC clones from PBMCs of five healthy donors (three female, two male) using non-integrating Sendai virus. This resource is distinguished by its standardized …

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Histological aging signatures for monitoring tissue-specific aging and disease

Ernesto Abila, Iva Buljan, Yimin Zheng, Lisa Kleißl et autres

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types across 983 individuals …

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Cutaneous graft-versus-host disease: From acute reactions to chronic sequelae

Caroline Possanner, Maria Sanz-Codina, Florian Winkler, Luisa Thebault et autres

Graft-versus-host disease (GVHD) is a frequent immune-mediated complication following allogeneic hematopoietic stem cell transplantation (HSCT), caused by a fundamental function of the immune system – the ability to distinguish between self and non-self. As a multi-systemic disorder, GVHD is characterized by tissue …

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Prevalent glutamyl-endopeptidases in the commensal skin microbiome have itch-relevant activity

Jan-Philpp Wittlinger, Sophie Weninger, J Seneca Silva, Aldine Tu et autres

Abstract Atopic dermatitis (AD) is frequently accompanied by pruritus, which has predominantly been attributed to skin colonization by Staphylococcus aureus , particularly through cleavage of protease-activated receptor 1 (PAR1) by the glutamyl endopeptidase (GEP) V8 protease. Whether related GEPs from other skin-associated …

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Organ Involvement and Treatment Response across Cutaneous Sarcoidosis Subtypes

Antonia Schett, Anna Gabriel, Koray Taşçılar, Georg Schett et autres

Cutaneous sarcoidosis presents with diverse morphologies, yet comparative data on systemic involvement, disease course and treatment response across subtypes remain limited. We conducted a 2-centre cross-sectional study including patients with histologically confirmed sarcoidosis identified through ICD codes, stratified into patients with and …

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Virus-specific resident memory T cell networks sustain immunity in human oral mucosa

Florian Winkler, C.J. Fischer, Laura Marie Gail, Florian Deckert et autres

BACKGROUND: ) cells at pathogen entry sites. The oral cavity is a critical mucosal barrier frequently exposed to viral pathogens; however, the phenotypic characteristics and spatial organization of virus-specific T cells in the human oral mucosa remain poorly understood. OBJECTIVE: This study …

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Histological aging signatures for monitoring tissue-specific aging and disease

Ernesto Abila, Iva Buljan, Yi-Min Zheng, Lisa Kleißl et autres

tissue-clocks v1.0.0 Source code release accompanying the Nature Medicine manuscript: Histological aging signatures enable inference of tissue-specific disease associations from blood Contents Full analysis pipeline for GTEx histopathology aging clocks Revision analyses: foundation models, external cohort validation, ICC reproducibility, Bland-Altman calibration, GNN …

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Histological aging signatures for monitoring tissue-specific aging and disease

Ernesto Abila, Iva Buljan, Yi-Min Zheng, Lisa Kleißl et autres

tissue-clocks v1.0.0 Source code release accompanying the Nature Medicine manuscript: Histological aging signatures enable inference of tissue-specific disease associations from blood Contents Full analysis pipeline for GTEx histopathology aging clocks Revision analyses: foundation models, external cohort validation, ICC reproducibility, Bland-Altman calibration, GNN …

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INVIVO EVALUATION OF SPIDER SILK AND HYDROGEL MODIFIED COLLAGEN NERVE CONDUITS IN LONG-GAP PERIPHERAL NERVE INJURY

Lorenz Semmler, Andreas Langa, Stefanie WIlfinger, Sebastian Rihl et autres

PURPOSE: Autologous nerve grafting remains the clinical gold standard for reconstruction of critical peripheral nerve gaps but is limited by donor site morbidity and restricted tissue availability. Collagen-based nerve conduits represent an attractive alternative; however, their regenerative capacity across long nerve gaps …

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INVIVO EVALUATION OF SPIDER SILK AND HYDROGEL MODIFIED COLLAGEN NERVE CONDUITS IN LONG-GAP PERIPHERAL NERVE INJURY

Lorenz Semmler, Andreas Langa, Stefanie Wilfinger, Sebastian Rihl et autres

PURPOSE: Autologous nerve grafting remains the clinical gold standard for reconstruction of critical peripheral nerve gaps but is limited by donor site morbidity and restricted tissue availability. Collagen-based nerve conduits represent an attractive alternative; however, their regenerative capacity across long nerve gaps …

at (code pays fourni par la source)

INVIVO EVALUATION OF SPIDER SILK AND HYDROGEL MODIFIED COLLAGEN NERVE CONDUITS IN LONG-GAP PERIPHERAL NERVE INJURY

Lorenz Semmler, Andreas Langa, Stefanie WIlfinger, Sebastian Rihl et autres

PURPOSE: Autologous nerve grafting remains the clinical gold standard for reconstruction of critical peripheral nerve gaps but is limited by donor site morbidity and restricted tissue availability. Collagen-based nerve conduits represent an attractive alternative; however, their regenerative capacity across long nerve gaps …