Maria Sanz-Codina

Cutaneous graft-versus-host disease: From acute reactions to chronic sequelae

Caroline Possanner, Maria Sanz-Codina, Florian Winkler, Luisa Thebault et autres

Graft-versus-host disease (GVHD) is a frequent immune-mediated complication following allogeneic hematopoietic stem cell transplantation (HSCT), caused by a fundamental function of the immune system – the ability to distinguish between self and non-self. As a multi-systemic disorder, GVHD is characterized by tissue …

at (code pays fourni par la source)

Prostatic tissue distribution of gepotidacin in patients undergoing prostatectomy: an ex vivo microdialysis and pharmacokinetic modelling study

Valentin al Jalali, Vincent Aranzana-Climent, Anselm Jorda, Felix Bergmann et autres

Objectives The objective of the study was to explore the distribution of gepotidacin into prostate tissue by ex-vivo microdialysis (MD) following a single oral dose of gepotidacin. Methods We developed and validated an ex-vivo MD technique to quantify unbound gepotidacin concentrations in …

at, fr, us, fi, gb (code pays fourni par la source)

Pharmacokinetics of ampicillin, sulbactam and combined ampicillin/sulbactam in subcutis, muscle and plasma: A microdialysis trial in healthy volunteers

Anselm Jorda, Lena Pracher, Marlene Prager, Felix Bergmann et autres

Background This study aimed to investigate pharmacokinetics (PK)/pharmacodynamic (PD) target attainment, tissue and plasma PK, and PK interactions of ampicillin/sulbactam. Methods Thirty healthy volunteers received a single intravenous 30-minute infusion of ampicillin 2000mg (n=10), sulbactam 1000mg (n=10), or ampicillin 2000mg/sulbactam 1000mg (n=10). …

at, de (code pays fourni par la source)

Wenn die Haut zuerst warnt: TEN-like Präsentation einer akuten kutanen GvHD

Maria Sanz-Codina, Damian Kostner, Axel Schulenburg, Christina Schellenbacher et autres

Zusammenfassung Toxisch-epidermale Nekrolyse (TEN) und die kutane Graft-versus-Host-Erkrankung (GvHD) sind seltene, lebensbedrohliche kutane Reaktionen, die nach hämatopoetischer Stammzelltransplantation (HSZT) auftreten können. Aufgrund ähnlicher klinischer und histologischer Erscheinungsbilder ist die Abgrenzung in komplexe Fällen schwierig. Wir berichten über einen 65-jährigen Patienten mit myelodysplastischem …

at (code pays fourni par la source)

313 Daptomycin Plasma and Subcutaneous Pharmacokinetics in Critically Ill Patients: Implications for Target Attainment in Skin and Soft Tissue Infections

Maria Sanz-Codina

at (code pays fourni par la source)

Host Biomarkers and Antibiotic Tissue Penetration in Sepsis: Insights from Moxifloxacin

Maria Sanz-Codina, Hartmuth Nowak, Markus Zeitlinger

BACKGROUND AND OBJECTIVE: Sepsis-induced pathophysiological changes may lead to pharmacokinetic variability which alters antibiotic concentrations at the host infection site. This poses a challenge in clinical practice, as sufficient antibiotic concentrations in tissue are necessary to effectively eradicate bacterial pathogens. In this …

at, de (code pays fourni par la source)

Stability of cytokine, cellular and clinical response to the intravenous LPS challenge repeated after one year: a healthy volunteer trial

Anselm Jorda, Lena Pracher, Sabine Eberl, Alina Nussbaumer‐Pröll et autres

Abstract Whether the magnitude of individual cytokine, cellular, and clinical responses to the intravenous lipopolysaccharide (LPS) challenge is constant in individuals over extended time periods is unknown. Nine healthy volunteers received an intravenous LPS injection of 2 ng/kg bodyweight twice at intervals …

at (code pays fourni par la source)

Target-site cefiderocol pharmacokinetics in soft tissues of healthy volunteers

Maria Sanz-Codina, Wisse van Os, Anh Duc Pham, Anselm Jorda et autres

BACKGROUND: Cefiderocol may potentially be used to treat skin and soft tissue infections (SSTIs). However, the pharmacokinetics of cefiderocol in human soft tissues have not yet been determined. The objective of the present PK study was to investigate whether target-site concentrations of …

at, nl, de (code pays fourni par la source)

In vitro resistance development gives insights into molecular resistance mechanisms against cefiderocol

Richard Kriz, Kathrin Spettel, Alina Pichler, Katharina Schefberger et autres

Cefiderocol, a novel siderophore cephalosporin, demonstrates promising in vitro activity against multidrug-resistant Gram-negative bacteria, including carbapenemase-producing strains. Nonetheless, only a few reports are available regarding the acquisition of resistance in clinical settings, primarily due to its recent usage. This study aimed to …

at (code pays fourni par la source)

Pharmacokinetics of isavuconazole at different target sites in healthy volunteers after single and multiple intravenous infusions

Felix Bergmann, Michael Wölfl‐Duchek, Anselm Jorda, Valentin al Jalali et autres

BACKGROUND: Invasive aspergillosis is a severe fungal infection that affects multiple organ systems including the CNS and the lungs. Isavuconazole, a novel triazole antifungal agent, has demonstrated promising activity against Aspergillus spp. However, data on the penetration of isavuconazole into the CNS …

at (code pays fourni par la source)

Linezolid brain penetration in neurointensive care patients

Arthur Hosmann, Miriam M. Moser, Wisse van Os, Leon Gramms et autres

BACKGROUND: Linezolid exposure in critically ill patients is associated with high inter-individual variability, potentially resulting in subtherapeutic antibiotic exposure. Linezolid exhibits good penetration into the CSF, but its penetration into cerebral interstitial fluid (ISF) is unknown. OBJECTIVES: To determine linezolid penetration into …

at, de (code pays fourni par la source)

209 Biomarkers of subcutaneous tissue antibiotic penetration in sepsis

Maria Sanz-Codina, Hartmuth Nowak, Markus Zeitlinger

at, de (code pays fourni par la source)