Edlue M. Tabengwa

FCRL1 immunoregulation in B cell development and malignancy

Murali Krishna Mamidi, Jifeng Huang, Kazuhito Honjo, Ran Li et autres

Immunotherapeutic targeting of surface regulatory proteins and pharmacologic inhibition of critical signaling pathways has dramatically shifted our approach to the care of individuals with B cell malignancies. This evolution in therapy reflects the central role of the B cell receptor (BCR) signaling …

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Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies

Sarah Sterrett, Lucinda A. Hall, Edlue M. Tabengwa, Kazuhito Honjo et autres

Quantification of the anti-SARS-CoV-2 antibody response has proven to be a prominent diagnostic tool during the COVID-19 pandemic. Antibody measurements have aided in the determination of humoral protection following infection or vaccination and will likely be essential for predicting the prevalence of …

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Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency

Kazuhito Honjo, Ronnie M. Russell, Ran Li, Weimin Liu et autres

Convalescent plasma (CP) is widely used to treat COVID-19, but without formal evidence of efficacy. Here, we report the beneficial effects of CP in a severely ill COVID-19 patient with prolonged pneumonia and advanced chronic lymphocytic leukemia (CLL), who was unable to …

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Convalescent Plasma-Mediated Resolution of Covid-19 in Humoral Immunodeficiency

Kazuhito Honjo, Ronnie M. Russell, Ran Li, Weimin Liu et autres

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Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status

Lauren Kelly Shea, Kazuhito Honjo, David T. Redden, Edlue M. Tabengwa et autres

Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in Western countries and is characterized by a progressive accumulation of CD5 + monoclonal B cells in the blood and bone marrow. The clinical course in CLL is remarkably heterogeneous; the monoclonal population …

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Differential binding of the HIV-1 envelope to phosphatidylserine receptors

Linlin Gu, Brian Sims, Alexandre Krendelchtchikov, Edlue M. Tabengwa et autres

Prior work has shown that the HIV-1 envelope of the human immunodeficiency virus (HIV) interacts directly with T-cell immunoglobulin mucin (TIM) family proteins. Herein, we demonstrate that HIV-1 envelope glycoproteins from varying HIV-1 clades bind differentially to TIM proteins and functionally similar …

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L-4F Inhibits Lipopolysaccharide-Mediated Activation of Primary Human Neutrophils

Oleg F. Sharifov, Xin Xu, Amit Gaggar, Edlue M. Tabengwa et autres

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Emerging Roles for the FCRL Family Members in Lymphocyte Biology and Disease

Fanyuan Li, Woong-Jai Won, Eugene Becker, Juliet L. Easlick et autres

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Evidence that 2-aminoethoxydiphenyl borate provokes fibrillation in perfused rat hearts via voltage-independent calcium channels

Peipei Wang, Patrick K. Umeda, Oleg F. Sharifov, Brian Halloran et autres

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Pharmacological evidence for Orai channel activation as a source of cardiac abnormal automaticity

Paul E. Wolkowicz, Jian Yuan Huang, Patrick K. Umeda, Oleg F. Sharifov et autres

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Abstract 20885: A Novel Mechanism for Cardiac Abnormal Automaticity: Orai-Linked Calcium Signaling

Paul E. Wolkowicz, Jian Yuan Huang, Patrick K. Umeda, Edlue M. Tabengwa et autres

Objective: The plasma membrane Orai proteins permit cell calcium entry in response to calcium store depletion. We address whether the heart contains these voltage-independent calcium channels & whe...

Quercetin induced tissue-type plasminogen activator expression is mediated through Sp1 and p38 mitogen-activated protein kinase in human endothelial cells

Wensheng Pan, Min Jung Chang, François M. Booyse, H E Grenett et autres

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