Zae Young Ryoo

Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma

Yu Rim Cho, Ke Huang, Zhibin Liu, Hyeonjin Kim et autres

Background: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains one of the leading contributors to cancer-related mortality worldwide, primarily due to the disease's therapeutic resistance and marked tumor heterogeneity. Among the molecular mechanisms implicated in HCC …

kr, cn (code pays fourni par la source)

LIN28A‒let-7b axis drives the aggressive and proinflammatory phenotype of rheumatoid arthritis fibroblast-like synoviocytes

Hee Young Chae, Kyungrim Yi, Su‐Geun Lim, Ji Yeong Park et autres

BACKGROUND: Fibroblast-like synoviocytes (FLS) are central mediators of synovial inflammation and joint destruction in rheumatoid arthritis (RA). While tumor necrosis factor-α (TNFα) is known to activate FLS, the upstream regulators that connect inflammatory stimulation with sustained stromal pathogenicity remain poorly defined. The …

kr (code pays fourni par la source)

Down-regulation of HSPA9 reduces tyrosine hydroxylase-positive neurons in mouse substantia nigra and induces Parkinson’s disease-like motor impairments

Hyejin Hyung, Soyoung Jang, Siyong Kim, Ji‐Eun Bae et autres

Parkinson’s disease (PD) is a progressive neurological disorder characterized by the degeneration of midbrain dopaminergic neurons and disabling motor impairments. Heat shock protein family A member 9 (HSPA9) play a crucial role in neuronal homeostasis by regulating the import of various mitochondrial …

kr (code pays fourni par la source)

Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway

Zhibin Liu, Ke Huang, Hai Huang, Eun-Kyung Kim et autres

Esophageal squamous cell carcinoma (ESCC), one of the most frequent malignant tumors of the digestive system, is marked by a poor prognosis and high mortality rate. There is a critical need for effective therapeutic strategies with minimal side effects. Isoquercitrin (IQ) is …

kr, cn, us (code pays fourni par la source)

Effects of PM2.5 Metal Components Derived From Porcine Farm Exposure on Sperm Function in Mice

Chae Yeon Kim, Chae Rim Kim, Eungyung Kim, Kanghyun Park et autres

This study aimed to identify the effects of major metal components present in particulate matter (PM)2.5 on the reproductive system, sperm function, and embryo development. Through intratracheal instillation, male mice were exposed to various concentrations of metal components, including calcium oxide (Ca), …

kr, cn (code pays fourni par la source)

HSD17B4 deficiency causes dysregulation of primary cilia and is alleviated by acetyl-CoA

Ji-Eun Bae, Soyoung Jang, Joon Bum Kim, Na Yeon Park et autres

Primary cilia are dynamic sensory organelles orchestrating key signaling pathways, and disruption of primary ciliogenesis is implicated in a spectrum of genetic disorders. The peroxisomal bifunctional enzyme HSD17B4 is pivotal for peroxisomal β-oxidation and acetyl-CoA synthesis, and its deficiency profoundly impairs peroxisomal …

kr, be (code pays fourni par la source)

PRPF4 Knockdown Suppresses Glioblastoma Progressionviathe p38 MAPK and ERK Signaling Pathways

Wansoo Kim, Hee-Yeon Kim, Seoung-Woo Lee, Dae‐Hwan Kim et autres

BACKGROUND/AIM: Pre-mRNA processing factor 4 (PRPF4), a core protein of U4/U6 small nuclear ribonucleoproteins (snRNPs), is crucial for maintaining their structure by interacting with PRPF3 and Cyclophilin H. Beyond its role in splicing, PRPF4 has been implicated in cell survival, apoptosis, and …

kr (code pays fourni par la source)

Exploratory investigation of the correlation between microplastics and breast cancer: Polystyrene-derived microplastics promote cell proliferation via estrogenic endocrine disruption

Seoung-Woo Lee, Hee-Yeon Kim, Soyoung Jang, Wan-Soo Kim et autres

kr (code pays fourni par la source)

Mitochondrial LETMD1 sensitizes the central nervous system to ferroptosis and multiple sclerosis-like neuroinflammation

Zae Young Ryoo, Jiwon Ko

Gossypetin Alleviates DSS-induced Colitis by Regulating COX2 and ROS-JNK Signaling

Hyeonjin Kim, Eungyung Kim, Lei Ma, C.-W. Kim et autres

BACKGROUND: Inflammatory Bowel Disease (IBD) represents a chronic and recurrent inflammatory condition affecting the gastrointestinal tract, with a rising global incidence. Current treatment approaches include surgery and drugs. However, surgeries are invasive procedures, while drug treatments often present with various side effects. …

kr, cn (code pays fourni par la source)

hMAGEA2 as a potential diagnostic and therapeutic target for melanoma progression and metastasis

Jun Koo Yi, Chae Yeon Kim, Hyeonjin Kim, Eun-Kyung Kim et autres

The incidence of melanoma, a highly aggressive skin cancer, continues to increase worldwide, particularly among populations with lighter skin tones. The diagnostic challenge of melanoma lies in the absence of a distinctive clinical presentation, as its characteristics vary based on anatomical location, …

kr, tw, cn (code pays fourni par la source)

Effects of the major metal components in urban Asian PM2.5 on lung inflammation and abnormal electrolyte levels: an in vivo study based on review data

Eungyung Kim, Ke Huang, Junkoo Yi, Lei Ma et autres

Fine particulate matter (PM) 2.5 contains metals, ions, and carbon compounds, varying dynamically due to environmental factors. This study identified five major metals (Ca, Fe, Al, Zn and Pb) in urban PM2.5 via meta-analysis and evaluated their hazardous effects on health. Mice …

us, kr, cn (code pays fourni par la source)