Ning Yang

Mitochondrial Function Is Required to Preserve Viability of Stem Cells From the Apical Papilla Following Porphyromonas endodontalis Infection

Junpeng Li, Xincheng Wang, Si Yu, AN-CONG WANG et autres

AIMS: To investigate the effects of Porphyromonas endodontalis on the viability of stem cells from the apical papilla (SCAP) and to explore the role of mitochondrial function in supporting SCAP survival. METHODOLOGY: SCAP were isolated from immature third molars, and P. endodontalis …

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CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation

Jing Wu, Shan Zhu, Guoxia Zang, Helei Wang et autres

Background The tolerization of plasmacytoid dendritic cells (pDCs) within the tumor microenvironment facilitates immune evasion, thereby significantly limiting the efficacy of cancer immunotherapy. Metabolic regulators are crucial in determining immune cell fate. However, the specific metabolic modifications influencing tumor-associated pDCs (TA-pDCs) are …

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Hypoxia-responsive Exatecan prodrug liposomes co-delivered with IR808 for synergistic chemo–photodynamic therapy of breast cancer

Li Wang, Chunyun Xu, Yuan Liang, Ning Yang et autres

To overcome the poor solubility, rapid clearance, and systemic toxicity of Exatecan, we developed a tumor-activated liposomal delivery system co-encapsulating a hypoxia-cleavable Exatecan-squalene prodrug (EXA PRO) and the photosensitizer IR808. The nanocarrier integrates photodynamic therapy-induced hypoxia with bioreductive drug activation, enabling spatiotemporally …

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Age at disease onset and risk of chronic kidney disease in patients with heterozygous disease-causing variants in COL4A3 and COL4A4

Ningning Hu, Lei Sun, Xuantong Dai, Ziyi Zhao et autres

ABSTRACT Background A key goal in managing patients with heterozygous disease-causing COL4A3 and COL4A4 (COL4A3/4) variants, affecting individuals spanning a broad age range, is to slow the development of chronic kidney disease (CKD). Whether age of onset is associated with the risk …

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Cascade-responsive nanoplatform for synergistic cancer therapy via ROS amplification and hypoxia targeting

Chunyun Xu, Yanfang Ding, Jingjing Qi, Peng Chu et autres

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Alleviating abnormal stress on compressed cranial sutures: a potential mechanism for treating and preventing deformational plagiocephaly

Xin Ye, Jianfeng Huang, Yuanqi Liu, Qianyi Sun et autres

Abnormal stress in cranial sutures is strongly related to deformational plagiocephaly (DP) and is responsible for morphological changes in the skull, facial asymmetry, and abnormal facial tension. To evaluate the effect of biomechanical therapy on cranial sutures of DP we performed in …

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Allelopathic inhibitory of thymol on Arabidopsis thaliana primary root growth is mediated by ABA signaling pathway

Liai Ma, Kai Yin, Wenhui Zhu, Yuanbo Wang et autres

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Identification of Mitochondrial-related Characteristic Biomarkers inOsteosarcoma using Bioinformatics and Machine Learning

Jingyi Hou, Yu Zhang, Ning Yang, Bin Chen et autres

Background/Aims: Osteosarcoma (OS), a malignant tumor originating in bone or cartilage, primarily affects children and adolescents. Notably, substantial alterations in mitochondrial energy metabolism have been observed in OS; however, the specific contribution of mitochondrial- related genes (MRGs) to OS pathogenesis and prognosis …

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Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways

Yu Zhang, Hailong Lun, Naiqiang Zhu, Ning Yang et autres

Introduction: Osteosarcoma (OS), a prevalent metastatic cancer among young individuals, is associated with a grim prognosis. Long non-coding RNAs (lncRNAs), including C1QTNF1-AS1, are pivotal regulators of cancer cell proliferation and motility. As an oncogene, C1QTNF1-AS1 is implicated in various tumor types, such …

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Research on Construction Method of Path Angle Signal in MAGIC CARPET

Xiulin Zhang, Ning Yang, Hao Yun

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Research on chemical constituent differences in wild and cultivated Arnebia euchroma by combining UPLC-QTOF-MS with chemometrics

Rongrong Huang, Dianxing Wu, Rui Wu, Ning Yang et autres

In this study, UPLC-QTOF-MS was used to analyze the wild and cultivated Arnebia euchroma and the chemical constituent differences were determined by chemometric analysis including PCA, HCA, and OPLS-DA.

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The RNA helicase DHX35 functions as a co-sensor for RIG-I-mediated innate immunity

Yuan Qiao, Shan Zhu, Ning Yang, Shan–Shan Zou et autres

RNA helicases are involved in the innate immune response against pathogens, including bacteria and viruses; however, their mechanism in the human airway epithelial cells is still not fully understood. Here, we demonstrated that DEAH (Asp-Glu-Ala-His) box polypeptide 35 (DHX35), a member of …

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